Tag: saline placebo

What Are the Demands and Goals of the Anti-Vaccine Movement?

So what exactly do anti-vaccine folks want?

What are they trying to do?

Are they trying to scare parents away from getting vaccinating and protecting their kids, hoping to drag us back to the pre-vaccine era?

What Are the Demands and Goals of the Anti-Vaccine Movement?

Of course, some of the folks who are anti-vaccine don’t actually like to be called anti-vaccine. Instead, they prefer to say that they are pro-safe vaccines. So for them, it is rather obvious – they want safer vaccines without toxins.

Now, since vaccines are already safe and don’t contain any toxic ingredients, it would seem like their work is done already, right?

Another goal is having fewer vaccines on the immunization schedule. Jenny McCarthy often pushes the Turn Back the Clock immunization plan, wanting kids to only get vaccines that were on the 1983 immunization schedule, back when kids still died of meningitis, pneumonia, blood infections, severe dehydration, epiglottitis, and cancer from Hib, pneumococcal disease, rotavirus, hepatitis B, hepatitis A, chicken pox, HPV, and meningococcal disease, which are now vaccine preventable.

Other members of the anti-vaccine movement talk about vaccine choice. They want to be able to choose whether or not they should have to vaccinate their kids.

Again, done. No one is forcing parents to vaccinate their kids. We may not have a choice on whether or not your unvaccinated child gets sick and puts someone else at risk for getting a vaccine-preventable disease because they were too young to be vaccinated, had a medical exemption, or their vaccine didn’t work, but you can certainly make the choice to skip or delay any vaccines you want.

“I also warn them not to share their fears with their neighbors, because if too many people avoid the MMR, we’ll likely see the diseases increase significantly.”

Dr. Bob Sears in The Vaccine Book

What are other goals of the anti-vaccine movement?

Johns Hopkins Medicine, which includes the Johns Hopkins University School of Medicine and the The Johns Hopkins Hospital and Health System went out of their way to correct this anti-vaccine misinformation.
Johns Hopkins Medicine went out of their way to correct this anti-vaccine misinformation about shedding.

Have you heard about the anti-vaccine folks who want to quarantine all kids who have recently been vaccinated for at least six weeks? Why quarantine kids who have been vaccinated? They are worried about shedding

Would anyone go so far as wanting to ban vaccinations? Yup. So much for vaccine choice.

Some others want to rescind the 1986 National Childhood Vaccine Injury Act, which they think will help make it easier to sue vaccine manufacturers. That’s one of Andrew Wakefield‘s demands in his movie VAXXED. He and others never mention that if you are suing in civil court, then you must meet a higher burden of proof for vaccine injury than you do in Vaccine Court.

Remember when Robert F. Kennedy, Jr. thought he would be appointed to some special Trump commission on vaccines?

“We want safe vaccines, robust transparent science and an honest and independent regulatory agency focused narrowly on public health rather than industry profit.”

Robert F. Kennedy, Jr. on Mercury, Vaccines and the CDC’s Worst Nightmare

Kennedy’s vaccine commission never happened, but that hasn’t stopped him from pushing for an independent regulatory agency.

I’m not sure who would run or be a part of Kennedy’s independent regulatory agency though, as he believes that “Congress, the regulatory agencies, FDA and CDC, the IOM, the NIH, the AAP, the science journals, the university science departments and the press” have all been compromised by Pharma.

Kennedy also wants thimerosal out of vaccines, which, as most people know, is already out of all vaccines on the immunization schedule, including about 100 million doses of flu shots this past year. But like others, he seems to be moving on to aluminum as his new target.

What else?

Fortunately, it is easy to see why the demands and goals of the modern anti-vaccine movement are dangerous, unethical, and unnecessary, and like parents who decide to skip or delay vaccines, will simply put us all at risk for more outbreaks of vaccine-preventable disease.

What to Know About the Demands and Goals of the Anti-Vaccine Movement

Whatever their demands and goals of the anti-vaccine movement, the effect is that they are scaring parents away from vaccinating and protecting their kids from life-threatening vaccine-preventable diseases for no good reason.

More on the Demands and Goals of the Anti-Vaccine Movement

Where are the Double Blind Placebo Controlled Randomized Trials about Vaccines

Have you ever heard that there are no double-blind, placebo-controlled randomized clinical trials for vaccines?

It isn’t true.

There are many double-blind, placebo-controlled randomized clinical trials that involved:

  • flu shots
  • pneumonia shots
  • HPV vaccines
  • potential HIV vaccines
  • malaria vaccines
  • rotavirus vaccines
  • Dengue vaccine
  • Staphylococcus aureus vaccine

That’s good, because double-blind, placebo-controlled randomized clinical trials are considered the “gold standard” when you do medical research.

“Placebo Control – A comparator in a vaccine trial that does not include the antigen under study. In studies of monovalent vaccines this may be an inert placebo (e.g. saline solution or the vehicle of the vaccine), or an antigenically different vaccine. In combined vaccines, this may be a control arm in which the component of the vaccine being studied is lacking.”

WHO on the Guidelines on clinical evaluation of vaccines: regulatory expectations

Tragically, many more folks got pneumonia and died if they got the saline placebo instead of the vaccine in this study.
Tragically, many more folks got pneumonia and died if they got the saline placebo instead of the vaccine in this study.

But do they all use a saline placebo?

No, not always, which typically leads anti-vaccine types to dismiss them outright and push anti-vaccine misinformation, including that they are never done.

It seems that they aren’t worried so much about the antigens in vaccines anymore (the Too Many, Too Soon argument), but are now more concerned about other vaccine ingredients. They will only be satisfied with a saline placebo, but they must miss the part about wanting the trial to be double-blinded, which gets harder to do if the placebo doesn’t look and “feel” like the vaccine.

And they miss the part that “not always” doesn’t mean never.

Gardasil is a good, recent example of a vaccine that had a double-blind, placebo-controlled (using a saline solution without an adjuvant) trial for safety.

Others vaccine trials use a saline control too, including efficacy and safety trials for a new recombinant, live, attenuated, tetravalent dengue vaccine (it worked and had a good safety profile), a malaria vaccine (a phase I dose escalation study), a universal flu vaccine, a Staphylococcus aureus vaccine, etc.

The Ethics of Placebo Use in Vaccine Trials

So why haven’t placebo control studies been done even more routinely then?

Why isn’t every vaccine on the immunization schedule or every combination of vaccines tested using a double-blind, placebo controlled study?

“Placebo use in vaccine trials is clearly acceptable when (a) no efficacious and safe vaccine exists and (b) the vaccine under consideration is intended to benefit the population in which the vaccine is to be tested.”

Placebo use in vaccine trials: Recommendations of a WHO expert panel

Of course, the answer is that in order to do this type of study, you would have to have a very good justification for leaving many of the kids unprotected and at risk for a vaccine-preventable disease.

Instead, as is discussed in the article “Current topics in research ethics in vaccine studies,” if a vaccine is “already in use in some other country or community which is more or less comparable to site where the trial is planned, that vaccine should be used as the comparator.”

So instead of a placebo, it is more common “to give another vaccine that provides comparable benefit against another disease, or more willingly, against similar disease caused by different agents.”

When can you use a placebo control?

The article states that “placebo controls are ethically acceptable when there is no proven vaccine for the indication for which the candidate vaccine is to be tested.”

But get educated and don’t be fooled, many double-blind, placebo-controlled randomized clinical trials have been done with vaccines.

What to Know About Placebo Use in Vaccine Trials

When it is ethical to do so, placebos have been used in vaccine trials, even saline placebos.

More on Placebo Use in Vaccine Trials