Vaccines are very safe, but they are not 100% risk free.
They are certainly not as high risk as some anti-vaccine folks will have you believe though.
“Vaccine hesitation is associated with perceived risk. Since vaccine-preventable diseases are rare, an adverse event from a vaccine is perceived by the parent to be of greater risk. Risk perception is critical.”
AAP on Addressing Common Concerns of Vaccine-Hesitant Parents
And when you consider their great benefits, it is easy to see why the great majority of parents get their kids fully vaccinated and protected against all recommended vaccine-preventable diseases.
Risk Perception and Vaccine Hesitancy
Even though the risks and side effects of vaccines are very low, some people think that they are much higher. This is often amplified because of vaccine scare stories and the misinformation found on anti-vaccine websites.
“No intervention is absolutely risk free. Even the journey to a physician’s office with the intention to receive a vaccination carries the risk of getting injured in an accident. With regards to risks of vaccination per se, one has to distinguish between real and perceived or alleged risks.”
Heininger on A risk–benefit analysis of vaccination
Other problems with risk perception include that some people:
- can be more likely to avoid risks that are associated with an action or having to do something vs. those that involve doing nothing or avoiding an action, even if inaction (skipping or delaying a vaccine) is actually riskier
- often think about risks based on their own personal experiences (you remember someone’s vaccine injury story), rather than on scientific evidence
These biases in the way we think about risk can actually lead us to make risky choices and they help explain why some people are still so afraid of vaccines. Parents might think the risk of a possible side effect, some of which don’t even exist, is worse than the risk of getting a vaccine-preventable disease, getting someone else sick, or starting an outbreak. Parents also often underestimate the risk of their decision to not vaccinate their child.
“As much previous research claims, this study confirms that individuals characterized by greater trust of healthcare professionals and the possession of more vaccine-related knowledge perceive higher levels of benefits and lower levels of risks from vaccinations.”
Song on Understanding Public Perceptions of Benefits and Risks of Childhood Vaccinations in the United States
So what’s the answer? It is likely for folks to get better educated about vaccines, including getting a good understanding of both their benefits and risks.
What Are the Risks of Vaccines?
Again, vaccines are not 100% safe or risk free.
Most vaccines have some common, mild side effects, which might include (depending on the vaccine):

- fever, typically low-grade
- redness or swelling where the shot was given
- soreness or tenderness where the shot was given
- fussiness
- headache
- tiredness or poor appetite
- vomiting
- mild rash
- diarrhea
- swollen glands
How commonly do they occur?
It depends on the vaccine and side effect, but they range from about 1 in 50 to 1 in 3 people. These side effects are typically mild and only last a day or two. And they don’t cause lasting problems.
While not all possible side effects are mild, those that are more moderate or severe are much more uncommon. Febrile seizures, for example, only happen after about 1 out of 3,000 doses of MMR and some other vaccines. And while scary, febrile seizures, crying for 3 hours or more, or having a very swollen arm or leg, some other uncommon vaccine side effects, also don’t cause lasting problems.
Fortunately, the most severe side effects, including severe allergic reactions, are only thought to happen in less than 1 out of a million doses. And although these types of severe reactions can be life threatening, they are often treatable, just like severe allergic reactions to peanuts. For others, like encephalitis, although they are table injuries, it isn’t clear that they are even side effects of vaccines, since they occur so rarely.
All of these side effects can be reported to the Vaccine Adverse Event Reporting System (VAERS), either by your doctor or yourself.
“No medical product or intervention, from aspirin to heart surgery, can ever be guaranteed 100% safe. Even though we will never be able to ensure 100% safety, we know that the risks of vaccine-preventable diseases by far outweigh those of the vaccines administered to prevent them.”
World Health Organization
In addition to side effects, some other risks of getting vaccinated might include that your vaccine didn’t work, after all, although vaccines work very well, they are not 100% effective. You might also, very rarely, be given the wrong vaccine or the right vaccine at the wrong time.
Many other things, including so-called vaccine induced diseases, aren’t actually a risk of vaccines at all. Remember, autism, SIDS, multiple sclerosis, and shaken-baby syndrome, etc., are not a risk of vaccines.
What to Know About the Risks of Vaccines
Any small risks of getting vaccinated, including side effects that are often mild, are not a good reason to think about skipping or delaying a vaccine, especially when you thoughtfully consider all of their great benefits.
More About the Risks of Vaccines
- CDC – Possible Side-effects from Vaccines
- CDC – If You Choose Not to Vaccinate Your Child, Understand the Risks and Responsibilities
- AAP – Vaccines and Side Effects: The Facts
- WHO – Six common misconceptions about immunization
- Vaccine Side Effects and Adverse Events
- What to do about vaccine side effects
- Understanding Risks
- Vaccine Benefits vs Risks
- Vaccines and relative risks
- Vaccine Acceptance Still an Issue
- Delaying Vaccines Not A Good Idea
- In the wake of Wakefield: Risk-perception and vaccines
- Study – Vaccine hesitancy
- Study – Meta-analysis of the relationship between risk perception and health behavior: the example of vaccination.
- Study – A risk benefit analysis of vaccination
- Study – Understanding public perceptions of benefits and risks of childhood vaccinations in the United States.
I’m curious to know how people would feel if their doctor, the media, and the government all recommended that every man woman and child should receive a yearly, and/or scheduled, aluminum and thimerosal (mercury) injection. It would be the same amounts contained in vaccines, just without the rest of the vaccine. After all, this sort of aluminum is safe with only minor risks, and the amount of thimerosal is nearly zero. Would citizens still stand up and defend this form of medicine and require it of every citizen? When the FDA and CDC tell us how much aluminum is “safe” for us, they are talking about ingested aluminum, not injected aluminum. When a substance is injected into your soft tissue, it is not removed from the body in the same way as when it’s consumed and flushed through your digestive system. Your body has an immune response because it detects a poison and wants it removed as fast as possible. Furthermore, the “risks” are not always obvious in the first 7 days, or even the first 30-120 days after injection. We should demand long term and short term risk analysis of vaccines. We should demand clinical double blind placebo studies as well, which have never been done with vaccines. Any study showing the “safety” of vaccines is a study between a vaccine that is currently being used compared to a new one. That’s like verifying the absolute safety of injected diesel fuel by comparing it the safety of a petroleum injection. Would the outcome prove that diesel is a fairly safe thing to inject into the human body?