Tag: placebos

What’s the Difference Between the MMR and MMR-II Vaccines?

As most folks know, the original MMR vaccine, which combined the separate measles, mumps, and rubella shots, was licensed way back in 1971.

It included the original rubella vaccine, which was made with a duck embryo derivative of HPV-77 that was attenuated by passing it 77 times in monkey kidney cells.

Wait, what?

HPV?

Before the new conspiracy theories start, no, not that HPV.

It stands for High Passage Virus.

What’s the Difference Between the MMR and MMR-II Vaccines?

And while the vaccine worked, it didn’t work as well and caused more side effects than a RA27/3 rubella vaccine that was already approved in Europe

“Over the next decade, accumulating evidence led to changes in the United States. First, the duck embryo and dog kidney vaccine strains caused significant joint reactions [24–27]. Second, reinfection on exposure to wild rubella virus was demonstrated frequently with all strains except the RA 27/3 vaccine [28–30]. Third, the good safety record of the RA 27/3 vaccine in Europe, plus the majority opinion of scientists, led the US Food and Drug Administration to license RA 27/3. Important pressure for this decision came from Dorothy Horstmann at Yale, who was convinced by her comparative studies of rubella vaccines [31], and by Maurice Hilleman at Merck, who sought a better rubella strain for measles-mumps-rubella (MMR) vaccine.”

Stanley Plotkin on The History of Rubella and Rubella Vaccination Leading to Elimination

So that’s it, they just changed out the rubella component for one that was safer and worked better.

The new and improved MMR-II vaccine was approved by the FDA in 1978.
The new and improved MMR-II vaccine was approved by the FDA in 1978.

And of course, they did the appropriate clinical trials and got FDA approval for this updated vaccine.

The control group didn't get a vaccine during the study.
The control group didn’t get a vaccine during the study.

But did they compare the vaccines against a saline placebo?

“The inclusion of a seropositive control group allowed the rates of reaction to be viewed against the background symptoms unrelated to vaccine administration.”

Polk et al on A controlled comparison of joint reactions among women receiving one of two rubella vaccines.

They actually went a little further, in a double-blind, controlled cohort study comparing it to folks who didn’t receive any vaccine at the time of the study!

Why so many joint issues with the vaccine?

The studies were in adults, who seemed to have more side effects with the vaccine. Still, the side effects, including arthritis, were transient.

What about the idea that it was studied long enough before being approved?

Both the rubella component and the MMR-II vaccine were studied both before and after being approved. In fact, the MMR-II vaccine is probably the most studied vaccine in history!

Believe it or not, they include placebo-controlled trials.

A double-blind, placebo-controlled, cross-over MMR study in twins!

What was the placebo in the Finland twin trial?

“The injections consisted of 0.5 ml of vaccine 2-5 or placebo (the same product including neomycin and phenol-red indicator but without the viral antigens) and were administered subcutaneously by the nurse to the left deltoid or gluteal region.”

Peltola et al on Frequency of true adverse reactions to measles-mumps-rubella vaccine. A double-blind placebo-controlled trial in twins.

If that doesn’t sound like a placebo to you, keep in mind that the MMR vaccine doesn’t contain that many ingredients. Remember, MMR doesn’t contain aluminum or thimerosal. And if the placebo didn’t contain the antigens, then it likely didn’t contain all of the things that went into getting those antigens in the vaccine, such as cell cultures and albumin, etc.

Still, some folks aren’t going to be satisfied unless there is a study with a saline placebo.

“The four other vaccines were commercial products of Merck Sharp & Dohme. The placebo consisted of vaccine diluent.”

Lerman et al on Clinical and Serologic Evaluation of Measles, Mumps, and Rubella (HPV-77: DE-5 and RA 27/3) Virus Vaccines, Singly and in Combination

The vaccine diluent?

What’s that?

It depends on the vaccine, but for MMR-II it’s sterile water.

“Placebo DTP consisted of sterile saline which was dispensed into sterile Tubex syringes.”

Deforest et al on Simultaneous Administration of Measles-Mumps-Rubella Vaccine With Booster Doses of Diphtheria-Tetanus-Pertussis and Poliovirus Vaccines

The MMR vaccine was even tested in placebo controlled trials with other vaccines!

And like other vaccines, the MMR vaccine has been found to be safe, with few risks, and is definitely necessary.

More on the the Difference Between the MMR and MMR-II Vaccines

Kennedy Has a Fundraiser in the Middle of the Largest and Longest Measles Outbreak in Recent New York History

Remember when Andrew Wakefield went to Minnesota during their large measles outbreak?

It’s reminiscent of the NRA holding one of their conventions in a city after a big shooting, isn’t it?

Kennedy Has a Fundraiser in the Middle of the Largest and Longest Measles Outbreak in Recent New York History

While it seemed like a big outbreak at the time, those 13 cases would actually be considered rather small these days. In fact, a more recent outbreak in Minnesota, in 2017, had at least 79 cases!

And not surprisingly, anti-vaccine folks also visited the state to try and keep that outbreak going!

Do these folks ever learn?

Flash forward to 2019…

Since September of 2018, New York has seen over 332 cases of measles in two big outbreaks in Brooklyn and Rockland County.

So where does Robert F. Kennedy, Jr. choose to go for a fundraiser?

Where does he show up on TV to push his message about vaccine dangers?

Yup, New York City.

Lori Stokes: “Can I switch gears for a minute and talk about vaccines…”

Kennedy: “When I was a kid, we got three vaccines. That I took. My kids got 64 mandated vaccines.”

Rosanna Scotto: “How many? 64?”

Kennedy: “64”

Rosanna Scotto: “Wow!”

Kennedy: “Mandated doses. Today’s kids get 72, by the end of next year it will be 75. It’s all driven by profit. Most of these diseases are illnesses that you don’t need to be vaccinated for. “

Fox 5 Good Day New York

Wow indeed. That sounds like a lot because kids typically only get 13 vaccines that protect them against 16 vaccine-preventable diseases. We don’t even have 64 vaccines!

You only get to a number like 64 or 72 or 75 if you inflate the count to make it sound scarier.

In reality, if you count a yearly flu vaccine, kids get about 54 doses of vaccines through age 18.

Are any for diseases that you don’t need to be vaccinated for?

Which disease do you want your kids to get?

Do you want them to get tetanus, meningitis, epiglottitis, diphtheria, meningococcemia, cancer (hepatitis B and HPV infections) or to have grandchildren with congenital rubella syndrome?

Vaccines are safe, with few risks, and are necessary.

Ask yourself why folks like this are still allowed to push this kind of misinformation on folks, especially in the middle of an outbreak.

More on Kennedy’s Fundraisers

Can You Prove That Jamie McGuire Books Don’t Make Teens Do Drugs?

Apparently, Jamie McGuire is a best-selling author.

According to Yahoo Lifestyle, she is the “author of 20 books in the New Adult genre (for ages 18-30), including Walking Disaster — which debuted at No. 1 on the New York Times, USA Today and Wall Street Journal bestseller lists — as well as the apocalyptic thriller Red Hill.”

And she wants everyone to know that she does not consent!

Can You Prove That Jamie McGuire Books Don’t Make Teens Do Drugs?

What does Jamie McGuire not consent to?

Since her whole post is about proving this and that about vaccines, which she seems to think are bad, I am guessing that she does not consent to getting vaccinated or to vaccinating her kids.

The thing is though, no one is trying to force her to vaccinate her kids.

You can just say that you don’t want to vaccinate your kids, coming out as another anti-vaccine pseudo-celebrity, without hijacking “I do not consent” messaging.

Anyway, her concerns about vaccines have been addressed. Indeed, they have been talked about a million times. If she were truly aware, she would stop being misled by anti-vaccine arguments that scare parents away from thinking that vaccines are safe, with few risks, and necessary.

Do we have proof? We have evidence!

And as the title says, can you prove that her books don’t make teens do drugs?

More on Jame McGuire and Consent

Where are the Saline Placebos?

Remember when anti-vaccine folks used to say that there were no double-blind, placebo-controlled randomized clinical trials for vaccines?

What happened once they realized that there actually were?

They moved the goal posts…

Where are the Saline Placebos?

Okay, they said.

So you have done double-blind, placebo-controlled randomized clinical trials when testing vaccines, but what placebo did you use?

Was it a pure saline placebo?

“Placebo Control – A comparator in a vaccine trial that does not include the antigen under study. In studies of monovalent vaccines this may be an inert placebo (e.g. saline solution or the vehicle of the vaccine), or an antigenically different vaccine. In combined vaccines, this may be a control arm in which the component of the vaccine being studied is lacking.”

WHO on the Guidelines on clinical evaluation of vaccines: regulatory expectations

Although no guidelines actually call for using a pure saline placebo, that’s all anti-vaccine folks will accept these days.

Why?

That’s their MO – or method of operation.

When one theory or myth gets squashed – they move to another.

They move the goalposts.

It doesn’t matter that there are often ethical and logistical problems with using pure saline placebos, that’s all they want to hear about it.

That they wouldn’t be satisfied and start vaccinating their kids if all vaccine studies started to use saline placebos should be evident when you consider that many vaccine studies have already used saline placebos!

There are many more vaccine studies that have used saline placebos and like other vaccine studies, have found vaccines to be safe and effective.

But how do you know that they used a real saline placebo and not some kind of saline solution with other stuff in it?

If it isn’t clear to you in the methods section of the study, go to the source – the original clinical trials record and it will be listed there.

What are you going to be worried about now?

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