Tag: meningococcal disease

Where are the Saline Placebos?

Remember when anti-vaccine folks used to say that there were no double-blind, placebo-controlled randomized clinical trials for vaccines?

What happened once they realized that there actually were?

They moved the goal posts…

Where are the Saline Placebos?

Okay, they said.

So you have done double-blind, placebo-controlled randomized clinical trials when testing vaccines, but what placebo did you use?

Was it a pure saline placebo?

“Placebo Control – A comparator in a vaccine trial that does not include the antigen under study. In studies of monovalent vaccines this may be an inert placebo (e.g. saline solution or the vehicle of the vaccine), or an antigenically different vaccine. In combined vaccines, this may be a control arm in which the component of the vaccine being studied is lacking.”

WHO on the Guidelines on clinical evaluation of vaccines: regulatory expectations

Although no guidelines actually call for using a pure saline placebo, that’s all anti-vaccine folks will accept these days.

Why?

That’s there MO – or method of operation.

When one theory or myth gets squashed – they move to another.

They move the goalposts.

It doesn’t matter that there are often ethical and logistical problems with using pure saline placebos, that’s all they want to hear about it.

That they wouldn’t be satisfied and start vaccinating their kids if all vaccine studies started to use saline placebos should be evident when you consider that many vaccine studies have already used saline placebos!

There are many more vaccine studies that have used saline placebos and like other vaccine studies, have found vaccines to be safe and effective.

But how do you know that they used a real saline placebo and not some kind of saline solution with other stuff in it?

If it isn’t clear to you in the methods section of the study, go to the source – the original clinical trials record and it will be listed there.

What are you going to be worried about now?

More on Saline Placebos

When You Ask for Vaccine Advice in an Anti-Vaccine Facebook Group…

Can you guess what happens when you ask for advice about vaccines in an anti-vaccine Facebook Group?

Meningitis is not a side effect of vaccines.

What could go wrong?

When You Ask for Vaccine Advice in an Anti-Vaccine Facebook Group…

While most of us are used to hearing about meningococcal meningitis being a big risk for teens and young adults, it is important to realize that rates of disease are also high for infants, with a second peak during adolescence.

The highest rates of meningococcal disease occurs during infancy and adolescence.

So why don’t we routinely vaccinate infants against meningococcal disease?

Many countries do, including Australia and the UK, and in the United States, high risk infants are vaccinated against meningococcal disease.

If you were on the fence but were advised by your paediatrician (Australian spelling) to get vaccinated and protected because a child in your town had just died, would you get vaccinated?

Or would you listen to folks in an anti-vaccine Facebook group who tried to convince you that meningitis was actually a side effect of getting vaccinated?

Folks who insist that deaths from vaccine-preventable disease aren’t real and that instead, they are actually vaccine-injuries?

We know what happens when you ask for vaccine advice in an anti-vaccine Facebook group. The members push their propaganda to scare you away from vaccinating and protecting your kids.

Don’t listen to them. Vaccines are safe and necessary.

More on When You Ask for Vaccine Advice in an Anti-Vaccine Facebook Group…

Is the Meningococcal Vaccine More Dangerous Than Meningococcal Disease?

No one who has ever seen a child with meningococcal disease would ever think that it was even remotely possible that getting a meningococcal vaccine was more dangerous than getting the disease.

“The case-fatality ratio of meningococcal disease is 10% to 15%, even with appropriate antibiotic therapy. The case-fatality ratio of meningococcemia is up to 40%. As many as 20% of survivors have permanent sequelae, such as hearing loss, neurologic damage, or loss of a limb.”

Epidemiology of Vaccine Preventable Diseases (PinkBook)

Of course, that doesn’t stop anti-vaccine folks from spreading misinformation about these vaccines to try and scare parents away from vaccinating and protecting their kids.

Is the Meningococcal Vaccine More Dangerous Than Meningococcal Disease?

We actually vaccinate against meningitis with many different vaccines, including Hib, Prevnar, MMR, and the meningococcal vaccines.

And there are different types of meningococcal vaccines, including those that protect against Neisseria meningitidis serogroups A, C, W, Y and Men B.

Meningococcal vaccines are safe and effective against meningococcemia and meningococcal meningitis, both terrible diseases.
Meningococcal vaccines are safe and effective against meningococcemia and meningococcal meningitis, both terrible diseases.

So routine vaccinations likely prevent up to 500 meningitis deaths each year, just in the United States, including many deaths from Hib meningitis, pneumococcal meningitis, and meningococcal disease.

“During 2005-2011, an estimated 800-1,200 cases of meningococcal disease occurred annually in the United States, representing an incidence of 0.3 cases per 100,000 population.”

Epidemiology of Vaccine Preventable Diseases (PinkBook)

What about the idea that 1 in 100 people will have a serious reaction to the vaccine?

“The most frequently reported adverse events for MenACWY-D include fever (16.8%), headache (16.0%) injection site erythema (14.6%), and dizziness (13.4%). Syncope was reported in 10.0% of reports involving MenACWY-D. Of all reported MenACWY-D events, 6.6% were coded as serious (i.e., resulted in death, life-threatening illness, hospitalization, prolongation of hospitalization, or permanent disability). Serious events included headache, fever, vomiting, and nausea. A total of 24 deaths (0.3%) were reported.”

Epidemiology of Vaccine Preventable Diseases (PinkBook)

The serious events listed above were from the clinical trials for the vaccine and didn’t differ between the vaccine and placebo.

Although meningococcal vaccines can have frequent mild side effects, they very rarely have serious side effects.

Not everything that happens during a clinical trial is related to the vaccine, even though it still gets reported. Another Menactra trial reported no deaths and the serious adverse events that were reported weren’t related to getting vaccinated.

Here is another meningococcal study in which a few of the participants died – one in a car accident and the other a drug overdose.

These deaths were not related to getting vaccinated, but were listed because they occurred during the study.
These deaths were not related to getting vaccinated, but were listed because they occurred during the study.

Unfortunately, vaccines can’t protect you from everything…

It would be especially nice if they could protect us from bad anti-vaccine memes.

More on Meningococcal Vaccine Safety

At What Age Should Kids Get a Meningococcal Vaccine?

Knowing when to give or get a vaccine doesn’t usually cause any confusion.

You simply have to check the immunization schedule.

Take the meningococcal vaccines, for example. Most parents and pediatricians understand that kids get them before entering middle school and again before going off to college. And some high risk kids should get them even earlier, as infants.

Simple, right?

At What Age Should Kids Get a Meningococcal Vaccine?

Actually, there are some things that make it a little more complicated than it should be…

Why?

  • some overnight and summer camps are actually starting to require a dose of meningococcal vaccine for younger kids, even though this is not a formal recommendation of the CDC or AAP
  • some parents might request a dose of meningococcal vaccine for younger kids going to overnight and summer camps, even though this is not a formal recommendation of the CDC or AAP
  • some folks are misunderstanding recommendations that campers be up-to-date on all immunizations as a recommendation that they get an early meningococcal vaccine
  • getting an early dose, before age 10 years won’t count as the middle school dose, and will need to be repeated
  • some states have very strict laws on timing, like that kids have to get their meningococcal vaccine before starting 6th grade, but only after they turn 11 years old, which creates a problem for those kids who start 6th grade before they are 11 years old
  • many folks don’t understand the recommendations for the MenB vaccines

What’s the answer?

It is not to skip or delay your child’s meningococcal vaccine, of course.

Older teens and young adults are at much higher risk of meningococcal disease than younger school age children.
Older teens and young adults are at much higher risk of meningococcal disease than younger school age children.

Instead, states should likely institute their meningococcal vaccine laws to require a dose before entering 7th grade, that way, most will have plenty of time to get it while they are in 6th grade. Or at least keep to the standard minimum age of 10 years for a dose to count towards middle school requirements.

What about a meningococcal vaccine for campers?

“In New York State, PHL Article 21, Title 6, Section 2167 also requires the notification of campers and parents about recommendations for and the availability of meningococcal vaccine for all campers attending overnight camps for a period of 7 or more consecutive nights. Meningococcal ACWY (MenACWY) vaccine is recommended at age 11 or 12 years, with a booster dose at age 16 years. Please note that the NYSDOH does not recommend that campers receive either dose of MenACWY vaccine before the recommended ages. Students who are vaccinated before the recommended ages may need to have the doses repeated in order to attend school.”

Recommended Immunizations for Campers

Unless they are in a high risk group, folks should likely stick to the standard ages of the immunization schedule to get their kids vaccinated.

And keep in mind that if your child does get an early dose, it won’t count as part of the routine series and will have to be repeated.

“Doses of quadrivalent meningococcal vaccine (either MPSV4 or MenACWY) given before 10 years of age should not be counted as part of the routine 2-dose series. If a child received a dose of either MPSV4 or MenACWY before age 10 years, they should receive a dose of MenACWY at 11 or 12 years and a booster dose at age 16 years.”

Ask the Experts Meningococcal ACWY

Talk to your pediatrician about an early dose if the extra coverage is important to you though. It will protect your child, but isn’t a general recommendation because younger kids have a lower risk for disease and vaccinating everyone likely wouldn’t impact disease rates that much.

Another situation in which getting an extra dose may be required is if you are traveling to a high risk part of the world. In this case, the extra dose is essential, even if it has to be repeated later.

More on Ages to Give Meningococcal Vaccines

Complications of Vaccine-Preventable Diseases

We know that vaccine-preventable diseases can be life-threatening.

In the pre-vaccine era, when these diseases were much more common, way too many people died, but still, most people did recover.

They didn’t always survive without complications though.

Tragically, we are starting to see more of these complications as more kids are now getting some of these vaccine-preventable diseases again.

Complications of Vaccine-Preventable Diseases

That we can prevent these serious complications is another benefit of getting vaccinated!

How serious?

Have you ever seen someone who has survived a meningococcal infection?

Do they always have all of their arms and legs?

How about their fingers and toes?

"Baby" Charlotte survived her battle with meningococcemia and continues to take on new challenges!
“Baby” Charlotte survived her battle with meningococcemia and continues to take on new challenges!

There is a reason that we say that you have to earn your natural immunity. You have to survive these diseases to get it. And you want to survive without any long-term complications, which can include:

  1. chicken pox – shingles, secondary bacterial infections, pneumonia, meningitis, encephalitis, seizures, transverse myelitis, Reye syndrome, neonatal varicella, congenital varicella syndrome
  2. congenital rubella syndrome – neonatal death, heart problems, deafness, cataracts, intellectual disability, liver and spleen damage, glaucoma, thyroid problems
  3. diphtheria – myocarditis, heart failure, nerve damage, muscle paralysis
  4. Haemophilus influenzae type b – meningitis, epiglottitis, pneumonia, osteomyelitis, cellulitis, hearing loss, brain damage, loss of limbs
  5. hepatitis A – can rarely lead to liver failure
  6. hepatitis B – chronic hepatitis B, cirrhosis, liver failure, liver cancer
  7. HPV – genital warts, cancer
  8. influenza – parotitis, pneumonia, myocarditis, encephalitis, myositis, rhabdomyolysis, multi-organ failure
  9. measles –pneumonia, seizures, encephalitis, SSPE
  10. mumps – orchitis (inflammation of the testicles), oophoritis (inflammation of the ovaries), pancreatitis, meningitis, encephalitis
  11. pneumococcal disease – pneumonia, mastoiditis, meningitis, bacteremia, sepsis, empyema, pericarditis, hearing loss, brain damage
  12. pertussis – pneumonia, seizures, apnea, encephalopathy, rib fractures
  13. polio – meningitis, paralysis, post-polio syndrome
  14. rabies – it is very rare to survive a rabies infection without treatment
  15. rotavirus – dehydration, intussusception
  16. rubella – arthritis, congenital rubella syndrome
  17. shingles – postherpetic neuralgia, pneumonia, hearing problems, blindness, encephalitis
  18. tetanus – seizures, laryngospasm, fractures, pulmonary embolism, aspiration pneumonia
  19. typhoid fever – intestinal perforation, internal bleeding, peritonitis, hepatitis, osteomyelitis, arthritis, meningitis, myocarditis,
  20. yellow fever – pneumonia, parotitis, sepsis

Anti-vaccine folks rarely talk about the complications of vaccine-preventable diseases. For that matter, they also often push the idea that vaccines don’t even work and that these diseases aren’t even vaccine preventable, don’t they?

Don’t believe them. Vaccines work and they are safe and necessary, especially if you want to avoid these diseases.

More on Complications of Vaccine-Preventable Diseases

Is Meningitis a Side Effect of Vaccines?

Most folks know that there are several meningitis vaccines.

Hib, Prevnar, MMR, and the meningococcal vaccines, for example, all protect folks against meningitis.

Is Meningitis a Side Effect of Vaccines?

So why would some people think that vaccines could actually cause meningitis?

Is meningitis listed on the package insert of any vaccines?
Is meningitis listed on the package insert of any vaccines?

Meningitis is listed as a possible adverse event in the package insert of some vaccines, but only in the section that includes spontaneously reported data from post-marketing experience, where it “may not be possible to reliably estimate their frequency or establish a causal relationship to vaccine exposure.”

It is just like when folks find autism or SIDS in a vaccine’s package insert and think that it is evidence that vaccines are associated with autism or SIDS.

SIDS and autism are listed in Tripedia package insert, but are not causally linked to the vaccine.
SIDS and autism are listed in Tripedia package insert, but are not causally linked to the vaccine.

It isn’t.

These adverse reactions are listed “because of the seriousness OR frequency of reporting.” They are not included because they are serious AND frequent, as some anti-vaccine sites like to proclaim.

How Could a Vaccine Cause Meningitis?

When you think about it, how could a vaccine actually cause someone to develop meningitis?

Why would you even think this is true?

Meningitis is typically caused by a virus, bacteria, parasite, or fungus, etc.

While a live virus vaccine might rarely be able to cause an infection, few of the meningitis vaccines are live virus vaccines. Prevnar, Hib and the meningococcal vaccines are all sub-unit vaccines. Since only a part of bacteria (antigens) is actually present in the vaccine, it is not possible for them to cause an infection.

What about the live virus vaccines, like MMR, chicken pox, and rotavirus?

Since these viral infections rarely cause meningitis, except for mumps, you wouldn’t expect the rare vaccine induced infection to cause meningitis either. A natural measles infection, for example, is more likely to cause encephalitis instead.

“…there is no evidence to link Jeryl Lynn mumps vaccine to aseptic meningitis.”

MMR Package Insert

What about the chicken pox vaccine? There is a case report of a vaccinated child who later developed shingles and meningitis, caused by vaccine strain chicken pox virus. He recovered fully and it is important to note that folks with natural chicken pox are thought to be even more likely to develop shingles, and they too can develop meningitis.

The bottom line is that if someone has meningitis, even if they were recently vaccinated, you shouldn’t be blaming the vaccines.

Like they do with VAERS reports, misusing package inserts is a common method that anti-vaccine folks use to scare parents away from vaccinating and protecting their kids.

What to Know About Meningitis and Vaccine Package Inserts

Although included in some vaccine package inserts, except for rare circumstances with some live virus vaccines, none actually claim that vaccines cause meningitis.

More on Meningitis and Vaccine Package Inserts

How the Anti-Vaccine Movement Takes Advantage of Dead Children and Their Parents

It is bad enough that folks in the anti-vaccine movement use propaganda to scare parents away from vaccinating and protecting their kids.

“The anti-vaccine argument is wrong in both the scientific and moral sense.”
Sarah Kurchak on Here’s How the Anti-Vaccination Movement Hurts Autistic People

Many people also think that the anti-vaccine message is anti-autism.

How the Anti-Vaccine Movement Takes Advantage of Dead Children and Their Parents

But just when you thought that they couldn’t go any lower, folks in the anti-vaccine movement find new ways to demonstrate their lacks of morals.

As a physician, I assure you this story isn’t believable at any level. In my opinion, the “health officials” are conjuring meningitis fairy tales about an “unvaccinated” boogeyman to cover for the much more probable cause of this child’s death: VACCINES.

The much more likely cause is right in front of us: “The child had just received his 4-month-old vaccinations two days beforehand.”

Jim Meehan

What is Dr. Jim Meehan talking about?

A four-month-old who recently died of bacterial meningitis in Chesterfield County, Virginia.

“Notice that THREE of the vaccines given at 4 months are for organisms capable of invading the brain and causing MENINGITIS. Rotavirus is a live virus vaccine capable of shedding from recently vaccinated children. The vaccine pre-clinical trials lacked placebo controls and were associated with infant deaths.

It doesn’t take my medical degree to understand how flimsy are the claims in this story.”

Jim Meehan

While rotavirus is a live virus vaccine, rotavirus rarely causes central nervous system disease. And he died of bacterial meningitis. It shouldn’t take a medical degree to know that rotavirus is a virus, not a bacteria.

While two of the other vaccines routinely given at four months do actually protect you from meningitis, both Prevnar and Hib are sub-unit vaccines, so can’t actually cause disease. Unfortunately, at four months, he would have been only partially protected against Prevnar and Hib, having only received two of four dosages of those vaccines.

“They expect the general public to be ignorant of the fact that we can actually measure the presence of the meningitis causing organisms for which there are vaccines: Haemophilus influenzae, Pneumococcus, and Meningococcus. So, where are the tests that confirm the presence of one of these “vaccine preventable” organisms?! Where’s the spinal tap/CSF pathology report?

As hard as it is for a grieving family to conceive of an autopsy, I pray the family demands a confirmation of the farcical cause of death being contrived in this case.”

Jim Meehan

Has Jim Meehan heard of HIPAA?

Does he read any of the other messages when he is writing his own comments about this family?

Why should this family have to come out and give an explanation for how their child died?
Why should this family have to come out and give an explanation for how their child died?

Is Jim Meehan really a doctor? It shouldn’t take a medical degree to understand that carriers of a disease don’t usually have symptoms of the disease.

“Again, from the article: “Health care officials told Dempsey they BELIEVE an unvaccinated person was carrying meningitis and Killy happened to come into contact with that person.”

They “believe”…give me a break. It should have said, “they made-up a story to cover for the real cause.”

SECOND, people don’t walk around with meningitis. They lay in their beds in a dark room and writhe in pain.

THIRD, the likelihood that an unvaccinated individual was walking around with meningitis is vanishingly small. To even list that in the top 100 options of a differential diagnosis is pure fiction.

FOURTH, where is this hypothetical unvaccinated meningitis shedding “patient zero?” He or she would have been so obviously sick that there is no way new parents would not remember the likely suspect…unless the suspect never existed.”

Jim Meehan

In this case, with a meningococcal infection, which is what the infant is thought to have, about 10% of people are carriers, asymptomatically having the Neisseria meningitidis bacteria in their nose or throat.

In the United States, we have two types of meningococcal vaccines, neither of which is routinely given to infants:

  • Menactra and Menveo – meningococcal conjugate vaccines that protect against serogroups A, C, W, Y and first given when kids are 11 to 12 years old, with a booster at age 16 years.
  • Bexsero and Trumenba – meningococcal conjugate vaccines that only  protect against serogroup B and can be given to kids at increased risk and teens and young adults who want to reduce their risk of getting MenB disease

The only other possibility, since they mentioned that exposed people received antibiotics, would be the Hib bacteria.

“In the prevaccine era, Hib could be isolated from the nasopharynx of 0.5%–3% of normal infants and children but was not common in adults.”

CDC on the Epidemiology and Prevention of Vaccine-Preventable Diseases

Again, these carriers can be contagious, even though they don’t have any symptoms.

“It’s likely that these “health officials” are covering for the pharmaceutical/vaccine industry that pays them so well. It’s “health officials” like this that for decades have pretended that sudden unexplained infant death syndrome (SUIDS), not only has no explanation, but it couldn’t possibly be related to the injection of neurotoxic doses of aluminum into the bodies of tiny baby humans. They can ignore the clustering of infant deaths that occurs around the same times that CDC recommends multiple (5-13) vaccines at one visit, but I won’t.”

Jim Meehan

Why is a family that just lost their child getting harassed by anti-vaccine folks?

This is the modern anti-vaccine movement.
This is the modern anti-vaccine movement.

One clue is that Jim Meehan is pushing the idea that there is a Big Pharma conspiracy behind this child’s death.

An anti-vaccine parenting group helping spread misinformation about this baby's death.
An anti-vaccine parenting group helping spread misinformation about this baby’s death.

And there are many anti-vaccine parenting groups that are helping spread his message around.

Of course, this isn’t the first time this has happened.

Anti-vaccine folks routinely hound parents who die of SIDS and shaken baby syndrome, working to convince them that vaccines caused their deaths.

Even infants who die of vitamin K deficiency bleeding because they skipped their baby’s vitamin K shot all of a sudden have a vaccine injury.

They turn every story of a child’s death or disability into a vaccine injury story.

Shame on them all.

More on the Vultures of the Anti-Vaccine Movement