Tag: GBS

More Vaccinated vs Unvaccinated Studies

Anti-vaccine folks continue to call for vaccinated vs unvaccinated studies.

A vaccinated vs unvaccinated study that anti-vaccine folks don't talk about...
A vaccinated vs unvaccinated study that anti-vaccine folks don’t talk about…

Not surprisingly, they ignore all of the studies that have already been done.

More Vaccinated vs Unvaccinated Studies

Listening to these anti-vaccine folks, you would actually think that the only vaccinated vs unvaccinated “study” that has ever been done is the survey about homeschoolers that they always talk about

That leaves out a lot of other vaccinated vs unvaccinated studies, including:

Do we need even more studies on vaccinated vs unvaccinated children?

We already know that unvaccinated kids get sick more and they have more severe disease. Who is going to approve of or want to do a study that only puts kids at risk to get a vaccine-preventable disease?

Vaccines are safe, with few risks, and they are obviously necessary.

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ACIP June 2019 Update

The Advisory Committee on Immunization Practices (ACIP) holds three meetings each year at the Centers for Disease Control and Prevention (CDC) in Atlanta, Georgia to review scientific data and vote on vaccine recommendations.

Topics at the ACIP June 2019 meeting, held on June 26 and 27, included:

  • 9vHPV Immunogenicity and Safety Trial in Mid-Adult Females
  • Overview of Health Economic Models for HPV Vaccination of Mid-Adults
  • HPV Vaccines Evidence to Recommendations (EtR) Framework
  • HPV Vaccines Work Group Considerations and Proposed Policy Options
  • Considerations for PCV13 use among adults 65 years or older and summary of the Evidence to Recommendations (EtR) Framework Proposed policy options
  • Combination Vaccines – Summary and Relevant Evidence to Recommendation Information
  • Update: Safety Monitoring and Surveillance for Recombinant Zoster Vaccine (RZV)
  • Herpes Zoster Work Group Summary
  • Pertussis Vaccines EtR Framework, Work Group Considerations and Proposed Policy Options
  • Rabies Vaccine
  • 2018-19 U.S. Influenza Activity
  • 2018-19 Influenza Vaccine Effectiveness
  • 2018-19 Influenza Vaccine Safety
  • Influenza Vaccine Proposed Recommendations for 2019-20
  • Proposed Recommendations for Use of Hepatitis A
  • Dengue Epidemiology in the U.S.
  • Dengvaxia Phase III Clinical Trials and Long Term Follow Up
  • Dengue Vaccine Work Group Considerations and Next Steps

If you haven’t been watching the meeting, the slides, videos, and minutes will be available later.

ACIP June 2019 Meeting Votes

And ACIP members voted on a number of issues, including:

Passed.
Passed.
This changes the 2014 ACIP recommendation to give PCV13 to all adults 65 years or older.
A series of votes on DTaP, Hib, IPV, and hepB got Vaxelis, the newly FDA approved hexavalent vaccine, added to the VFC program.

Coming up tomorrow will be votes on flu, hepatitis A, and meningococcal B vaccines.

More on the ACIP June 2019 Meeting

Is AFM a Form of Transverse Myelitis?

Acute Flaccid Myelitis (AFM) is a form of acute flaccid paralysis.

“AFM can be difficult to diagnose because it shares many of the same symptoms as other neurologic diseases, like transverse myelitis and Guillain-Barre syndrome. With the help of testing and examinations, doctors can distinguish between AFM and other neurologic conditions.”

About Acute Flaccid Myelitis

AFM is not transverse myelitis, Guillain-Barre syndrome (GBS), or Acute Disseminated Encephalomyelitis (ADEM) though, although anti-vaccine folks are trying hard to make a connection.

Is AFM a Form of Transverse Myelitis?

AFM is similar to transverse myelitis, in that they both affect a person’s spinal cord, but a big difference is that TM results from “an immune-mediated inflammatory attack of a person’s spinal cord.”

“This report and others indicate that AFM represents a unique subset of acute flaccid paralysis distinct from GBS and transverse myelitis. GBS typically presents with an ascending paralysis and can be associated with facial paralysis and sensory symptoms. Children with transverse myelitis have weakness and prominent sensory loss, often manifest as a spinal sensory level. By contrast, the majority of children with AFM have focal, poliomyelitis-like spinal cord paralysis with minimal or no sensory symptoms.”

Recognition and Management of Acute Flaccid Myelitis in Children

And AFM has different symptoms from both TM and GBS.

So why try to connect AFM with TM, GBS, and ADEM? Because they think that vaccines cause TM, GBS, and ADEM.

They don’t. Just like vaccines don’t cause AFM.

There is no proof in package inserts that vaccines cause AFM.
There is no proof in package inserts that vaccines cause AFM.

But can’t you find some of these things listed in the package insert for some vaccines?

Yes, but when mentioned in a vaccine’s package insert, like for autism, SIDS, or meningitis, it is in the section where it is clear that it is “without regard to causality.”

AFM is not transverse myelitis and neither are caused by vaccines.

We will hopefully learn what is causing the latest cases of AFM soon.

More on AFM and Transverse Myelitis

Who is Alexander Langmuir?

Alexander Langmuir is typically described as a hero or titan of public health.

Then why do some folks think he was against the flu and measles vaccines?

Who is Alexander Langmuir?

Dr. Alexander Langmuir has been called the father of infectious disease epidemiology.

Why?

In 1949, he established the CDC’s Epidemiology Program. Actually, at the time, the CDC was still called the Communicable Disease Center.

Dr. Alexander Langmuir and his Polio Surveillance Unit at the EIS in 1955.
Dr. Alexander Langmuir and his Polio Surveillance Unit at the EIS in 1955.

Dr. Langmuir, as Chief Epidemiologist at CDC for 21 years, also:

  • founded the Epidemic Intelligence Service (EIS)
  • instituted a malaria surveillance system
  • established national disease surveillance system for the United States
  • was involved in resolving the Cutter incident
  • brought the Morbidity and Mortality Weekly Report to CDC
  • investigated the swine influenza virus vaccine incident, when it was thought that some people developed GBS after getting the new swine flu vaccine in 1976

His work saved the lives of hundreds of thousands of people.

Don't believe any propaganda or quotes without sources attributed to Alexander Langmuir.
Don’t believe any propaganda or quotes without sources attributed to Dr. Alexander Langmuir.

Did he ever tell folks to not get a flu shot?

Was he ever concerned about mercury in flu shots?

Considering that Dr. Langmuir died in 1993, before folks became concerned about thimerosal in vaccines, that’s unlikely. That’s especially so considering that the only place you can find these types of quotes are on anti-vaccine websites.

Still, Langmuir was critical of flu shots.

“From this appraisal of the experience in the past three and one-half years, it is apparent that progress in the control of influenza has not been impressive.”

Langmuir et al. on The Epidemiological Basis For The Control Of Influenza

He didn’t think that they worked well enough. Or more importantly, he didn’t think we had enough information about how well they worked.

“Our information regarding the occurrence of influenza is largely qualitative. Schools close, absenteeism increases, medical services become taxed, virus isolations and serological identifications are made in great numbers, and daily accounts appear in our newspapers and on television. We know we have an epidemic and we know its specific cause, but we have few quantitative measures of incidence, age- and sex-specific attack rates, and character and severity of complications. Further- more, we have only crude data regarding mortality. We do not know what proportion of excess deaths occurs among reasonably active and productive citizens in contrast to deaths among persons who are already invalids suffering from severely debilitating pre-existing disease. Despite this serious deficiency we base our recommendations for vaccine use largely on mortality experience. We undertake major efforts to produce influenza vaccine in large amounts, but we have no meaningful information regarding its actual distribution. We do not know to what extent it actually reaches persons at highest risk.”

Langmuir et al. on A Critical Evaluation of Influenza Surveillance

But he wasn’t anti-vaccine.

And he never said that flu shots weren’t safe.

“The availability of potent and effective measles vaccines, which have been tested extensively over the past 4 years, provides the basis for the eradication of measles in any community that will raise its immune thresholds to readily attainable levels.”

Langmuir et al. on Epidemiologic Basis For Eradication Of Measles In 1967

And concerning all that he did in the field of public health, he is certainly not someone that anti-vaccine folks should be quoting.

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