More Vaccinated vs Unvaccinated Studies

Anti-vaccine folks continue to call for vaccinated vs unvaccinated studies.

Not surprisingly, they ignore all of the studies that have already been done.

More Vaccinated vs Unvaccinated Studies

Listening to these anti-vaccine folks, you would actually think that the only vaccinated vs unvaccinated “study” that has ever been done is the survey about homeschoolers that they always talk about…

That leaves out a lot of other vaccinated vs unvaccinated studies, including:

• Vaccination Status and Health in Children and Adolescents. Findings of the German Health Interview and Examination Survey for Children and Adolescents (KiGGS) – unvaccinated kids just got more vaccinated preventable diseases
• Vaccinated versus unvaccinated children: how they fare in first five years of life – again, unvaccinated kids just got more vaccine-preventable diseases
• No effect of MMR withdrawal on the incidence of autism: a total population study – the cumulative incidence of autism up to age seven increased significantly in the birth cohorts of years 1988 through 1996 and most notably rose dramatically beginning with the birth cohort of 1993, even though they had stopped using the MMR vaccine in early 1993.
• A population-based study of measles, mumps, and rubella vaccination and autism – looked at the relative risk of autistic disorder in a group of vaccinated children, as compared with an unvaccinated group, and found no association with the MMR vaccine.
• Early-life determinants of asthma from birth to age 20 years: a German birth cohort study – asthma incidence was lower in participants who were vaccinated
• Lack of broad functional differences in immunity in fully vaccinated vs. unvaccinated children – more evidence that vaccines don’t overwhelm a child’s immune system – innate and adaptive immune responses were not reduced, delayed, or altered in vaccinated vs unvaccinated kids
• Reduced Severity of Pertussis in Persons With Age-Appropriate Pertussis Vaccination-United States, 2010-2012 – kids who got pertussis had less severe disease than those who were unvaccinated
• Parental refusal of pertussis vaccination is associated with an increased risk of pertussis infection in children – unvaccinated kids got more pertussis
• Protective effect of vaccination against mumps complications, Czech Republic, 2007-2012 – vaccinated kids had fewer mumps complications than those who were unvaccinated
• Influenza vaccination is associated with reduced severity of community-acquired pneumonia – folks who got a flu vaccine had less severe course of community acquired pneumonia and improved survival than those who didn’t
• Cumulative risk of Guillain-Barré syndrome among vaccinated and unvaccinated populations during the 2009 H1N1 influenza pandemic – vaccinated people had less GBS
• Effect of human papillomavirus vaccination on cervical cancer screening in Alberta – vaccinated women were more likely to have cervical cancer screening and less likely to have high-grade cervical abnormalities
• Rates and determinants of seasonal influenza vaccination in pregnancy and association with neonatal outcomes – vaccinated women had lower rates of pre-term birth and low birth weight infants
• Rotavirus Vaccination and the Risk of Celiac Disease or Type 1 Diabetes in Finnish Children at Early Life – did unvaccinated kids get more Celiac disease or diabetes? No, no they didn’t.
• Does Measles Vaccination Reduce the Risk of Acute Respiratory Infection (ARI) and Diarrhea in Children: A Multi-Country Study? – getting a measles vaccine was associated with decrease in acute respiratory infections and diarrhea in vaccinated children
• Quadrivalent HPV vaccination and risk of multiple sclerosis and other demyelinating diseases of the central nervous system – HPV vaccination was not associated with the development of multiple sclerosis or other demyelinating diseases in vaccinated vs unvaccinated study participants
• Examining a possible association between human papilloma virus (HPV) vaccination and migraine: results of a cohort study in the Netherlands – Incidence rate ratios (IRRs) for vaccinated compared to unvaccinated girls were not statistically significantly higher.
• No evidence found for an increased risk of long-term fatigue following human papillomavirus vaccination of adolescent girls – No statistically significant increased incidence rates were found post-vaccination compared to similar age groups of girls pre-vaccination.
• Pertussis Immunisation in Pregnancy Safety (PIPS) Study: A retrospective cohort study of safety outcomes in pregnant women vaccinated with Tdap vaccine – compared to unvaccinated pregnant women, Tdap in pregnancy did not increase preterm labour, pre-eclampsia, or gestational diabetes mellitus and actually had a protective effect on pre-eclampsia with severe features, preterm labour, preterm delivery, and antenatal bleeding!
• Risk of chronic arthropathy among women after rubella vaccination. Vaccine Safety Datalink Team. – found no evidence of any increased risk of new onset chronic arthropathies or neurologic conditions in women receiving the RA 27/3 rubella vaccine vs unvaccinated women
• Is childhood vaccination associated with asthma? A meta-analysis of observational studies. – only looked at studies that directly compared vaccinated and unvaccinated children…
• The influence of measles vaccination on the incidence of otosclerosis in Germany. – found that the incidence of hospital treatments for otosclerosis decreased to a significantly greater extent in the vaccinated patients than in the unvaccinated patients.
• Measles-mumps-rubella and other measles-containing vaccines do not increase the risk for inflammatory bowel disease: a case-control study from the Vaccine Safety Datalink project – the MMR vaccine did not increase the risk for IBD, Crohn’s disease, or ulcerative colitis relative to unvaccinated children
• MMR vaccine and Crohn’s disease: ecological study of hospital admissions in England, 1991 to 2002 – like several other studies, found no increase in Crohn’s disease associated with the introduction of the MMR vaccination programme

Do we need even more studies on vaccinated vs unvaccinated children?

We already know that unvaccinated kids get sick more and they have more severe disease. Who is going to approve of or want to do a study that only puts kids at risk to get a vaccine-preventable disease?

Vaccines are safe, with few risks, and they are obviously necessary.

More on Vaccinated vs Unvaccinated Studies

• Do More Vaccinated or Unvaccinated Kids Get Sick in Outbreaks?
• What Is the Evidence for Alternative Vaccine Schedules?
• Vaccinated vs Unvaccinated – Measles Outbreak Edition
• Vaccinated vs Unvaccinated – Smallpox Edition
• Do Vaccinated Kids Who Get Sick Have Milder Disease?
• If It’s Vaccines, Then Why Are There Autistic Kids Who Are Unvaccinated?
• Where are the Double Blind Placebo Controlled Randomized Trials about Vaccines
• Where are the Saline Placebos?
• Two (now retracted) studies purporting to show that vaccinated children are sicker than unvaccinated children show nothing of the sort
• The perils and pitfalls of doing a “vaccinated versus unvaccinated” study
• Health of Vaccinated vs Unvaccinated
• Are unvaccinated children more healthy than vaccinated children?
• Calls by alternative medicine practitioners for vaccinated vs unvaccinated studies is not supported by evidence.
• And yet another vaccinated/unvaccinated comparison study, this time funded by SafeMinds
• About Those “Homeschooled, Unvaccinated Children are Healthier” Studies.
• Vaccinated vs Unvaccinated Overview
• “Let’s put on a Study!”
• Study – Vaccines are not associated with autism: an evidence-based meta-analysis of case-control and cohort studies.
• Study – Immunization uptake in younger siblings of children with autism spectrum disorder
• Fatality Rates Of Small-Pox In The Vaccinated And Unvaccinated
• Another Benefit of Vaccines: Milder Disease
• WHO – Epidemiology of the Unimmunized Child