Tag: pertussis deaths

Does Getting the DTaP Vaccine Make You More Susceptible to Pertussis?

Wait, why would anyone think that getting vaccinated would make you more likely to get a vaccine-preventable disease?

Because there is a new pertussis outbreak in California and folks don’t understand how attack rates work…

Does Getting the DTaP Vaccine Make You More Susceptible to Pertussis?

We know that the latest pertussis vaccines aren’t the greatest, having issues with waning immunity.

They don’t actually make you more likely to get pertussis though, at least not relative to being unvaccinated.

“Because of linked-epitope suppression, all children who were primed by DTaP vaccines will be more susceptible to pertussis throughout their lifetimes, and there is no easy way to decrease this increased lifetime susceptibility.”

JD Cherry on The 112-Year Odyssey of Pertussis and Pertussis Vaccines-Mistakes Made and Implications for the Future

What the above quote that anti-vaccine folks are misusing is actually saying is that kids who got DTaP vaccines will be more susceptible to pertussis compared to those who got DTwP, the older version of the vaccine. That’s what the whole article is about!

It is not that they will be more suspecptible to pertussis vs someone who was unvaccinated.

Dr. I: Anti-vax folks are misinterpreting that statement, not understanding that it means relative to kids who got DTwP. They think that you are saying that it is the DTaP vaccine itself that makes it more likely that a child will get pertussis, in general. Even relative to someone who is unvaccinated. I know it shouldn’t be necessary, but can you provide a simple quote to clarify this?

JDC: You are of course correct. I was asked to write-up the talk that I have given many times in the US and in many other countries. In the talk, right at the beginning, I mention that today there is 20 fold less pertussis than there was in the pre-vaccine era and that illness in vaccine failures is much less severe that illness in unvaccinated children. I also remember how wrong they were 30 years ago R/E alleged reactions to DTwP.

And if you read his latest article, The 112-Year Odyssey of Pertussis and Pertussis Vaccines-Mistakes Made and Implications for the Future, especially if you read more than the abstract, you discover that’s what he is saying.

But what about linked-epitope suppression?

In “linked-epitope suppression,” memory B cells out-compete naive B cells for access to the Bordetella epitopes because they are more numerous and their receptors exhibit a higher antigen affinity. Linked-epitope suppression applies as the immune response to novel epitopes is suppressed by the strong response to initial components if they are introduced together.

JD Cherry on The 112-Year Odyssey of Pertussis and Pertussis Vaccines-Mistakes Made and Implications for the Future

Basically, the DTwP vaccine included many more epitopes or targets for antibodies to bind to than the newer DTaP vaccine. That’s why it worked better. And you don’t get a good response to non-vaccine epitopes or antigens.

Still, you at least have some memory B cells and antibodies after getting the DTaP vaccine, which is why the idea that getting vaccinated makes you more susceptible to pertussis is silly. You are still protected, even if the protection isn’t perfect.

That’s why Dr. Cherry recommends that folks continue to get vaccinated and protected!

“We should be more vigilant than we have been in the past to recognize and treat pertussis in all age groups so that transmission to young infants is reduced. Most important (although not discussed in this review) is to ensure that all pregnant women receive the Tdap vaccine between 27 and 36 weeks’ gestation with each pregnancy. Also, we should consider routinely administering Tdap vaccine every 3 years to all adolescents and adults who were primed with a DTaP vaccine. This suggestion is contrary to that in the current Advisory Committee on Immunization Practices recommendations. However, from the data available, this approach could be expected to decrease the circulation of B pertussis in adolescents and adults. Also, Tdap should be administered to all adolescent and adults exposed to B pertussis during a school or other group outbreak.”

JD Cherry on The 112-Year Odyssey of Pertussis and Pertussis Vaccines-Mistakes Made and Implications for the Future

He does recommend that we work on new pertussis vaccines though.

“Future cohorts would benefit from the development and use of live vaccines and less-reactogenic DTwP vaccines.”

JD Cherry on The 112-Year Odyssey of Pertussis and Pertussis Vaccines-Mistakes Made and Implications for the Future

But why are we using a vaccine that doesn’t work as well as the previous vaccine we had?

“Despite the fact that in all but 2 of the efficacy trials the DTwP vaccines had greater efficacy than did the DTaP vaccines being studied, DTaP vaccines were licensed and used in many countries throughout the world; DTaP vaccines had replaced DTwP vaccines. The urgency to adopt DTaP vaccines was driven largely by antivaccine activist groups such as “Dissatisfied Parents Together.” During the rush to adopt DTaP vaccines and tetanus, diphtheria, acellular pertussis vaccines for adults (Tdap), much of the history relating to human pertussis was overlooked.”

JD Cherry on The 112-Year Odyssey of Pertussis and Pertussis Vaccines-Mistakes Made and Implications for the Future

But the DTwP vaccines weren’t safe, right?

“The results of a number of controlled studies between 1979 and 2004 indicated that no risk of severe neurologic disease after DTwP vaccinations existed. It was noted by myself and Shields (a pediatric neurologist) that what was being called pertussis vaccine encephalopathy was not an encephalitis-like event but, instead, the first seizure or seizures of infantile epilepsy.”

JD Cherry on The 112-Year Odyssey of Pertussis and Pertussis Vaccines-Mistakes Made and Implications for the Future

No, the cases of encephalopathy that were being reported were not caused by the DTwP vaccine. And neither did the DTwP vaccine cause SIDS, as was also reported at the time.

“Since 1997, the DTaP vaccination policy has created a cohort of people (the number of which is expanding yearly) who are more susceptible to repeated clinical illness with B pertussis infection than are DTwP-vaccinated children. There is no feasible way to make this cohort less susceptible.”

JD Cherry on The 112-Year Odyssey of Pertussis and Pertussis Vaccines-Mistakes Made and Implications for the Future

And now, after helping create the current DTaP vaccination policy, anti-vaccine folks want to scare folks away from using the vaccine. Don’t let them. Don’t skip or delay this vaccine and leave your kids susceptible to getting diphtheria, tetanus, and pertussis.

More on Does Getting the DTaP Vaccine Make You More Susceptible to Pertussis?

What Do Anti-Vaccine Folks Actually Know About Vaccines?

Anti-vaccine folks are spreading another quiz around…

It’s not the questions that automatically makes you think the quiz is anti-vaccine though. It’s how you just know anti-vaccine answers will be very different from someone who actually does know something about vaccines.

What Do Anti-Vaccine Folks Actually Know About Vaccines?

If you are anti-vaccine, you likely believe that vaccines are dangerous, full of toxins, and that they don’t even work. That gives other folks a giant hint as to how you would answer these 32 questions…

1. Can you name 5 vaccine ingredients?
Yes. I can also name what’s not in vaccines, including heavy metals, hidden ingredients, toxins, antifreeze, lead, glyphosate, vaginal spermicides, etc.
AV answerall vaccines contain toxic ingredients!
2/3. What is MRC-5/WI-38?
These are immortalized cell lines that are used to make some vaccines. These cell lines are derived (they can replicate infinitely) from fetal embryo fibroblast cells from two electively terminated pregnancies (abortions) in the 1960s. The cells used today are descendants of the original cells.
AV answerthere are aborted baby parts in our vaccines!
4. What is vaccine court?
The Vaccine Court is part of the National Vaccine Injury Compensation Program (VICP) and decides if the claims should be compensated or dismissed, etc.
AV answervaccine court proves that vaccine injuries are real.
5. What is the National Vaccine Injury Compensation Program?
The National Vaccine Injury Compensation Program (VICP) was created as “a no-fault alternative to the traditional legal system for resolving vaccine injury petitions.”
AV answerthe National Vaccine Injury Compensation Program (VICP) proves that vaccine injuries are real.
6. What is the 1986 National Childhood Vaccine Injury Act?
The National Childhood Vaccine Injury Act of 1986 established the VICP, the Vaccine Injury Compensation Trust Fund, the National Vaccine Program Office, VAERS, and required that health care providers give a Vaccine Information Statement to anyone getting a vaccine.
AV answerthe 1986 National Childhood Vaccine Injury Act should be repealed because it removed all liability from vaccine manufacturers.
7. How has the CDC schedule changed since 1986?
The immunization schedule has changed to include vaccines to protect kids against meningitis, pneumonia, blood infections, severe dehydration, epiglottitis, and cancer from Hib, pneumococcal disease, rotavirus, hepatitis B, hepatitis A, chicken pox, HPV, and meningococcal disease.
AV answerit has ballooned and exploded with 300 more vaccines in the pipeline!
8. How much money has been paid out by vaccine injury court?
Since the National Vaccine Injury Compensation Program began, in 1988, almost $3.5 billion dollars have been paid out for 4,899 compensated awards, the majority of which were settled, and during which time over 2.5 billion doses of vaccines were given.
AV answer$3.5 billion dollars, which proves that vaccine injuries are real!
9. How many doses of vaccines are in the CDC schedule between birth and age 18?
By age 18 years, today’s kids get 54 doses of 13 vaccines that protect them against 16 vaccine-preventable diseases, with a third of those doses coming from yearly flu vaccines.
AV answer72 doses!
10. Do vaccines contain DNA from aborted fetal cell lines? If so, which vaccines?
Residual, highly fragmented DNA is sometimes found in vaccines that are made using the MRC-5/WI-38 cell lines.
AV answervaccines contain aborted fetal tissue.
11. Do any vaccines contain dog, monkey, pig, or human DNA?
Residual DNA, if found in vaccines, is not a cause for concern. It is typically a function of growing vaccine viruses in mammalian cell lines.
AV answerdog, monkey, pig, and human DNA contaminate vaccines and will turn us all into mutant dog-monkey-pig-human hybrids.
12. What is an adjuvant?
An adjuvant in a vaccine can increase the body’s immune response to an antigen, allowing you to use a smaller amount of antigen, which is important, as it is the antigens that typically cause side effects.
AV answerAdjuvants in vaccines have never been tested and they trigger vaccine injuries and disease.
13. What is an antigen?
An antigen is a substance, often part of a virus or bacteria, that can stimulate an immune response and the production of antibodies. Surprisingly, even though kids get more vaccines than they used to, those vaccines contain far fewer antigens than older vaccines.
AV answerwe don’t care about antigens anymore, because all of the other vaccine ingredients are toxic.
14. Which arms of the immune system do vaccines stimulate?
It actually depends on the vaccine, but this is about the differences between innate (nonspecific and without memory) and adaptive immunity, which typically interact with each other, whether it is to create natural or vaccine induced immunity.
AV answerI don’t care which arm you try to give it to them, my kids aren’t getting vaccinated!
15. Which arms of the immune system do natural diseases stimulate?
As with vaccines, it depends on the disease.
AV answerEven if you offer to give the shot in their legs, my kids aren’t getting vaccinated!
16. What is transverse myelitis?
Transverse myelitis is a type of inflammation of the spinal cord, causing weakness and paralysis, and typically triggered by infections, immune system, inflammatory, and vascular disorders.
AV answertransverse myelitis is a vaccine injury.
17. What is encephalopathy?
Almost anything can cause encephalopathy, leading to diffuse brain disease and dysfunction.
AV answerencephalopathy is a vaccine injury.
18. What is the rate of autism in 2018? What was it in 2000? What was it in 1980?
The reported rate of autism has increased since 1980 because of better recognition, diagnostic substitution, broadening of the diagnostic criteria, and social influences. Vaccines are not associated with autism.
AV answervaccines cause autism. If it isn’t the MMR vaccine, then it is thimerosal, or maybe aluminum. Or it could be glyphosate. It is definitely vaccines though.
19. What is glyphosate? Is it in vaccines?
Glyphosate, a weed killer (Roundup) made by Monsanto is not in any vaccines.
AV answerbecause glyphosate is everywhere, including in vaccines, half of all children will be autistic by 2025.
20. If your child is injured who will take physical, emotional and financial responsibility?
If a child has a true vaccine injury, compensation from the National Vaccine Injury Compensation Program (VICP) will hopefully help with your financial responsibilities.
AV answeryou can not sue vaccine manufacturers, so they have no liability if your child is injured by a vaccine.
21. What was the Supreme Courts statement on vaccines in 2011?
In 2011, the Supreme Court decided Bruesewitz v. Wyeth, in which they used the infamous unavoidably unsafe terminology, which has been misunderstood by anti-vaccine folks ever since.
AV answerthe Supreme Court said that vaccines can never be safe.
22. Can you find a study showing vaccinated vs unvaccinated health outcomes?
Yes, yes I can. A large study, “Vaccination Status and Health in Children and Adolescents Findings of the German Health Interview and Examination Survey for Children and Adolescents (KiGGS),” found that unvaccinated kids weren’t healthier, they just had more measles, mumps, rubella, and pertussis.
AV answerthe Mawson study (published in a pay-to-publish journal after being retracted two other times) proves that unvaccinated (homeschooled) kids are healthier than vaccinated (homeschooled) kids.
23. Can you find a safety study proving it is safe to inject multiple vaccines?
Yes, yes I can. There are many studies that prove that it is safe to give multiple vaccines at the same time.
AV answervaccines have never been tested together.
24. Do vaccines shed?
A few vaccines do shed, including the rotavirus vaccines (in stool, so wash your hands when changing diapers) and oral polio vaccines, which haven’t been used in the United States since 2000. Although FluMist can shed, since the vaccine contains attenuated viral strains of the flu that are temperature-sensitive, it isn’t a problem, except maybe for someone who is severely immunocompromised.
AV answerour unvaccinated kids are at risk during shedding season!
25. Which vaccines can shed for up to 6 weeks?
The oral polio vaccine, which hasn’t been used in the United States since 2000, can likely shed for up to 6 weeks. This type of shedding is one of the reasons this weakened live virus vaccine is preferred over the inactivated polio vaccine when polio is still common in an area. In areas with poor hygiene and sanitation, the shedding (in stool) can lead to a type of passive immunization and improved herd immunity!
AV answershedding season is coming!
26. Which vaccines are live virus vaccines?
Attenuated, live virus vaccines which contain a weakened version of a virus include MMR, Varivax (chicken pox), the rotavirus vaccines, FluMist, the yellow fever vaccines, the oral polio vaccine, and vaccines against typhoid, cholera, adenovirus, and smallpox.
AV answerunvaccinated children are at risk from shedding if they are around kids who have gotten a live virus vaccine, especially during shedding season.
27. What is the Vaccine Injury Compensation Program (VICP)?
This is the same thing as the National Vaccine Injury Compensation Program (VICP) in question 5…
AV answerwe need to repeal both the NVICP and the VICP!
28. What is SV40?
Simian virus 40 was found to contaminate polio vaccines from 1955 through 1963. Fortunately, it has not been found to cause any disease in the folks who got those vaccines.
AV answervaccines are contaminated with monkey viruses and cause cancer.
29. What is MTHFR and how does it affect the body’s response to vaccines?
True MTHFR gene mutations rarely cause homocystinuria. Folks are more likely to hear about MTHFR polymorphisms, which are typically normal and have no affect on vaccines or anything else.
AV answerno one should not get vaccinated if they have MTHFR mutations or signs of MTHFR.
30. What is an acceptable amount of aluminum to be ingested per day versus the aluminum content in the Hep B shot given at birth, 2 months, and then again at 4 months?
Although there are limits on aluminum that premature neonates and infants getting daily intravenous fluids and IV feeding solutions over prolonged periods of time, that doesn’t mean that aluminum in vaccines that infants get every few months isn’t safe. It is. And they are.
AV answerinfants are getting toxic amounts of aluminum in their vaccines!
31. Can someone who was vaccinated for pertussis still spread pertussis after being exposed to it? If so, for how long?
Maybe. A study in baboons said it is possible. More importantly though, you are much more likely to get pertussis if you are unvaccinated, will have more severe symptoms, and will likely get more people sick.
AV answervaccinated people are the ones starting pertussis outbreaks.
32. What is the death rate from measles in the past 10 years in the U.S. compared to the death rate from the MMR vaccine in the past 10 years?
Deaths from measles are now rare in the United States because most people are vaccinated and protected. And unless you are looking at VAERS reports, the deaths from the MMR vaccine are also very rare. We will have more and more measles outbreaks if folks don’t get vaccinated though, increasing the risk of another measles death.
AV answermeasles is a mild disease that was on the Brady Bunch, and MMR is an unnecessary vaccine kills tons of people.

How did you answer the questions?

What Do Anti-Vaccine Folks Actually Know About Vaccines?

Have Normal Childhood Diseases Become More Deadly?

Weren’t measles and chicken pox once a rite of passage for kids?

Yes, in the pre-vaccine era, almost all kids got measles, chicken pox, and other now vaccine-preventable diseases in early childhood.

It was considered a rite of passage.

That she doesn't understand survivorship bias doesn't mean that you shouldn't vaccinate your kids.
That she doesn’t understand survivorship bias doesn’t mean that you shouldn’t vaccinate your kids.

But these diseases were never benign.

They were considered a rite of passage only because we all had to endure them. They weren’t something anyone looked forward to.

Benign diseases don't kill kids.
Benign diseases don’t kill kids.

After all, you don’t typically die from a benign disease.

Have Normal Childhood Diseases Become More Deadly?

But what about the idea that folks never used to worry about these diseases, at least not until vaccines were developed? Or that we only fear diseases that are vaccine-preventable?

It’s easy to say that no one worried about measles in the pre-vaccine era when you are just trying to scare folks away from getting vaccinated.

That’s one of the more ridiculous arguments anti-vaccine folks make.

A measles epidemic hit New York City in 1951, as this front page NYTimes article reports.
A measles epidemic hit New York City in 1951 and made headlines in the New York Times. That’s not surprising, as there were 683 measles deaths in the United States that year.

And also one of the easiest to refute.

When was the last time that you saw a headline warning about congenital rubella syndrome?
When was the last time that you saw a headline warning about congenital rubella syndrome?

These diseases that are now vaccine-preventable routinely made headlines in the pre-vaccine era.

Even the schools were closed in San Antonio when polio came to Texas in 1946.
Even the schools were closed in San Antonio when polio came to Texas in 1946.

And it was surviving these diseases that was considered a rite of passage, at least for those who were fortunate enough to survive.

So no, childhood diseases have not become deadlier.

They have always been serious and life-threatening!

Of course, not everyone died who got them, but they were rarely a walk in the park. Remember, even a mild case of measles includes a high fever for 4 to 7 days. That’s why folks often end up seeking medical attention multiple times, even if they don’t end up having any complications and don’t need to get admitted to the hospital

Lassie got shot, but ended up saving the day, getting help for Timmy, after they ran out of gas taking a short cut rushing home.
The Lassie episode about measles, in 1958, was called ‘The Crisis.” There were 552 measles deaths in the United States that year.

But what about the Brady Bunch measles episode, Is There a Doctor in the House? Is that really why you think vaccine-preventable diseases are mild?

In 1969, when that episode first aired, there were 25,826 reported cases and 41 deaths from measles in the United States.

Why don’t we see that many deaths now?

That’s easy.

We don’t see as much measles now. Most folks are vaccinated and protected.

If more people skip or delay their vaccines though, we will see more and more outbreaks, with greater chances that people will die.

Believe it or not, we still don’t have cures for measles, chicken pox, congenital rubella syndrome, and hepatitis B, etc. So while these diseases haven’t become any more deadly, they haven’t become any less deadly either, even with all of the advances of modern medicine.

More on Childhood Diseases as a Rite of Passage

Do More Vaccinated or Unvaccinated Kids Get Pertussis?

While this seems like a simple question, the answer is a bit more complicated than most people imagine.

Do More Vaccinated or Unvaccinated Kids Get Pertussis?

For anti-vaccine folks, the answer is clear – more vaccinated kids get pertussis. They put all of the blame for pertussis outbreaks on waning immunity. Of course, that’s not the whole story.

While 10% of kids got pertussis, unless you are at a Waldorf school, it is unusual to find that many completely unvaccinated children.
While 10% of kids got pertussis, unless you are at a Waldorf school, it is unusual to find that many completely unvaccinated children. Plus, we don’t know the vaccine history of 40% of these kids.

While it might technically be true that more vaccinated kids get pertussis in the average outbreak, that’s only because there are many more vaccinated kids!

A more accurate and useful answer, taking into account attack rates, makes it clear that a higher percentage of unvaccinated kids get pertussis in these outbreaks.

“In conclusion we have described a school-based outbreak of pertussis that may have been fueled by moderate vaccine effectiveness combined with a failure to vaccinate.”

Terrenella et al on Vaccine effectiveness of tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis vaccine during a pertussis outbreak in Maine

In a pertussis outbreak in Maine, attack rates were much higher in unvaccinated kids, even though more vaccinated kids got pertussis. While 29 of 214 vaccinated kids got pertussis, a much higher percentage of unvaccinated kids got sick – 6 of 28.

That means your risk of getting pertussis was much higher if you were unvaccinated.

A 2013 pertussis outbreak in Florida is a good example that even with all the bad press it gets, the DTaP and Tdap vaccines work too. This outbreak was started by an unvaccinated child at a charter school with high rates of unvaccinated kids. About 30% of unvaccinated kids got sick, while there was only one case “in a person who reported having received any vaccination against pertussis.”

In another 2013 pertussis outbreak in Florida, this time in a preschool, although most of the kids were vaccinated, the outbreak started with “a 1-year-old vaccine-exempt preschool student.” And the classroom with the highest attack rate, was “one in which a teacher with a laboratory-confirmed case of pertussis who had not received a Tdap booster vaccination, worked throughout her illness.”

Why do so many unvaccinated kids get pertussis these days?

“We found evidence of an increase in exemption rates, spatial clustering of nonmedical exemptions, and space-time clustering of pertussis in Michigan. There was considerable overlap between the clusters of exemptions and the clusters of pertussis cases.”

Omer et al on Geographic Clustering of Nonmedical Exemptions to School Immunization Requirements and Associations With Geographic Clustering of Pertussis

Besides the fact that they are unvaccinated and unprotected?

“Children of parents who refuse pertussis immunizations are at high risk for pertussis infection relative to vaccinated children. Herd immunity does not seem to completely protect unvaccinated children from pertussis.”

Glanz et al on Parental refusal of pertussis vaccination is associated with an increased risk of pertussis infection in children.

They can’t get away with hiding in the herd.

Another important consideration – in addition to the fact that more unvaccinated kids get pertussis, when they get pertussis, it is more severe than those who are vaccinated.

“Serious pertussis symptoms and complications are less common among age-appropriate number of pertussis vaccines (AAV) pertussis patients, demonstrating that the positive impact of pertussis vaccination extends beyond decreasing risk of disease.”

McNamara et al on Reduced Severity of Pertussis in Persons With Age-Appropriate Pertussis Vaccination-United States, 2010-2012.

Still thinking of skipping or delaying your child’s pertussis vaccine?

More on Do More Vaccinated or Unvaccinated Kids Get Pertussis?