Vaccine Information Statements (VISs) are produced by the CDC and help vaccine providers inform patients about the benefits and risks of the vaccines they are getting.
In fact, under the National Vaccine Childhood Injury Act, vaccine providers are required to give out a VIS before giving a vaccine, including those for:
Diphtheria, tetanus and pertussis containing vaccines (DTaP, DT, Td, and Tdap)
Haemophilus influenzae type b (Hib)
Human Papillomavirus (HPV)
Influenza (both Inactivated and Live, Intranasal vaccines)
Pneumococcal Conjugate (PCV13)
Unlike the package insert for a vaccine, “VISs are based on the ACIP’s recommendations, which occasionally differ from those made by the manufacturer. These differences may involve adverse events. Package inserts generally tend to include all adverse events that were temporally associated with a vaccine during clinical trials, whereas ACIP tends to recognize only those believed to be causally linked to the vaccine.” That makes the VIS a better tool to use when doing your research on a vaccine.
That vaccines contain antifreeze is also one of those anti-vaccine myths that continue to scare parents away from vaccinating and protecting their kids.
Some vaccines do contain 2-phenoxyethanol, which can be used as a stabilizer or preservative.
2-phenoxyethanol is not antifreeze though, although it kind of sounds like it.
Antifreeze is also called ethylene glycol. This is the type of toxic antifreeze that causes poisoning. It is a colorless, oderless, sweet liquid that is toxic to humans, cats, and dogs in very small amounts.
Propylene glycol, a component of non-toxic antifreeze, was once found in residual amounts in some flu vaccines.
What to Know About Antifreeze in Vaccines
Vaccines do not contain antifreeze or any other toxic ingredients.
From antigens and adjuvants to preservatives, learn about common ingredients in vaccines and why they are safe.
What’s in Vaccines?
It is no secret what’s in our vaccines.
A list of ingredients is included on the vaccine’s package insert and can be found on a number of articles on the Internet.
In addition to the active ingredients, the viral or bacterial antigens in the vaccine that you generate antibodies against, vaccines are made with a number of excipients, inactive substances or manufacturing by-products that are used to produce the vaccine:
preservatives – prevent bacterial and fungal contamination in multi-dose vials – thimerosal, 2-phenoxyethanol, phenol
adjuvants – help stimulate a stronger immune response so fewer antigens can be used – aluminum salts
stabilizers – maintain the potency of the vaccine and include sugars, amino acids, and proteins – lactose, MSG, gelatin
thimerosal – almost all vaccines, including over 130,000,000 flu vaccines this year, are thimerosal free!
aborted fetal tissue – there is no aborted fetal tissue or fetal parts in any vaccine, although some vaccines are made with fetal embryo fibroblast cells from cell lines that are derived (they can replicate infinitely) from two electively terminated pregnancies in the 1960s
Adjuvant 65 – an adjuvant that contained peanut oil that was tested with flu vaccines in the 1960s and continues to be blamed for causing peanut allergies, even though it has never been used in a vaccine
Although it was never actually linked to any real side effects, thimerosal (mercury) was removed from almost all childhood vaccines in 1999.
Thimerosal, a preservative, only remained in flu vaccines for a few years, but thimerosal free flu vaccines have been available since 2003.
That’s also the year that the remaining non-flu vaccines with thimerosal expired – January 2003.
And this year, at least “120 million doses of thimerosal-free or preservative-free influenza vaccine will be produced.” That means that over 75% of flu shots are thimerosal free, leaving only some multi-dose vials of flu shots to still have thimerosal, but making it easy to avoid if you want to.
Myth of Continued Exposure to Mercury in Vaccines
Although most anti-vaccine groups have moved on to other conspiracy theories to scare parents, some still falsely claim that vaccines continue to be made with thimerosal and that thimerosal is dangerous.
Robert F. Kennedy Jr., for example, continues to claim that even though thimerosal has been removed from pediatric vaccines, “thimerosal levels remain virtually unchanged.” This is mostly, he claims, because of flu shots with thimerosal. Also, when a pregnant woman gets a flu shot, Kennedy claims that the fetus gets a bolus of thimerosal “that’s about 800 times the amount of mercury the CDC recommends.”
First, it is important to remember that the original concerns about thimerosal were because children who received a complete set of thimerosal containing vaccines (only hepatitis B, DTaP, and Hib ever had thimerosal) could get up to 187.5 micrograms of ethyl mercury by the time they were six months old, which exceeded the EPA limits for methyl mercury ingestion (but was less than the FDA limits). They aren’t the same type of mercury though, and thimerosal free versions of DTaP and Hib were already available in the late 1990s, so many kids likely got less than 187.5 micrograms of ethyl mercury.
Since thimerosal was removed from almost all vaccines beginning in 1999, that left flu vaccines as the main pediatric vaccine that still used thimerosal as a preservative. So did expanded flu shot recommendations for kids mean that they still got a lot of thimerosal over the years?
It is extremely unlikely that many kids have gotten each and every one of their yearly flu vaccines with thimerosal. It is more likely that they got just a few with thimerosal and the rest without, as thimerosal free flu vaccines became more widely available. After all, a flu vaccine with reduced thimerosal was available as early as 2002.
In 2003, thimerosal free flu shots became available and Flumist, a thimerosal free flu nasal spray vaccine was also approved. The supply of thimerosal free flu vaccines increased each and every year. For the 2014-15 flu season, over 100 million doses of flu vaccine are available that are thimerosal free or preservative free (with only trace amounts of thimerosal).
Even if kids did get flu vaccines with thimerosal each year though, would it matter? A 2008 study in Pediatrics, “Mercury Levels in Newborns and Infants After Receipt of Thimerosal-Containing Vaccines,” found that the half-life of ethyl mercury was about two days, “suggesting that exposure to thimerosal-containing vaccines does not result in an accumulation of mercury in blood.” And the highest blood level they found was less than 5-8 nanograms/ml, which is far less than the 187.5 micrograms that anti-vax groups continue to talk about, even in infants who had already received a cumulative dose of 162.5 micrograms of thimerosal.
A 2010 study in Pediatrics, “Prenatal and Infant Exposure to Thimerosal From Vaccines and Immunoglobulins and Risk of Autism,” found that “prenatal and early-life exposure to ethylmercury from thimerosal-containing vaccines and immunoglobulin preparations was not related to increased risk of” autism spectrum disorders. Two other studies have also found that prenatal exposure to thimerosal from immunoglobulin preparations, like Rho(D) immune globulin, during pregnancy were not associated with an increased risk for autism.
And also consider that fewer than 15 to 30% of pregnant women got flu shots before 2009. After 2009 and the H1N1 pandemic, rates did increase, but only to about 38 to 52%.
Although current recommendations don’t state a preference for the type of flu shot for pregnant women, it is likely that at least some of them got thimerosal free flu shots. In California, for example, since the passage of their Mercury Free Act in 2006, pregnant women and children younger than age 3 years have to get vaccines that are ‘mercury free.’
What To Know About Thimerosal in Vaccines
Thimerosal is a preservative that was removed from vaccines beginning in 1999, which means that most teens today got little or no exposure to thimerosal from vaccines.