Tag: vaccine pipeline

Choose to Stop Spreading Anti-Vaccine Propaganda

You have a choice.

Right now.

You can continue to share and spread anti-vaccine propaganda, helping scare other folks away from vaccinating and protecting their kids, or you can stop.

Choose to Stop Spreading Anti-Vaccine Propaganda

Why is the above meme anti-vaccine propaganda?

For one thing, there aren’t 200 vaccines in the pipeline!

There are actually very few new vaccines being developed that have any chance of making it onto the immunization schedule anytime soon. Many of the so-called vaccines in the pipeline are either not for infectious diseases (many are therapeutic vaccines for cancer!) or are for the same disease.

Even more importantly though, removing non-medical vaccine exemptions, which are often abused, doesn’t force anyone to vaccinate their kids.

Vaccine mandates are laws about getting vaccinated to attend daycare and school, etc. You still have a choice if you don’t want to get vaccinated.

What’s the problem that some folks have?

They don’t like their choices!

They want to be able to skip or delay their child’s vaccines and be able to send them to daycare or school.

“…the increased risk of disease in the pediatric population, in part because of increasing rates of vaccine refusal and in some circumstances more rapid loss of immunity, increases potential exposure of immunodeficient children.”

Medical Advisory Committee of the Immune Deficiency Foundation

And they want to take away everyone else’s choice to decrease their risk of getting a vaccine-preventable disease.

You don’t have a right to do that though!

Are you still spreading anti-vaccine propaganda?

Then you are part of the problem. You just don’t realize it yet.

And you are the reason that rates of vaccine-preventable diseases are going up and why Legislators are having to tighten the rules to prevent exemption abuse.

More on Choosing to Stop Spreading Anti-Vaccine Propaganda

Where are the Saline Placebos?

Remember when anti-vaccine folks used to say that there were no double-blind, placebo-controlled randomized clinical trials for vaccines?

What happened once they realized that there actually were?

They moved the goal posts…

Where are the Saline Placebos?

Okay, they said.

So you have done double-blind, placebo-controlled randomized clinical trials when testing vaccines, but what placebo did you use?

Was it a pure saline placebo?

“Placebo Control – A comparator in a vaccine trial that does not include the antigen under study. In studies of monovalent vaccines this may be an inert placebo (e.g. saline solution or the vehicle of the vaccine), or an antigenically different vaccine. In combined vaccines, this may be a control arm in which the component of the vaccine being studied is lacking.”

WHO on the Guidelines on clinical evaluation of vaccines: regulatory expectations

Although no guidelines actually call for using a pure saline placebo, that’s all anti-vaccine folks will accept these days.

Why?

That’s their MO – or method of operation.

When one theory or myth gets squashed – they move to another.

They move the goalposts.

It doesn’t matter that there are often ethical and logistical problems with using pure saline placebos, that’s all they want to hear about it.

That they wouldn’t be satisfied and start vaccinating their kids if all vaccine studies started to use saline placebos should be evident when you consider that many vaccine studies have already used saline placebos!

There are many more vaccine studies that have used saline placebos and like other vaccine studies, have found vaccines to be safe and effective.

But how do you know that they used a real saline placebo and not some kind of saline solution with other stuff in it?

If it isn’t clear to you in the methods section of the study, go to the source – the original clinical trials record and it will be listed there.

What are you going to be worried about now?

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Are You Ready for DNA Vaccines?

Believe it or not, vaccines aren’t a one-size-fits-all kind of a thing.

“There are several different types of vaccines. Each type is designed to teach your immune system how to fight off certain kinds of germs — and the serious diseases they cause.”

Vaccine Types

In addition to live vaccines, like MMR, there are inactivated vaccines, toxoid vaccines, and subunit, recombinant, polysaccharide, and conjugate vaccines.

Are You Ready for DNA Vaccines?

Vaccines made with current technology have helped save millions of lives.

It’s time for some new approaches though, especially as we are seeing the limitations of some of our current vaccines, especially the seasonal flu vaccine.

“DNA vaccines take immunization to a new technological level. These vaccines dispense with both the whole organism and its parts and get right down to the essentials: the microbe’s genetic material. In particular, DNA vaccines use the genes that code for those all-important antigens.”

NIH on Vaccine Types

While a DNA vaccine might sound like something out of the 23rd century, researchers have been studying them since the 1990s.

“Researchers have found that when the genes for a microbe’s antigens are introduced into the body, some cells will take up that DNA. The DNA then instructs those cells to make the antigen molecules. The cells secrete the antigens and display them on their surfaces. In other words, the body’s own cells become vaccine-making factories, creating the antigens necessary to stimulate the immune system.”

NIH on Vaccine Types

Does the idea of being injected with the genes for a microbe’s antigens scare you?

“The original concerns associated with the DNA platform were the potential for genomic integration and development of anti-DNA immune responses. Exhaustive research has found little evidence of integration, and the risk for integration appears to be significantly lower than that associated with naturally occurring mutations”

Ferraro et al on Clinical Applications of DNA Vaccines: Current Progress

What do you think happens when you get the flu?

The flu virus and it’s DNA is taken up by your cells, and those cells then start making more flu proteins.

“This approach offers a number of potential advantages over traditional approaches, including the stimulation of both B- and T-cell responses, improved vaccine stability, the absence of any infectious agent and the relative ease of large-scale manufacture.”

WHO on DNA Vaccines

So where are all of the DNA vaccines?

“However, the results of these early clinical trials were disappointing. The DNA vaccines were safe and well tolerated, but they proved to be poorly immunogenic. The induced antibody titers were very low or nonexistent, CD8+ T-cell responses were sporadic, and CD4+ T-cell responses were of low frequency. However, these studies provided proof of concept that DNA vaccines could safely induce immune responses (albeit low-level responses) in humans.”

Ferraro et al on Clinical Applications of DNA Vaccines: Current Progress

After getting disappointing results in the 1990s, researchers have since moved on to second-generation DNA vaccines, which are being tested for HIV treatment and prevention, Zika, Dengue fever, influenza (DNA vaccine prime), HPV, cancer treatment (metastatic breast, B cell lymphoma, melanoma, prostate, colorectal), chronic hepatitis B treatment, chronic hepatitis C treatment, herpes, and malaria.

There are many completed trials for DNA vaccines.
There are already many completed trials for DNA vaccines.

While many of these DNA vaccines are now in phase I and II trials, unfortunately, that means we are still a long time away from having a DNA vaccine on the immunization schedule.

More on DNA Vaccines

How Are Vaccines Related to News About Food Recalls and Food Poisoning?

Do you ever think about vaccines when you think about food recalls?

How about when you think about food poisoning?

Well, maybe you should, after all, we do have vaccines to prevent hepatitis A infections and typhoid fever, both are which can be spread through contaminated food.

How Are Vaccines Related to News About Food Recalls and Food Poisoning?

That’s not exactly what we were talking about though…

Anti-vaccine folks have a new conspiracy theory about food recalls and food poisoning.
Surprise! Anti-vaccine folks have a new conspiracy theory about food recalls and food poisoning. How often do these types of posts correlate with the truth? What do you guys think? Zero?

That’s right, some folks think that the recent food recalls are correlated to vaccines. They are “creating a market” for a new Salmonella enterica serovar Typhimurium vaccine!

“We evaluated the extent of attenuation and immunogenicity of the ΔlppAB and ΔlppAB ΔmsbB mutants of Salmonella enterica serovar Typhimurium when delivered to mice by the oral route.”

Erova et al on Protective Immunity Elicited by Oral Immunization of Mice with Salmonella enterica Serovar Typhimurium Braun Lipoprotein (Lpp) and Acetyltransferase (MsbB) Mutants

At least they are if mice are monitoring our outbreaks and are in the market for a Salmonella enterica serovar Typhimurium vaccine?

How would that work anyway? No, not mice watching the news and ordering vaccines…

Do they actually think that someone is contaminating our food with Salmonella bacteria so that folks will want these vaccines, when they become available?

Food poisoning is horrible!

Whether it is for Listeria, Salmonella, or E. coli, it likely won’t be very hard to get folks vaccinated, if and when they become available.

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