Tag: MTHFR signs

Why Is a Toxicologist Making Claims About Vaccines and Autism?

It will never end, will it?

Both toxicologist and research should be in quote marks…

Vaccines are very clearly not associated with autism, but that doesn’t seem to keep us from getting new anti-vaccine heroes popping up now and then with new theories from their “research.”

Is it different this time?

Unlike most of the other anti-vaccine experts who are practicing way out of their field of expertise when they talk about vaccines, Ashley Everly is a toxicologist, so is actually an expert on vaccines, right?

“Most toxicologists begin by working at the bench, conducting experiments on in vitro and animal models. Over time, as they gain experience, they may move up to supervise others. While a master’s degree is sufficient for applied research positions, a Ph.D. degree with postdoctoral experience is required for the highest levels.”

Toxicology Overview

Ashley Everly does not have a master’s degree and has not published any research about vaccines. Her opinions are not those of a toxicologist, but of a mother who thinks that her child was injured by vaccines.

Her Facebook copypasta post, while posted as a toxicologist, should remind you of just one very important fact. The great majority of working toxicologists do not share her opinions about vaccines.

“Vaccines are among the most efficacious and cost-effective prevention tools… Parents of children with non-medical exemptions to immunization requirements have been documented to have perceptions of lower susceptibility to and severity of vaccine preventable diseases and perceptions of lower safety and efficacy of vaccines compared to parents of vaccinated children. Moreover, compared to parents of vaccinated children, vaccine hesitant parents had less trust in the government and the health care system.”

Scientific Liaison Coalition (SLC) Epidemiology of Vaccine Refusal webinar

What is the Scientific Liaison Coalition (SLC)?

It is a group of eight toxicology organizations that “increase awareness of toxicology and related sciences on human health,” including the:

  • American Academy of Clinical Toxicology (AACT)
  • American College of Toxicology (ACT)
  • Environmental Mutagenesis and Genomics Society (EMGS)
  • Safety Pharmacology Society (SPS)
  • Society for Risk Analysis (SRA)
  • Society of Toxicologic Pathology (STP)
  • Society of Toxicology (SOT)
  • Teratology Society (Teratology)
  • Union of Toxicology (IUTOX)

And not surprisingly, they teach folks that vaccines are safe, effective, and necessary.

Some of these folks are also the ones doing research on new vaccines.

But, of course, they do a lot more.

The Society of Toxicology wants everyone to know that they are working to help reduce our exposure to potential environmental sources of methylmercury.

“Toxicologists have played a major role in identifying the health risks associated with exposure to methylmercury.”

Society of Toxicology on Mercury : A Long-Appreciated Hazard

What don’t they scare folks about? Thimerosal and ethymercury in vaccines!

“Recent research has confirmed that the ethylmercury component found in Thimerosal is less hazardous than methylmercury. These are different compounds and should not be considered as equivalent neurotoxins. Experimental conditions can be created that result in neurological cell dysfunction. However, current literature supports the contention that childhood vaccinations do not deliver a sufficient dose to produce these neurological injuries.

American College of Medical Toxicology on the IOM Report on Thimerosal and Autism

Neither does the American College of Medical Toxicology.

Maybe that’s why Ashley Everly and other anti-vaccine folks have moved on to MTHFR, glyphosate, aborted fetal cell DNA, and aluminum

More on Toxicologists and Vaccine Safety

Is a Crooked Face a Sign of a Vaccine Injury?

Have you heard of the Crooked theory?

Is something really wrong with these Hollywood stars?
Does Zach Braff really have a crooked face?

If you haven’t, when you get done learning about it, the name is going to seem very ironic…

“Why do babies have lopsided smiles? Why are so many people’s eyes misaligned? What started as a simple search to understand this phenomenon turned into a two-year quest that uncovered hidden links between our crooked faces and some of the most puzzling diseases of our time.

From autism to Alzheimer’s and from chronic fatigue syndrome to Crohn’s disease, Crooked methodically goes through the most recent scientific research and connects the dots from the outbreak of metallic medicine in 1800s England to the eruption of neurological and autoimmune disorders so many are suffering from today.

If the theories put forth in this book are true, the convergence of metals, microbes and medicine that started two hundred years ago may have set humanity on a path of suffering that could make the deadliest epidemics in history pale in comparison. Thankfully, for the millions who are afflicted, who may have found nothing to explain the cause of their suffering — these same theories could also illuminate the path to healing and recovery.”

Forrest Maready on Crooked: Man-Made Disease Explained

Spoiler Alert – The “theories” put forth in his book are not true.

Are you crooked?

Forrest Maready might get asked that a lot these days for actually trying to sell a self-published book pushing the idea that he knows what causes everything “from autism to Alzheimer’s and from chronic fatigue syndrome to Crohn’s disease.”

Of course, he thinks that it is vaccines and aluminum.

“And that’s what makes this even worse. Not only is the theory completely false, it’s not even original!.”

Were We Crooked?

It isn’t.

This “theory” of “his” has been well debunked, ironically, by Maready himself!

Doesn't it look like many of these football players from 1899 had crooked faces?
Doesn’t it look like many of these football players from 1899 had crooked faces?

As others have pointed out, Forrest Maready debunked his own book when he posted old photographs of football players, claiming it proved that vaccines caused chronic traumatic encephalopathy.

Not only did many of the football players from the late 18th and early 19th century who played without helmets go on to develop chronic traumatic encephalopathy, if they didn’t die on the field, as you can see, many also had crooked faces!

Crooked faces, brain damage because they didn't wear helmets, and death from now vaccine preventable diseases - life was tough in the old days.
Crooked faces, brain damage because they didn’t wear helmets, and death from now vaccine preventable diseases – life was tough in the old days.

As early as the 1920s, after first being noticed in boxers, it was quickly discovered that CTE could also occur in football players. And again, many of the folks in these pics have crooked faces!

“All people have asymmetric faces. When one looks closely, these differences become more apparent.”

AAP on Children with Facial Asymmetry

It is hopefully obvious that the crooked face theory is all about cherry picking and confirmation bias. And that some folks think that everything and anything is a vaccine injury.

That this appears to be a credible theory by anti-vaccine folks says a lot about the modern anti-vaccine movement and why some folks don’t vaccinate their kids.

Don’t believe it.

Vaccines are safe and necessary and won’t make your child’s face look crooked.

More on the Crooked Face Theory

 

What Are the Signs of MTHFR Mutations?

Are you scared to vaccinate and protect your baby because you think she has signs of  MTHFR mutations?

What Are the Signs of MTHFR Mutations?

For some reason, some parents get concerned about MTHFR if their baby has:

  • a stork bite on the back of her neck (nevus simplex or salmon patch) – get it? that’s where the stork carriers the baby to you
  • a stork bite on the eyelids or forehead, although many people call it an angel’s kiss in these locations
  • a sacral dimple
  • a tongue-tie
  • any facial dimples
  • a strawberry hemangioma
  • a prominent blue vein on the bridge of her nose – called a sugar bug, because practitioners of traditional Chinese medicine think that it is linked to a sensitivity to sugar

And they somehow think that this a reason to delay or skip their child’s vaccines.

It isn’t.

Not surprisingly, none of the websites who list so-called signs of MTHFR mutations provide any evidence for why they are considered to be signs.

What Are the Real Signs of MTHFR Mutations?

If you are worried about MTHFR mutations, you have likely been warned that they cause a lot of different problems.

In reality, it is only known that MTHFR mutations can cause homocystinuria, a rare disorder of methionine metabolism. So you might expect those who have this mutation to have signs and symptoms of homecystinuria, including long limbs, chest deformities, and scoliosis, similar to Marfan syndrome.

Fortunately, many states now include testing for homecystinuria on their newborn screen.

Where Did the Other MTHFR Indicators Come From?

Some people also think that some common MHTFR polymorphisms, or gene variants, may be weakly associated with cardiovascular disease, migraines, anacephaly, spina bifida, and cleft lip and palate.

But this doesn’t mean that MHTFR mutations caused the child to have spina bifida or cleft lip and palate.

“In general, the following genotypes currently appear unlikely to be of clinical significance: “thermolabile” variant c.665C→T heterozygote, c.1286A→C homozygote, or (c.665C→T); (c.1286A→C) compound heterozygote.”

Hickey et al. on ACMG Practice Guideline: lack of evidence for MTHFR polymorphism testing

These polymorphisms are very common and you are going to find them when you look for them.

More and more studies are now finding that they are not associated with any diseases or extra risk of disease. And any risk for neural tube defects in pregnancy can be eliminated by taking folate supplements, which is now recommended for all pregnant women anyway.

But you now should be able to see where their list of bogus signs of MTHFR mutations came from. If spina bifida is supposed to be associated with MTHFR polymorphisms, then why not sacral dimples? And if cleft lip and palate is supposed to be associated with MTHFR polymorphisms, then why not tongue-tie?

Neither a stork bite nor tongue-tie is a sign of a MTHFR mutation. Photo by Vincent Iannelli, MD
Neither a stork bite nor tongue-tie is a sign of MTHFR mutations. Photo by Vincent Iannelli, MD

What about stork bites, hemangiomas, facial dimples, and the blue vein?

These are some of the most common things that pediatricians point out to parents during their first few appointments. New parents especially what to be reassured that all of these things, which can be very obvious, are eventually going to go away. And fortunately, they typically do – without treatment, although some hemangiomas do require treatment.

In fact, it is estimated that 30 to 50% of newborns have a stork bite. These dilated blood vessels typically go away without treatment. How many people have MHTFR polymorhisms? Yup, 30 to 50%. And no, that doesn’t mean that MHTFR polymorhisms cause stork bites.

Again, since MHTFR polymorhisms are common variants (not mutations that cause disease), you are going to find them associated with many other common conditions.

“Midline lumbosacral skin lesions (e.g., lipomas, dimples, dermal sinuses, tails, hemangiomas, hypertrichosis) are cutaneous markers of spinal dysraphism. A comprehensive review of 200 patients with spinal dysraphism found that 102 had a cutaneous sign. However, many children without spinal dysraphism also have these skin findings.”

McLaughlin et al. on Newborn Skin: Part II. Birthmarks

It is also very possible that folks are misunderstanding a recommendation about warnings for risks of occult spinal dysraphism. This occurs when there is incomplete fusion of the midline elements of the spine, but they are covered by skin, so unlike spina bifida, they are hard to detect. So we look for things like hemangiomas, hypertrichosis (hairy patches), nevus simplex (stork bite), and dimples, etc., as a sign that something might be wrong underneath the skin.

In general, if you have two or more of these skin lesions, a child’s risk for occult spinal dysraphism would be considered high, but, and this is important, the location of the skin lesions is what we look for. They would be over the midline lumbosacral area (the lower back). So an hemangioma on your child’s arm or chest wouldn’t be a risk. Neither would a stork bite on the nape of a baby’s neck or an angel kiss on their forehead.

But now you see the assumed link to MTHFR!

‘They’ think  that MTHFR mutations cause spina bifida, so they made the jump to all of these possible signs of occult spinal dysraphism being associated with MTHFR polymorpisms too, even when they aren’t actually signs of occult spinal dysraphism unless they are located on your baby’s lower back.

“MTHFR gene mutations can cause absolutely no symptoms at all. They can also cause severe irreversible health conditions such as Down’s syndrome. Research is still pending on which medical conditions are caused by, or at least partially attributed to, the MTHFR gene mutations. From the partial list I recently went through on Medline, these are the current symptoms, syndromes and medical conditions relating to the MTHFR gene mutations:”

Ben Lynch on MTHFR Mutations and the Conditions They Cause

A lot of what folks think they know about MTHFR mutations comes from Ben Lynch, who has a doctorate in Naturopathic Medicine (ND), recommends that folks get genetic testing, and then tells them all of the things that are wrong with them when the tests come back.

“Many of your health issues spring from a combination of overworked and underworked genes. These issues can often be resolved by supporting your genes—but you don’t know that.”

Ben Lynch on My Mission: Reach Your Genetic Potential

And even smarter mission would be to skip the genetic testing, especially if it includes MTHFR testing, and get your family vaccinated and protected.

What to Know About Signs of MTHFR Mutations

There are no signs of MTHFR mutations that you should be looking for that would indicate you should skip or delay any of your child’s vaccines.

More on Signs of MTHFR Mutations