Tag: VAERS

ACIP June 2019 Update

The Advisory Committee on Immunization Practices (ACIP) holds three meetings each year at the Centers for Disease Control and Prevention (CDC) in Atlanta, Georgia to review scientific data and vote on vaccine recommendations.

Topics at the ACIP June 2019 meeting, held on June 26 and 27, included:

  • 9vHPV Immunogenicity and Safety Trial in Mid-Adult Females
  • Overview of Health Economic Models for HPV Vaccination of Mid-Adults
  • HPV Vaccines Evidence to Recommendations (EtR) Framework
  • HPV Vaccines Work Group Considerations and Proposed Policy Options
  • Considerations for PCV13 use among adults 65 years or older and summary of the Evidence to Recommendations (EtR) Framework Proposed policy options
  • Combination Vaccines – Summary and Relevant Evidence to Recommendation Information
  • Update: Safety Monitoring and Surveillance for Recombinant Zoster Vaccine (RZV)
  • Herpes Zoster Work Group Summary
  • Pertussis Vaccines EtR Framework, Work Group Considerations and Proposed Policy Options
  • Rabies Vaccine
  • 2018-19 U.S. Influenza Activity
  • 2018-19 Influenza Vaccine Effectiveness
  • 2018-19 Influenza Vaccine Safety
  • Influenza Vaccine Proposed Recommendations for 2019-20
  • Proposed Recommendations for Use of Hepatitis A
  • Dengue Epidemiology in the U.S.
  • Dengvaxia Phase III Clinical Trials and Long Term Follow Up
  • Dengue Vaccine Work Group Considerations and Next Steps

If you haven’t been watching the meeting, the slides, videos, and minutes will be available later.

ACIP June 2019 Meeting Votes

And ACIP members voted on a number of issues, including:

Passed.
Passed.
This changes the 2014 ACIP recommendation to give PCV13 to all adults 65 years or older.
A series of votes on DTaP, Hib, IPV, and hepB got Vaxelis, the newly FDA approved hexavalent vaccine, added to the VFC program.

Coming up tomorrow will be votes on flu, hepatitis A, and meningococcal B vaccines.

More on the ACIP June 2019 Meeting

Anaphylaxis After Vaccines

Anaphylaxis after vaccines is a well known side effect, but just how common is it?

Anaphylaxis After Vaccines

Since it is listed as a possible reaction to nearly all vaccines and it can be life-threatening, anaphylaxis must be fairly common, right?

“Vaccine providers should be familiar with identifying immediate-type allergic reactions, including anaphylaxis, and be competent in treating these events at the time of vaccine administration. Providers should also have a plan in place to contact emergency medical services immediately in the event of a severe acute vaccine reaction.”

Preventing and Managing Adverse Reactions

After all, pediatricians even get warned to have a plan in place and to be prepared to treat children just in case they develop anaphylaxis after getting their vaccines.

Your pediatrician will likely have an EpiPen in the office in case your child has an anaplylactic reaction after his vaccines.
Epi Is Readily Available to Treat Most Kids with Anaphylaxis After Vaccines

Still, most probably have never had to.

“Any medication can cause a severe allergic reaction. Such reactions to a vaccine are estimated at about 1 in a million doses, and would happen within a few minutes to a few hours after the vaccination.”

Possible Side-effects from Vaccines

And that’s because anaphylaxis after vaccines is very rare.

Anaphylaxis After Vaccines is Rarely Fatal

And suprisingly, it is even more rare for these cases to be fatal!

“All 30 patients with anaphylaxis survived (9 reports specified anaphylaxis, and we classified another 21 as probable cases, based on compatible clinical features, including respiratory and skin symptoms within 4 hours after vaccination). In half of 22 detailed reports, symptoms developed within 15 minutes after vaccination.”

Wise et al on Postlicensure Safety Surveillance for Varicella Vaccine

But that study just looked at the chicken pox vaccine and used VAERS, so we have to be concerned about under-reporting, right? Well, not necessarily. Under-reporting likely isn’t a big problem for serious reactions.

Anyway, that’s not the only study…

“We identified 33 confirmed vaccine-triggered anaphylaxis cases that occurred after 25,173,965 vaccine doses. The rate of anaphylaxis was 1.31 (95% CI, 0.90-1.84) per million vaccine doses.”

McNeill et al on Risk of anaphylaxis after vaccination in children and adults

The McNeill study used the Vaccine Safety Datalink, which unlike VAERS, is not a passive reporting system. So there is no concern about underreporting.

And like the Wise study, there were no deaths among these vaccine-triggered anaphylaxis cases.

“Fatalities from vaccine-induced anaphylaxis are exceedingly rare.”

Adverse reactions to vaccines practice parameter 2012 update

Similarly, a study in the UK found rare reports of anaphylaxis after vaccines in children and all those children made a full recovery.

Parents should understand that while anaphylaxis is a known side effect to getting a vaccine, it is extremely rare, and can usually be treated. This once again reinforces that vaccines are safe!

More on Anaphylaxis After Vaccines

Inappropriate Use of Vaccine Studies

Have you ever wondered how anti-vaccine do their vaccine research?

These types of binders of anti-vaccine information are typically filled with vaccine studies that folks end up misusing to scare parents away from vaccinating and protecting their kids.
These types of binders of anti-vaccine information are typically filled with vaccine studies that folks end up misusing to scare parents away from vaccinating and protecting their kids.

While they used to have to rely on Google University for their vaccine research, they now have folks making them ready made binders chock full of misinformation!

Misusing Vaccine Studies

As with their misuse of Google and Pubmed, a lot of the problems with these binders is that anti-vaccine folks cherry pick studies that support what they want to hear.

And in many cases, they read things into studies, thinking they support their views against vaccines, when they really don’t.

You're not gonna catch measles from someone's urine....
You’re not gonna catch measles from someone’s urine….

Is this 1995 study, Detection of Measles Virus RNA in Urine Specimens from Vaccine Recipients, a warning about shedding?

Anti-vaccine folks would sure like you to think so, but the thing is, measles is a respiratory illness.

“In this systematic review, we have determined that there have been no confirmed cases of human-to-human transmission of the measles vaccine virus.”

Greenwood et al on A systematic review of human-to-human transmission of measles vaccine virus

Detecting vaccine strain measles in urine isn’t something to be concerned about because it can’t lead to an infection.

Anyway, you’re not going to get measles from shedding after someone was vaccinated. If you do, you will be the first!

Misusing MTHFR Tests

Have you wondered why anti-vaccine are so concerned about their MTHFR test results?

“In conclusion, the invalid interpretation that the determination of the MTFHR variant is an acceptable reason for vaccine exemptions is not based on the precepts of replication and rigorous clinical testing. It is unfortunate that the loose application of our exploratory report has been misinterpreted and used to inappropriately justify exemption of children from medically indicated vaccines.”

David M Reif, Ph.D. on the Inappropriate Citation of Vaccine Article

Turns out it is because a few anti-vaccine doctors misinterpretated an old study about the smallpox vaccine.

Now that the author of that study has called them out, will they stop?

Other Vaccine Studies That Are Misused

Of course, there are more…

The article totally misinterpretated the study...
The article totally misinterpretated the study…

Remember when anti-vaccine folks thought that the polio vaccine was causing outbreaks of hand, foot and mouth disease?

“Well, that’s actually totally backwards. Our article suggests that FAILURE to get vaccinated with polio vaccine might set you up for Hand Food Mouth disease (EV71).”

It wasn’t…

And then there is the study that had anti-vaccine folks thinking that 38% of the kids in the Disneyland measles outbreak were vaccinated.

This isn't a study about vaccine-associated measles...
This isn’t a study about vaccine-associated measles…

The study was about new ways to detect measles vaccine reactions.

“During measles outbreak investigations, rapid detection of measles vaccine reactions is necessary to avoid unnecessary public health interventions.”

Roy et al on Rapid Identification of Measles VirusVaccine Genotype by Real-Time PCR

These are folks with a fever and a rash after their MMR vaccine.

This is not people with vaccine-associated measles.

Misusing Scientific Research

Remember when they thought that the study, Deaths Reported to the Vaccine Adverse Event Reporting System, United States, 1997–2013, reported that 79% of deaths in VAERS occurred on the day a child received a vaccine?

Did they read the study?
Did they read the study?

That’s not what the study said…

The study simply said that “For child death reports, 79.4% received >1 vaccine on the same day.”

It wasn’t the same day they died though.

“No concerning pattern was noted among death reports submitted to VAERS during 1997–2013.”

Moro et al on Deaths Reported to the Vaccine Adverse Event Reporting System

In fact, the study “did not detect any concerning patterns that would suggest causal relationships between vaccination and deaths.”

What about when anti-vaccine folks say that only 1% of vaccine side effects are reported to VAERS? That has to be true, right?

Not exactly.

That claim is based on an old study about drug reactions and was not specific to vaccines.

“To counter the propaganda by anti-vaccine activists, the research and public health communities have to adjust their communication.”

Stephan Guttinger on The anti-vaccination debate and the microbiome

Does any of this surprise you?

Can we counter this type of anti-vaccine propaganda and keep it from scaring parents away from vaccinating and protecting their kids?

Sure.

But first we all have to recognize that they are doing it!

More on Misusing Vaccine Studies

Del Bigtree’s Caught on Tape Claim

Del Bigtree responded predictably to John Rushing’s report, The Viral Threat: Measles and Misinformation.

Why doesn't Del just explain what he said in the interview?
Why doesn’t Del just explain what he said in the interview?

Del, who produced VAXXED, complains that it was a one-sided hit piece. And implies that his interview was the result of editing.

Behind the Scenes with Del Bigtree

Del was given a lot more than just a words in the final edit.

For example, when given an opportunity, Del doesn’t explain his own conflict of interests because he doesn’t seem understand them.

“I’m simply finding the information as I find it.”

Del Bigtree

And if you notice, there are no cuts in Del Bigtree’s scenes.

John Rushing: The numbers the way you’re using them though, it implicitly warns against using them that way.

Del Bigtree: Yeah. Yes.

John Rushing: You’re saying that there are 412 deaths last year.

Del Bigtree: I – no. What I’m saying is there’s 412 reported deaths. I never said there were 412 confirmed deaths reported.

John Rushing: So, so some of those causes of death on VAERS

Del Bigtree: Yeah.

John Rushing: one was a drowning.

Del Bigtree: Sure.

John Rushing: One was from co-sleeping. One was from a pre-existing heart condition. There’s no – because a death is reported in VAERS – there’s no way to show causation to the vaccine.

Del Bigtree: Okay.

John Rushing: But in watching your speech and watching your show – man, you would come away thinking 400 people died from vaccines last year.

Del Bigtree: Okay.

John Rushing: And then I can start to see

Del Bigtree: Okay.

John Rushing: where they get the number. And then I go to the source and the source says “don’t use the number that way.”

The Viral Threat: Measles and Misinformation

Del wants you to think that he had a lot more to say in those scenes, things that were edited out, but Rushing didn’t cut away.

Del knows that the deaths in VAERS aren’t confirmed vaccine deaths, even though he never says that on his show. But if he explained that, he wouldn’t be able to scare people with “vaccine deaths” anymore.

Del Bigtree’s Caught on Tape Claim

There is also no “big reveal” as the HIGHWIRE cameras kept rolling, as Del claims.

“I vaccinated mine, but I wasn’t aware of this issue. Although one of my neighbors, who is very intelligent and who I respect a lot, who did vaccinate their kids and one of them has autism. Uh, is a believer in this and she sent me, well a ton of your information before I started this story. And we don’t invalidate the way people like her feel at all.”

John Rushing

Or any “other side” of John Rushing that agreed with Del Bigtree.

What does he agree to at the end of his talk with Del?

Del is explaining how he doesn’t think that parents are making a knee-jerk reaction when they blame vaccines for their “injured children.”

“Yeah, I agree.”

John Rushing

What is he agreeing to?

Del Bigtree is once again caught using messaging that hurts autistic families.
Del Bigtree is once again caught using messaging that hurts autistic families.

Maybe he is agreeing that parents aren’t making a knee-jerk reaction, but more than anything, it sounds like he is just being polite.

He is certainly not agreeing with Del that there are no safety studies, that VAERS is a slopping system, or even that parents should blame themselves.

Not surprisingly, Del’s caught on tape claims were enough to satisfy his followers, who have already forgotten that he admitted to misleading them about VAERS reports. Hopefully, they soon realize that misinformation about vaccines is keeping them from vaccinating and protecting their kids.

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