Tag: epigenetics

What Are the Signs of MTHFR Mutations?

Are you scared to vaccinate and protect your baby because you think she has signs of  MTHFR mutations?

What Are the Signs of MTHFR Mutations?

For some reason, some parents get concerned about MTHFR if their baby has:

  • a stork bite on the back of her neck (nevus simplex or salmon patch) – get it? that’s where the stork carriers the baby to you
  • a stork bite on the eyelids or forehead, although many people call it an angel’s kiss in these locations
  • a sacral dimple
  • a tongue-tie
  • any facial dimples
  • a strawberry hemangioma
  • a prominent blue vein on the bridge of her nose – called a sugar bug, because practitioners of traditional Chinese medicine think that it is linked to a sensitivity to sugar

And they somehow think that this a reason to delay or skip their child’s vaccines.

It isn’t.

Not surprisingly, none of the websites who list so-called signs of MTHFR mutations provide any evidence for why they are considered to be signs.

What Are the Real Signs of MTHFR Mutations?

If you are worried about MTHFR mutations, you have likely been warned that they cause a lot of different problems.

In reality, it is only known that MTHFR mutations can cause homocystinuria, a rare disorder of methionine metabolism. So you might expect those who have this mutation to have signs and symptoms of homecystinuria, including long limbs, chest deformities, and scoliosis, similar to Marfan syndrome.

Fortunately, many states now include testing for homecystinuria on their newborn screen.

Where Did the Other MTHFR Indicators Come From?

Some people also think that some common MHTFR polymorphisms, or gene variants, may be weakly associated with cardiovascular disease, migraines, anacephaly, spina bifida, and cleft lip and palate.

But this doesn’t mean that MHTFR mutations caused the child to have spina bifida or cleft lip and palate.

“In general, the following genotypes currently appear unlikely to be of clinical significance: “thermolabile” variant c.665C→T heterozygote, c.1286A→C homozygote, or (c.665C→T); (c.1286A→C) compound heterozygote.”

Hickey et al. on ACMG Practice Guideline: lack of evidence for MTHFR polymorphism testing

These polymorphisms are very common and you are going to find them when you look for them.

More and more studies are now finding that they are not associated with any diseases or extra risk of disease. And any risk for neural tube defects in pregnancy can be eliminated by taking folate supplements, which is now recommended for all pregnant women anyway.

But you now should be able to see where their list of bogus signs of MTHFR mutations came from. If spina bifida is supposed to be associated with MTHFR polymorphisms, then why not sacral dimples? And if cleft lip and palate is supposed to be associated with MTHFR polymorphisms, then why not tongue-tie?

Neither a stork bite nor tongue-tie is a sign of a MTHFR mutation. Photo by Vincent Iannelli, MD
Neither a stork bite nor tongue-tie is a sign of MTHFR mutations. Photo by Vincent Iannelli, MD

What about stork bites, hemangiomas, facial dimples, and the blue vein?

These are some of the most common things that pediatricians point out to parents during their first few appointments. New parents especially what to be reassured that all of these things, which can be very obvious, are eventually going to go away. And fortunately, they typically do – without treatment, although some hemangiomas do require treatment.

In fact, it is estimated that 30 to 50% of newborns have a stork bite. These dilated blood vessels typically go away without treatment. How many people have MHTFR polymorhisms? Yup, 30 to 50%. And no, that doesn’t mean that MHTFR polymorhisms cause stork bites.

Again, since MHTFR polymorhisms are common variants (not mutations that cause disease), you are going to find them associated with many other common conditions.

“Midline lumbosacral skin lesions (e.g., lipomas, dimples, dermal sinuses, tails, hemangiomas, hypertrichosis) are cutaneous markers of spinal dysraphism. A comprehensive review of 200 patients with spinal dysraphism found that 102 had a cutaneous sign. However, many children without spinal dysraphism also have these skin findings.”

McLaughlin et al. on Newborn Skin: Part II. Birthmarks

It is also very possible that folks are misunderstanding a recommendation about warnings for risks of occult spinal dysraphism. This occurs when there is incomplete fusion of the midline elements of the spine, but they are covered by skin, so unlike spina bifida, they are hard to detect. So we look for things like hemangiomas, hypertrichosis (hairy patches), nevus simplex (stork bite), and dimples, etc., as a sign that something might be wrong underneath the skin.

In general, if you have two or more of these skin lesions, a child’s risk for occult spinal dysraphism would be considered high, but, and this is important, the location of the skin lesions is what we look for. They would be over the midline lumbosacral area (the lower back). So an hemangioma on your child’s arm or chest wouldn’t be a risk. Neither would a stork bite on the nape of a baby’s neck or an angel kiss on their forehead.

But now you see the assumed link to MTHFR!

‘They’ think  that MTHFR mutations cause spina bifida, so they made the jump to all of these possible signs of occult spinal dysraphism being associated with MTHFR polymorpisms too, even when they aren’t actually signs of occult spinal dysraphism unless they are located on your baby’s lower back.

“MTHFR gene mutations can cause absolutely no symptoms at all. They can also cause severe irreversible health conditions such as Down’s syndrome. Research is still pending on which medical conditions are caused by, or at least partially attributed to, the MTHFR gene mutations. From the partial list I recently went through on Medline, these are the current symptoms, syndromes and medical conditions relating to the MTHFR gene mutations:”

Ben Lynch on MTHFR Mutations and the Conditions They Cause

A lot of what folks think they know about MTHFR mutations comes from Ben Lynch, who has a doctorate in Naturopathic Medicine (ND), recommends that folks get genetic testing, and then tells them all of the things that are wrong with them when the tests come back.

“Many of your health issues spring from a combination of overworked and underworked genes. These issues can often be resolved by supporting your genes—but you don’t know that.”

Ben Lynch on My Mission: Reach Your Genetic Potential

And even smarter mission would be to skip the genetic testing, especially if it includes MTHFR testing, and get your family vaccinated and protected.

What to Know About Signs of MTHFR Mutations

There are no signs of MTHFR mutations that you should be looking for that would indicate you should skip or delay any of your child’s vaccines.

More on Signs of MTHFR Mutations

Who Is Kelly Brogan?

Kelly Brogan is a holistic psychiatrist.

Why am I writing about a holistic psychiatrist?

More specifically, Kelly Brogan is a women’s health holistic psychiatrist who doesn’t seem to believe that vaccines are safe, that vaccines work, or that vaccines are necessary.

They are.

“…we have been recently convinced through the promise of technology and corporate prowess that processed food is more reliable, nutritious, and beneficial. We’ve been convinced that Hamburger Helper is better for our families than a homemade Bolognese.”

Kelly Brogan

For some reason, she does not seem to be vegan, as one might expect. Not even vegetarian…

She does seem to believe that people with mental health conditions not should be treated with medication. In fact, she thinks the medications that are routinely used to treat common mental health conditions are behind some of the biggest tragedies happening today.

“The records also listed attention deficit hyperactivity disorder as one of his medical conditions” the proverbial smoking gun of every mass shooting in this country.”

Kelly Brogan on the Sutherland Church Shooting

And she was mentored, not by a psychiatrist, but by a doctor who pushed “a largely dietary treatment for cancer including an individualized organic diet, large amounts of supplements, and pancreatic enzymes,” a regimen that was actually studied and found to be harmful and reduced the quality of life for people with a deadly form of cancer.

Who Is Kelly Brogan?

Kelly Brogan is a holistic psychiatrist.

“Eastern wisdom tells us that when we think we know, we don’t. But when we admit ignorance, we achieve enlightenment. The most profound part of my departure from conventional medicine has been the depths of my surrender to all that we do not, cannot, and must not understand about the body and its experience. Humble awe and wonder are truly the only appropriate states for approaching the complexity of the human condition.”

Kelly Brogan

Do holistic psychiatrists use a different definition for the word humble?

“All suffering is caused by ignorance. People inflict pain on others in the selfish pursuit of their own happiness or satisfaction.”

Dalai Lama XIV

Kelly Brogan, a holistic psychiatrist, also pushes a lot of anti-vaccine talking points about epigenetics, germ theory denialism, MTHFR, and the need for detoxing from vaccines.

These beliefs can cause suffering if she can get others to believe them too, as can pushing the idea that babies shouldn’t get their hepatitis B vaccine or a vitamin K shot.

I’m actually surprised that she hasn’t written about RhoGAM. Maybe she hasn’t gotten around to it. But she doesn’t disappoint. She has shared an article on her Facebook page that claims that the RhoGham shot is just a “Big Pharma Profit Ploy.”

Kelly Brogan is a holistic psychiatrist that wants you to live a medication free life. I guess that could have made her some kind of psychoanalysist, but that doesn’t seem to be the route she went.

“In fact, ‘treatment’ with chemotherapy and radiation not only disrupts a complex process that needs to actually be supported, but also it induces secondary harm, both psychically and physiologically. When we interfere and war with the body, we keep the fight alive – you can’t win the battle against yourself.”

Kelly Brogan

Is she telling people to stop their cancer treatments?

Do folks get a lot of training in treating cancer in their psychiatry residency these days?

And she advises that you “think long and hard about vaccination.”

“As we discover more about the near infinite sophistication of your interconnected bodily systems, and the hyper-individuality of any cause and effect process resulting from a healthcare decision, the one-size-fits-all, indemnified vaccine program may begin to make less and less sense to you. Educate yourself before you make a choice that could change everything for you and your family. Trust your body. Invest in your immunity. And explore a mindset shift that offers you a fear-free way to understand health and wellness.”

Kelly Brogan

Shortly after talking about informed consent, she lets you know how she really feels about vaccines.

“Don’t buy into the lore, don’t make assumptions, and understand that the philosophical underpinnings of the vaccination program are predicated on an antiquated perspective: warring against and attempting to eradicate bad germs. Science has left that childlike notion in the dust, and so should we.”

Kelly Brogan

I think Dr. Brogan misspelled pseudoscience

Why don’t you need to get your kids vaccinated and protected? Because Kelly Brogan has a “tremendous faith in the potential for the body to heal when naturally supported.”

Do you?

Will you during a measles outbreak?

“One of my favorite medical terms, anosognosia, means lack of awareness of a deficit. I have come to find this useful in description of so many of my colleagues who practice the medicine they were trained to practice without conscious acknowledgement of its gross limitations and even hazards.”

Kelly Brogan

Kelly Brogan didn't make history in getting a case report published in a low impact journal who's editorial board includes a Reiki Master, chiropractors, and naturopaths.
Kelly Brogan didn’t make history in getting a case report published in a low impact journal who’s editorial board includes a Reiki Master, chiropractors, and naturopaths.

Does anyone else think that it is wildly ironic that anosognosia is Kelly Brogan’s favorite medical term?

Psychiatry explains Kelly Brogan well.

Actually, it might be cognitive psychology that explains her actions.

Can a psychiatrist be suffering from the Dunning-Kruger effect?

I don’t know, but I’m pretty sure that a holistic psychiatrist can.

A history-making case report? Considering that case reports are the weakest type of scientific evidence, just above YouTube videos and articles on her website, that’s not likely.

Kelly Brogan is a holistic psychiatrist who has flirted with HIV denialism.

You can get educated about vaccines if you are on the fence, but it won’t be from Kelly Brogan, a women’s health holistic psychiatrist.

What to Know About Kelly Brogan

Kelly Brogan is a holistic psychiatrist who seems to charge folks a lot of money in private consultations to help them know that she has faith in their potential to heal themselves naturally – with her help.

More About Kelly Brogan

Updated December 2, 2017