Tag: long-term

Are Vaccines Only Tested for 4 or 5 Days?

Where do some folks get the idea that vaccines are only tested for 4.5 days?

Anti-vax protestors often carry signs that say vaccines are only tested for 4.5 days. Don't believe them.
Anti-vax protestors often carry signs that say vaccines are only tested for 4.5 days. Don’t believe them.

The usual suspects…

Are Vaccines Only Tested for 4 or 5 Days?

But who gave them the idea to put it on their sign?

Again, the usual suspects…

Did the idea that vaccines are only tested for 4.5 days come from JB Handley, Children’s Health Defense Director and Co-Founder of Generation Rescue?
Did the idea that vaccines are only tested for 4.5 days come from JB Handley, Children’s Health Defense Director and Co-Founder of Generation Rescue?

Before we actually look to see if the original clinical trials for the hepatitis B vaccines only “solicited adverse reactions” for four or five days after vaccination, lets see what the safety studies have shown since these vaccines were approved in the 1980s.

These and other studies have shown that the hepatitis B vaccines are safe.

What about the idea that we only know what happens in the first four or five days after the vaccine is given?

Hepatitis B Vaccine Safety Testing

That’s not true. There are plenty of long term studies and safety studies typically collect safety information for weeks and months after a child is vaccinated.

“Open-ended diaries were provided to the parent(s) or guardian of the child before the vaccination program began in which to record any health problems that occurred 1 month before and 1 month following each of the 3 doses of vaccine, whether or not a health professional was consulted.”

De Serres et al on Importance of attributable risk in monitoring adverse events after immunization: hepatitis B vaccination in children.

Still, it is important to note that the further you get from a vaccination, the less likely that an adverse event is actually going to be caused by the vaccine though.

Consider the study by De Serres, Importance of attributable risk in monitoring adverse events after immunization: hepatitis B vaccination in children, in which they looked at the reports of adverse events both before and after vaccination and concluded that “postimmunization incidence systematically overestimates the risk of adverse events.”

Vaccines are tested very carefully, starting with small phase I and phase II trials, before moving to larger and longer lasting phase III trials.
Vaccines are tested very carefully, starting with small phase I and phase II trials, before moving to larger and longer lasting phase III trials.

It is also very important to note that like other vaccines, the hepatitis B vaccine was well tested before it was approved.

Although this was an efficacy trial, it included a double blind, placebo control and the researchers did notice any side effects.
Although this was an efficacy trial, it included a double blind, placebo control and the researchers did notice any side effects.

And many of the studies did include a placebo group.

A lot of folks in the placebo group for the hepatitis B vaccine trials got hepatitis B.
A lot of folks in the placebo group for the hepatitis B vaccine trials got hepatitis B.

Unfortunately, a lot of the folks in the placebo groups ended up getting hepatitis B.

In one study, Hepatitis B vaccine: efficacy in high-risk settings, a two-year study, which included an unvaccinated control group – “The control group was comprised of 31 patients and 24 staff members who had not been in contact with HBV until they entered the units and who did not wish to be vaccinated.”

What happens when you do a vaccinated vs unvaccinated study?
What happens when you do a vaccinated vs unvaccinated study?

Importantly, this study found “no local or general reaction to the immunization. A monthly biological and clinical survey of the vaccinated subjects showed no evidence of complication due to vaccination, especially no sign of auto­immunity.”

So why do we still hear the myth that vaccines are only tested for 4.5 days?

Anti-vax folks need to convince their followers that vaccines aren’t safe.

A careful look at all that went into the development of the hepatitis B vaccines shows that they are.

It also shows that vaccines are very necessary.

More on Hepatitis B Vaccine Safety Testing

How Long Do Side Effects of Immunizations Last?

Immunizations are safe, but they can have some risks and side effects.

Vaccine side effects can be reported to VAERS online or using a downloadable form.
Vaccine adverse events can be reported to VAERS online or using a downloadable form.

Fortunately, most are fairly mild, like pain and fever.

How Long Do Side Effects of Immunizations Last?

And most vaccine side effects go away quickly.

For example, fever and fussiness, two of the most common vaccine reactions, typically only lasts a day or two.

Others can last a little longer, but still usually go away on their own:

  • when kids get a rash after their MMR vaccine, it might last three or four days
  • even when kids get swelling of an entire arm or leg after the DTaP shot is given, it might last for 1–7 days
  • pain at the injection site typically only lasts a few days
  • shoulder injury related to vaccine administration (SIRVA) can last months and sometimes doesn’t go away
  • arthritis after a rubella containing vaccine, which mostly occurs in adults, typically only lasts a few days
  • febrile seizures are usually brief and rarely lead to non-febrile seizures
  • immune thrombocytopenic purpura (ITP) after a measles containing vaccine resolves in two weeks to six months, typically without any treatment
  • intussusception after a rotavirus vaccine resolves with treatment, either an air contrast enema or surgery
  • Guillain-Barré Syndrome after a seasonal flu vaccine, which is very rare, resolves in the majority of people over a period of years

Do any have more long lasting effects?

VAPP or vaccine-associated paralytic polio after the oral polio vaccine might not resolve. Fortunately, it only occurs in about 1 in every 1.27 million children receiving their first dose of OPV. It is even less common after bOPV, which is oral polio vaccine that is now being used. And won’t happen at all once we stop using oral polio vaccines.

Encephalitis or encephalopathy after a pertussis or a measles, mumps, and rubella virus containing vaccine might also lead to long lasting effects.

And some, like anaphylaxis, are life-threatening.

Fortunately, most long-term vaccine studies have shown that immunizations are safe, rarely causing severe reactions, and don’t have many long term side effects.

What to Know About How Long Immunization Side Effects Last

Most vaccine side effects are mild and only last a few days.

More on Immunization Side Effects

Are Vaccines Causing Long-Term Health Problems?

Did the CDC say that it is impractical to find out of vaccines are causing an epidemic of brain injury and other long-term health problems?

I’m guessing they didn’t…

Are Vaccines Causing Long-Term Health Problems?

Why does anyone think that they did?

The latest anti-vaccine propaganda about vaccines causing long-term health problems.
The latest anti-vaccine propaganda about vaccines causing long-term health problems.

Oh, anti-vaccine folks are sharing a cherry-picked quote from the CDC to scare parents away from vaccinating and protecting their kids.

Would you like to see the full quote?

“Observing vaccinated children for many years to look for long-term health conditions would not be practical, and withholding an effective vaccine from children while long-term studies are being done wouldn’t be ethical. A more practical approach is to look at health conditions themselves and at the factors that cause them. Scientists are already working to identify risk factors that can lead to conditions like cancer, stroke, heart disease, and autoimmune diseases such as lupus or rheumatoid arthritis. Thousands of studies have already been done looking at hundreds of potential risk factors. If immunizations were identified as a risk factor in any of these studies, we would know about it. So far, they have not.

We learn about a vaccine’s safety during clinical trials before it is licensed, and monitor it continually as millions of doses are administered after it is licensed. We also know there is not a plausible biologic reason to believe vaccines would cause any serious long-term effects. Based on more than 50 years of experience with vaccines, we can say that the likelihood that a vaccine will cause unanticipated long-term problems is extremely low.

Parents’ Guide to Childhood Immunizations

So no, the CDC didn’t say that it was impractical to find out of vaccines are causing an epidemic of brain injury.

Instead, they said that it was just impractical to do a study in which you give a child a vaccine and watch him for 20 years to see if he develops a problem, like leukemia, diabetes, or autism, all the while not giving the vaccine to other kids until your study is over. Of course, that’s because a lot of kids would get the potentially life-threatening disease that the vaccine is protecting those kids against while you were waiting to complete those long-term studies.

That’s not to say that we aren’t concerned about these types of long-term health problems occurring after a child is vaccinated.

Plenty of long-term safety studies have been done. It’s just more practical to do the studies on the diseases you are concerned about, sometimes after noticing safety signals, and see if vaccines truly are a risk factor.

Here is one example:

“In this large, population-based, case-control study, we did not find an increased risk of type 1 diabetes associated with any of the routinely recommended childhood vaccines.”

DeStefano et al on Childhood vaccinations, vaccination timing, and risk of type 1 diabetes mellitus.

In that study, they found all of the kids with diabetes born during 1988 through 1997 in the 4 health maintenance organizations (HMOs) that participate in the Vaccine Safety Datalink project of the Centers for Disease Control and Prevention, compared them to matched controls, and did not find an increased risk of type 1 diabetes associated with any of the routinely recommended childhood vaccines.

There are many more…

And that’s how we know vaccines aren’t causing long-term health problems.

Well at least those of us who did our research, looked for the original quote, and saw through this anti-vaccine propaganda.

More on Vaccines and Long-Term Health Problems

Are There Any Long-Term Studies On Vaccine Safety?

Vaccines are evaluated for safety in studies when they get approved.

Is that enough?

“I would like to see us do more long-term safety research studies on these large groups of children, so then we can determine that they are safe in the long-term.”

Bob Sears

Apparently not for everyone…

Are There Any Long-Term Studies On Vaccine Safety?

Of course, vaccines continue to be evaluated for safety after they approved, using passive and active vaccine safety systems and long-term post-marketing safety studies.

“We learn about a vaccine’s safety during clinical trials before it is licensed, and monitor it continually as millions of doses are administered after it is licensed. We also know there is not a plausible biologic reason to believe vaccines would cause any serious long-term effects. Based on more than 50 years of experience with vaccines, we can say that the likelihood that a vaccine will cause unanticipated long-term problems is extremely low.”

Parents’ Guide to Childhood Immunizations

These long term studies on vaccine safety have looked at:

Have you heard about these studies before?

When they talk about SV40, do anti-vaccine folks mention this long-term study?
When they talk about SV40, do anti-vaccine folks mention this long-term study?

Probably not.

Anti-vaccine folks either aren’t aware of, or just don’t want you to know about these types of long-term studies.

It’s easier to scare you away from vaccinating and protecting your kids if they make you believe that vaccines aren’t tested together, aren’t tested with placebos, aren’t tested vs unvaccinated kids, and aren’t tested for long periods of time.

They are!

More on Long-Term Studies On Vaccine Safety