Tag: Vaccine Preventable Diseases

Hedda Get Bedda Doll and Other Measles Stories

Hedda Get Bedda originally came with a hospital bed.
The Hedda Get Bedda doll originally came with a hospital bed.

In the early 1960s, the American Character Doll Company produced a series of Whimsie dolls, including:

  • Annie the Astronut
  • Fanny the Flapper
  • Hilda the Hillbilly
  • Lena the Cleaner (baseball)
  • Samson the Strongman
  • Simon the Degree
  • Wheeler the Dealer (casino dealer)
  • Zero the Hero

Hardly politically correct for our times, the stereotyped dolls do provide a look at the history of their time.

One other doll, Hedda Get Bedda, is especially helpful in that sense.

Made in 1961, this Whimsie doll could change her face, letting you know how she was feeling when you turned the knob on her head. She could go from having a sleeping face, to a sick face (perhaps having chicken pox or measles), to a happy face (once you made her better).

Does the fact that she also came with a hospital bed mean anything?

Just like some anti-vaccine folks like to think that the simple fact that they made a doll that had measles or chicken pox could possibly mean that they looked at them as mild diseases, you could just as easily say that including the hospital bed means ‘they’ understand they were life-threatening diseases that could put land you in the hospital.

We are talking about the pre-vaccine era after all, and in 1961, and when the Hedda Get Bedda doll came out, there were about 503,282 cases of measles in the United States and 432 measles deaths.

Like the Brady Bunch measles episode, the Hedda Get Bedda doll is sometimes used to push the myth that vaccine-preventable diseases aren’t that serious, helping folks justify their decisions to intentionally skip or delay vaccines and leaving their kids unprotected.

“…for those trained in pediatrics in the 1970s, Hib (Haemophilus influenzae type b) was a horror.”

Walter Orenstein, MD

For example, if you believed that measles, chicken pox, or Hib were mild diseases, then you might feel better about not getting your child the MMR, chicken pox, or Hib vaccines.

Sure, many people get measles and do get better without any complications. On their way to getting better though, even they have high, hard to control fever for 5 to 7 days, with coughing and extreme irritability.

But while most get better, we shouldn’t forget that some people don’t survive measles without complications. Natural immunity sometimes comes with a price, from vision problems and permanent hearing loss to brain damage.

And tragically, some people don’t get to survive measles.

Get Educated. Get Vaccinated.

For More Information and Measles Stories

Mumps Outbreaks

Pre-Vaccine Era Mumps Outbreaks

In the pre-vaccine era, mumps was a common childhood infection that could cause orchitis, meningitis, pancreatitis, deafness, and even death.

There were about 212,000 cases a year in the early 1960s, before the first mumps vaccine was licensed in 1968.

Post-Vaccine Era Mumps Outbreaks

Tips to prevent getting sick with the mumps.
A large Ohio mumps outbreak prompted an education campaign to help protect everyone from getting sick.

As with other vaccine-preventable diseases, there was a big drop in cases of mumps once the mumps vaccine was introduced.

In 1968, there were just over 152,000 cases and 25 deaths  and just ten years later, in 1978, that was down to 16,817 cases and 3 deaths.

Once the recommendation for the second dose of MMR came in 1990, it looked like mumps was on it’s way out.

We went from 5,292 cases and one death that year, to just 906 cases and no deaths in 1995. When measles hit its low point of 37 cases in 2004, there were just 258 cases of mumps.

That wasn’t the end for mumps though, as we had some up and down years, including big outbreaks in:

  • 2006 – 6,584 cases among Midwest college students and one death
  • 2008 – only 454 cases, but one death
  • 2009 – 1,991 cases and two deaths
  • 2010 – 2,612 cases mostly among Orthodox Jewish communities and two deaths
  • 2011 – 370 cases
  • 2012 – 229 cases
  • 2013 – 584 cases
  • 2014 – 1,223 cases involving a large outbreak in Ohio and in the NHL
  • 2015 – 1,057 cases mostly among university students in Iowa and Illinois

Could this all be because of waning immunity?

2016 Mumps Outbreaks

So far in 2016, the CDC reports that there have been:

  • at least 4,619 cases of mumps
  • cases have been reported in all states except Delaware, Louisiana, Vermont, and Wyoming
  • seven states, AK, IA, IN, IL, MA, NY, and OK with more than 100 cases in 2016

The most recent, ongoing outbreaks are in:

  • Arkansas (at least 2,159 cases) – which may be fueled by a large community of Marshall Islanders living in close quarters, with low levels of vaccinations among adults in the community
  • Oklahoma (at least 324 cases)
  • Washington (93 cases)
  • Long Beach, New York (45 cases), and at State University of New York (SUNY) at New Paltz in New York (13 cases)
  • Harvard University (4 cases)
  • University of Missouri (31 cases)
  • Tufts University (9 cases)
  • Texas – with most of the cases in North Texas, including a large outbreak in Johnson County (72 cases) and two other outbreaks linked to four different cheerleading competitions.

At SUNY New Paltz, most of the cases were among the swim team. In addition, 20 unvaccinated students were sent home from school under quarantine until December 3.

In Arkansas, 42 workplaces, 39 schools in six school districts, six colleges and two private schools in Benton, Carroll, Conway, Faulkner, Madison, Pulaski, and Washington counties are seeing most of the cases. A quarantine is in effect, with unvaccinated children being kept out of school for 26 days from the date of exposure or for the duration of the outbreak, whichever is longer.

Many of these outbreaks occur despite many of the cases having had two doses of the MMR vaccine. A third dose is sometimes recommended during these outbreaks.

That doesn’t mean that the MMR vaccine doesn’t work. After all, just compare today’s rates of mumps, even if they are a little higher than we would like, to pre-vaccine levels…

Getting two doses of the MMR vaccine is still the best way to avoid mumps.

There is no general recommendations to get extra shots though.

Keep in mind that the MMR vaccine isn’t just for kids. Adults who didn’t have mumps when they were kids (or who were born before 1957, when most kids got mumps), should make sure they are vaccinated (at least one dose) and protected too.

For More Information on Mumps Outbreaks:

References on Mumps Outbreaks:
CDC. Reported Cases and Deaths from Vaccine Preventable Diseases, United States, 1950-2013.

Updated on December 24, 2016

US Presidents and Vaccines

You would think that getting kids vaccinated and protected against vaccine-preventable diseases would be a non-partisan issue, but it unfortunately isn’t always the case.

donald-trump

Even before Donald Trump brought up false claims that vaccines cause autism, we have seen what can happen when funding for vaccines dropped. Federal support for vaccines dropped while Reagan was in office and we quickly saw outbreaks of vaccine-preventable diseases, including many deaths.

Fortunately, most American Presidents have strongly supported vaccines.

There is no longer any reason why American children should suffer from polio, diphtheria, whooping cough, or tetanus. … I am asking the American people to join in a nationwide vaccination program to stamp out these four diseases.

JFK in 1962

  • George Washington – had smallpox and later mandated that every soldier in the Continental Army had to be inoculated against smallpox
  • John Adams – was innoculated against smallpox (before Jenner‘s vaccine was available), as were his wife and children
  • Thomas Jefferson – conducted his own smallpox vaccine trials
  • James Madison – signed the Vaccine Act of 1813 – An Act to encourage Vaccination.
  • James K Polk – died of cholera, a now vaccine-preventable disease, three months after his term ended
  • Zachary Taylor – died of cholera while still in office
  • Abraham Lincoln – developed smallpox while he was in office
  • Franklin D Roosevelt – had polio and founded the National Foundation for Infantile Paralysis, which was later renamed the March of Dimes, and helped fund Jonas Salk‘s research on the first polio vaccine
  • Harry S Truman – had diphtheria as a child, which may have left him with vision problems, and was vaccinated against smallpox
  • Dwight D Eisenhower – signed the Polio Vaccination Assistance Act in 1955, which gave $30 million in federal grants to states to cover the costs of planning and conducting polio vaccination programs, including purchasing polio vaccine
  • John F Kennedy – signed the Vaccination Assistance Act in 1962 (Section 317 of the Public Health Service Act), which started as a three year program to help get kids vaccinated against polio, diphtheria, tetanus, and pertussis, but it has been continuously reauthorized ever since
  • Lyndon B Johnson – established a legacy of US leadership in global immunization by funding the CDC Smallpox Eradication program in 1965 (smallpox wasn’t eradicated until 1980)
  • Richard Nixon – observed that scientists who helped develop the polio vaccine with Jonas Salk “deserve far greater respect and support by the people whom they serve than they now receive.”
  • Gerald Ford – instituted a swine flu vaccination program for an outbreak that never appeared
  • Jimmy Carter – his National Childhood Immunization Initiative in 1977 reached its goal of immunizing 90% of children
  • Ronald Reagan – signed the National Childhood Vaccine Injury Act (NCVIA) of 1986, which created VAERS and the NVICP, while federal support for vaccine programs reached a low point in his years in office, as rates of children living in poverty and without health insurance increased
  • George HW Bush – his immunization action plan in 1991 once again raised immunization rates following three years of measles outbreaks
  • Bill Clinton – his Childhood Immunization Initiative in 1993 which included signing the Vaccines for Children (VFC) Act, provided free vaccines to many children
  • George W Bush – announced a major smallpox vaccination program in 2002, but very few healthcare workers actually volunteered to get vaccinated
  • Barack Obama – declared the 2009 H1N1 swine flu outbreak a national emergency, Obamacare requires health insurance plans to pay for vaccines without co-pays, made the Ebola outbreak a national security priority, and helped keep funding for Zika vaccine research going

What can we expect our next President to do about vaccines and vaccination rates?

For More Information on US Presidents and Vaccines:

Save

Pediatricians as Vaccine Pushers

We often here that pediatricians are vaccine pushers, at least from anti-vaccine folks…

If that is the case though, how come pediatricians don’t routinely push any of the following vaccines on kids:

  1. Adenovirus vaccine – only given to enlisted soldiers during basic training
  2. Anthrax vaccine – high risk people only
  3. BCG vaccine vaccine – high risk people only
  4. Cholera vaccine – recently approved in the United States as a travel vaccine
  5. Hepatitis E – not available in the United States
  6. Japanese encephalitis vaccine – a travel vaccine
  7. Meningococcal C vaccine (MenC) – not available in the United States
  8. Meningococcal B vaccine (MenB) –  has a “permissive” recommendation in that parents are told they can get it if they want their kids to avoid MenB infections, but it is not required yet.
  9. MenHibrix – a combination between Hib and Meningococcal Groups C and Y, but it is only given to high risk kids
  10. Plague vaccine – discontinued
  11. Rabies vaccine – high risk people only
  12. Shingles vaccine – seniors only
  13. Smallpox vaccine – high risk people only
  14. Tick-borne encephalitis – not available in the United States
  15. Typhoid fever vaccine – a travel vaccine
  16. Typhus vaccine – discontinued
  17. Yellow fever vaccine – a travel vaccine
The oral adenovirus vaccine is approved to prevent adenovirus infections in military populations.
The oral adenovirus vaccine is approved to prevent adenovirus infections in military populations.

Sure, it would be hard to push a vaccine that has been discontinued or not even available in the United States, but if your goal was to aggressively push vaccines, how hard would it be to get Big Pharma to start making them available?

That would more than double the number of vaccines that kids would have to get.

Those Times “Vaccine Pushers” Said No To Vaccines

And how come some of the biggest vaccine advocates have been against plans for mass immunizations if they are vaccine pushers?

In addition to Dr. Albert Sabin advising against President Gerald Ford’s plans for universal vaccination against swine flu in 1976, Dr. Paul Offit missed the chance to push the small pox vaccine on us in 2002. He instead advised for a different plan:

Here’s another way to do it. We can make the vaccine. Make sure we understand who’s going to get it, who’s going to be giving it. Then wait, wait for there to be one case of documented smallpox somewhere on the face of this earth and then we can move into vaccinating people, large numbers of people.

Dr. Paul Offit

Dr. Offit, who is routinely called a shameless vaccine pusher by anti-vaccine websites, was the sole member of a CDC vaccine advisory committee to vote against President George Bush’s 2002 plan to vaccinate about 500,000 health care workers against smallpox. He feared that the risks might outweigh the benefits.

For More Information on Vaccine Pushers

Save

This Year’s Flu Season

Flu activity is increasing across the United States.
Flu activity is increasing across the United States.

Breaking News: Widespread flu activity in 46 states and 29 pediatric flu deaths so far this flu season. (see below)

While flu season typically peaks in February, it is very important to understand that there are few things that are typical about the flu.

Since 1982, while we have been twice as likely to see a flu activity peak in February than other winter months, we have been just as likely to get that peak in December, January, or March. That makes it important to get your flu vaccine as soon as you can.

You really never know if it is going to be an early, average, or late flu season.

Flu Facts

While there will likely be some surprises this flu season – there always are – there are some things that you can unfortunately count on.

Among these flu facts include that:

  • there have been 1,482 pediatric flu deaths since the 2003-04 flu season, including 89 flu deaths last year
  • about 113 kids die of the flu each year – most of them unvaccinated
  • antiviral flu medicines, such as Tamiflu, while recommended to treat high-risk people, including kids under 2 to 5 years of age, have very modest benefits at best (they don’t do all that much, are expensive, don’t taste good, and can have side effects, etc.)
  • a flu vaccine is the best way to decrease your child’s chances of getting the flu

And even in a mild flu season, a lot of kids get sick with the flu.

This Year’s Flu Season

When does flu season start?

In general, flu season starts when you begin to see people around you with signs and symptoms of the flu, including fever, cough, sore throat, runny or stuffy nose, muscle or body aches, headaches, and fatigue, etc.

To be more accurate, you can also look at reports for flu activity in your area, especially the weekly reports from the CDC.

As of late January, the CDC is reporting that “flu activity continues to increase and is widespread in most of the United States.”

The CDC has also recently reported that:

  • this year’s flu vaccine reduces “the risk for influenza-associated medical visits by approximately half”
  • influenza A (H3N2) viruses, a component of this year’s flu vaccine, are predominating so far this flu season, which could be a sign of a severe flu season. In general, “H3N2-predominant seasons have been associated with more severe illness and higher mortality, especially in older people and young children…”
  • Is it a match? – “…antigenic and/or genetic characterization shows that the majority of the tested viruses remain similar to the recommended components of the 2016-2017 Northern Hemisphere vaccines.”
  • 46 states (up from 43), including Alabama, Alaska, Arizona, Arkansas, California, Connecticut, Delaware, Florida, Georgia, Idaho, Illinois, Indiana, Iowa, Kansas, Kentucky, Louisiana, Maine, Maryland, Massachusetts, Michigan, Minnesota, Mississippi, Missouri, Montana, Nebraska, Nevada, New Hampshire, New Jersey, New Mexico, New York, North Carolina, North Dakota, Ohio, Oklahoma, Pennsylvania, Rhode Island, South Carolina, South Dakota, Tennessee, Texas, Vermont, Virginia, Washington, West Virginia, Wisconsin, and Wyoming, are now reporting widespread flu activity (the highest level)
  • only 4 states, including Colorado, Hawaii, Oregon, and Utah, are still reporting regional flu activity
  • no states are still reporting local flu activity
  • no states are still reporting sporadic flu activity
  • there have been 29 pediatric deaths this flu season, including reports of 9 new deaths this week

Have you and your family gotten been vaccinated and protected against the flu yet?

“Anyone who has not gotten vaccinated yet this season should get vaccinated now.”

CDC Influenza Situation Update

If not, this is still a good time to get a flu vaccine.

Recent Flu Seasons

Are H3N2 predominant flu seasons really worse than others?

  • 2003-04 flu season – 152 pediatric flu deaths (H3N2-predominant)
  • 2004-05 flu season – 47 pediatric flu deaths
  • 2005-06 flu season – 46 pediatric flu deaths
  • 2006-07 flu season – 77 pediatric flu deaths
  • 2007-08 flu season – 88 pediatric flu deaths (H3N2-predominant)
  • 2008-09 flu season – 137 pediatric flu deaths
  • 2009-10 flu season – 289 pediatric flu deaths (swine flu pandemic)
  • 2010-11 flu season – 123 pediatric flu deaths
  • 2011-12 flu season – 37 pediatric flu deaths
  • 2012-13 flu season – 171 pediatric flu deaths (H3N2-predominant)
  • 2013-14 flu season – 111 pediatric flu deaths
  • 2014-15 flu season – 148 pediatric flu deaths (H3N2-predominant)
  • 2015-16 flu season – 89 pediatric flu deaths

In addition to high levels of pediatric flu deaths, the CDC reports that the four flu seasons that were H3N2-predominant in recent years were “the four seasons with the highest flu-associated mortality levels in the past decade.”

For More Information on the 2016-17 Flu Season

Updated February 19, 2017

Save

Save

Save

Save

Discontinued Vaccines

tripedia
The Tripedia DTaP vaccine was discontinued in 2013.

Most people know that the RotaShield rotavirus vaccine was discontinued in 1999 because it was found to be linked to intussusception.

It took eight years for a new rotavirus vaccine to be licensed.

Lymerix, a Lyme disease vaccine was discontinued in 2002. Unfortunately, we still don’t have a new replacement Lyme disease vaccine.

Vaccines That Have Been Discontinued

More commonly, a vaccine gets discontinued with little notice, as there are other options to keep kids vaccinated and protected.

Other vaccines that are no longer made, include:

  • Cervarix – an HPV vaccine that was discontinued in the US in 2016
  • Comvax –  a Hib/Hepatitis B combination – discontinued in 2014
  • Tetanus toxoid – discontinued 2013
  • Tripedia – a DTaP vaccine – discontinued 2011
  • TriHIBit – a DTaP/Hib combination
  • JE-VAX – discontinued 2005
  • Attenuvax – measles vaccine
  • Mumpsvax – mumps vaccine
  • Meruvax II – rubella vaccine
  • M-R-Vax – measles and rubella combo
  • M-M-Vax – measles and mumps combo
  • Biavax II – rubella and mumps combo
  • Heptavax-B – the original hepatitis B vaccine
  • HIB-Vax – the original Hib vaccine
  • Plague vaccine
  • Poliovax
  • Dryvax – smallpox vaccine
  • Measles-Smallpox combination vaccine
  • Diptussis – a diphtheria/pertussis combination (1949-55)
  • Quadrigen – a DTP/Polio combination (1959-68)
  • Streptococcus vaccine (1952-88)
  • Serobacterin – a pertussis vaccine (1945-54)
  • Rocky mountain spotted fever vaccine (1942-78)
  • Typhus vaccine (1941-79)
  • smallpox vaccine (1917-1976)

Most of these vaccines were discontinued because they simply became obsolete.

Orig. Title: SPvac806.8a
A smallpox vaccination kit included the diluent, a vial of Dryvax smallpox vaccine, and a bifurcated needle.

The Hib-Vax and Heptavax-B vaccines, for example, both use older technology, so these vaccines were discontinued when newer Hib and hepatitis B vaccines were introduced.

And some vaccines are discontinued  or are phased out when they get an update:

  • MMR -> MMR-II (1978)
  • Prevnar 7 -> Prevnar 13 (2010)
  • Gardasil -> Gardasil 9 (2014)

Still other vaccines, like Tripedia and TriHIBit, seemed to get discontinued as a business decision. Through mergers, Sanofi Pasteur, Ltd. ended up with two DTaP vaccines. They had their own Daptacel, but also had Tripedia, a vaccine they acquired from Pasteur Merieux. They ended up discontinuing Tripedia.

Merck also stopped making Comvax not because of “any  product safety or manufacturing issues,” but rather “as part of its ongoing effort to focus company resources on opportunities that provide the greatest value for customers, patients, and public health…”

Cervarix was discontinued because of low market demand. The competing HPV vaccine, Gardasil, had the much larger market share.

Vaccine Manufacturers and Discontinued Vaccines

And of course, some vaccine manufacturers simply stopped making vaccines.

The Texas Department of Health Resources once had a license to make vaccines, including DTP, diphtheria, DT, pertussis, tetanus, Td, and typhoid vaccines since 1950. They completely exited the vaccine market in 1979.

In the 1970s and 80s, dozens of vaccines were discontinued as Miles Inc., Eli Lilly, Parke Davis, and other companies stopped making vaccines.

While that is often downplayed these days, it is important to realize that we used to have much more competition among vaccine manufacturers. For example, in the early 1970s, the DTP vaccine was made by at least 11 different companies! We now have just two that make DTaP. And in many other cases, like for Prevnar, MMR-II, polio, and the chicken pox vaccine, there is just one manufacturer.

For More Information on Discontinued Vaccines:

Save

Vaccines In Development

Many of us have heard the news that there are “300 new vaccines in the pipeline.”

Of course, no one really believes that means scientists are out there developing vaccines against 300 separate diseases or that it will mean that kids will some day get 300 more vaccines.

So what does it mean?

Surprisingly, it doesn’t even mean 300 new vaccines in the pipeline anymore. The latest, 2016 update of the Medicines in Development for Vaccines report from the Pharmaceutical Research and Manufacturers of America now states that there are “More Than 250 Vaccines in Development Pipeline.”

To understand what that means, you have to take a look at the vaccines being developed, which include:

  • 124 for infectious diseases
  • 105 for cancers
  • thirteen for allergies
  • eight for neurological disorders
  • seven for other conditions

And even of the 124 vaccines in development or testing for infectious diseases:

  • 36 are to prevent or treat HIV
  • 25 are to prevent influenza, including new nasal flu vaccines
  • 8 are for RSV
  • 8 are for Ebola

So when they talk about “300 vaccines in the pipeline,” remember that even when you consider that only 124 of them are for infectious diseases, of those, 77 are for just 4 different infectious diseases.

The other 47 vaccines in various stages of development include vaccines for CMV, tuberculosis, dengue, Zika, GBS, West Nile virus, Staph, herpes, hepatitis C, E. coli, pseudomonas, malaria, C. diff infections, Shigella, norovirus, anthrax, smallpox, and ricin.

Some others are for infections that you have likely never heard of, including viral hemorrhagic fever, Ross River virus infections, and Venezuelan equine encephalitis.

And unfortunately, only 17 of these infectious disease vaccines are in stage III trials, which means that very, very few are close to seeing the inside of a pediatrician’s office.

Potential New Vaccines

Which vaccines have the greatest potential to be protecting our kids soon?

Based on which vaccines have completed phase III trials and have been submitted for registration to the FDA, the one likely candidate seems to be:

  • Dengvaxia – a dengue fever vaccine developed by Sanofi Pasteur which has already been approved in Brazil, Mexico, the Philippines, El Salvador and Costa Rica and is on a Fast Tract schedule in the United States

Other vaccines in late development phases include:

  • Shingrix – a new shingles vaccine
  • an MMR vaccine from GSK (already available in other countries)
  • Men Quad TT – a “second generation” meningococcal vaccine

And we may see the combination, pentavalent MenABCW-135Y meningococcal vaccine by 2021.

So much for 300 new vaccines…

For More Information on New Vaccines: