Tag: research

Best Vaccine Websites

Need to do your research and get educated about vaccines?

There are plenty of great vaccine books to turn to.

Best Vaccine Websites

Rather use the Internet?

Caveant lector et viewor — Let the reader and viewer beware.

Silberg et al, on Assessing, controlling, and assuring the quality of medical information on the Internet

Unfortunately, you can’t just trust any website that pops up at the top of your search results on Google, Bing, or Yahoo or that is shared by a friend on Facebook. Some of these sites might push misinformation about vaccines and be filled with anti-vaccine talking points.

Whether you are on the fence or just have a few questions, instead of feeling lucky that Google will lead you to trusted information, start your research about vaccines on the following websites. They are the most reliable and trusted sources of immunization information you will find.

  1. American Academy of Pediatrics
  2. Centers for Disease Control and Prevention
  3. World Health Organization
  4. Every Child By Two
  5. EZIZ
  6. Families Fighting Flu
  7. Gavi The Vaccine Alliance
  8. Harpocrates Speaks
  9. History of Vaccines
  10. Immunise Australia
  11. Immunisation Scotland
  12. Immunization Action Coalition
  13. The Immunization Advisory Centre
  14. Immunize Canada
  15. Immunize for Good
  16. Institute for Vaccine Safety
  17. I Speak of Dreams
  18. Just the Vax
  19. Left Brain Right Brain
  20. Measles & Rubella Initiative
  21. Moms Who Vax
  22. National Foundation for Infectious Diseases
  23. National Meningitis Association
  24. NHS
  25. Northern Rivers Vaccination Supporters
  26. Nurses Who Vaccinate
  27. Parents of Kids with Infectious Diseases
  28. The Poxes Blog
  29. Pro-Vaccine Parenting Group (Facebook)
  30. Shot of Prevention
  31. Skeptical Raptor
  32. TIP Talk
  33. Vaccinate Your Family
  34. the Vaccine Blog
  35. Vaccine Education Center
  36. the Vaccine Mom
  37. the Vaccine Page (Facebook)
  38. Vaccines on the Fence (Facebook Group)
  39. Vaccines Work
  40. Voices for Vaccines

Other websites that are also reliable sources of immunization information, but don’t focus on vaccines include:

Get all of your questions answered yet?

Your pediatrician should also be a good resource for questions about vaccines.

Evaluating Vaccine Websites

Be skeptical if looking elsewhere.

Some general questions experts recommend asking, and which will certainly help when visiting a website about vaccines, include:

  • Who runs the Web site?
  • Who pays for the Web site?
  • What is the Web site’s purpose?
  • What is the original source of the Web site’s information?
  • How does the Web site document the evidence supporting its information?
  • Who reviewed the information before the owner posted it on the Web site?
  • How current is the information on the Web site?
  • How does the Web site owner choose links to other sites?

Fortunately, anti-vaccine websites are fairly easy to spot.

Anti-vaccine websites often filled with conspiracy theories, talk about BigPharma, and about how everyone else is hiding the truth about vaccines.
Anti-vaccine websites often filled with conspiracy theories, talk about BigPharma, and ideas about how everyone else is hiding the truth about vaccines.

They are often filled with vaccine injury stories and articles about how vaccines are filled with poison (they aren’t), don’t really work (they do), and aren’t even needed (they certainly are).

Tragically, their pseudo-scientific arguments can sometimes be persuasive, especially if you don’t understand that they are mostly the same old arguments that the anti-vaccine movement has been using for over 200 years to scare parents away from vaccinating and protecting their kids.

What to Know About the Best Vaccine Websites

With current information, a clear purpose (informing users, not selling supplements in an online store), and authors who are well-respected, our collection of the best vaccine websites can help you get educated about vaccines from a trusted source.

More on the Best Vaccine Websites

Vaccine Testing and Development Timeline and Myths

New vaccines must go through a long journey before they are finally approved by the FDA and get added to the recommended immunization schedule.

vaccine-dev-testing

Vaccine Testing and Development Myths

There are many myths and much misinformation surrounding vaccine testing and development that is used to scare parents away from vaccinating their kids.

Have you heard that vaccines aren’t tested together?

Or that flu vaccines or Tdap were never tested on pregnant women?

Then there are the myths about fast-tracking, and that important steps are skipped when a vaccine is on fast track for FDA approval, or that the whole vaccine testing and development process happens very quickly.

Vaccine Testing and Development Timeline

The vaccine development process is anything but quick.

“Vaccine development is a long, complex process, often lasting 10-15 years and involving a combination of public and private involvement.”

The History of Vaccines on Vaccine Development, Testing, and Regulation

During this time of the exploratory and pre-clinical stage research and then phase 1,2, and 3 trails, vaccines are:

  • tested on animals
  • tested on small groups of people
  • tested on larger groups of people
  • tested alone
  • tested together with other vaccines
  • tested for safety
  • tested for efficacy (to make sure they work)

This often includes double-blind, placebo controlled vaccine trials.

Fast tracking does speed the process up, but not because any of the testing is skipped. The researchers just get more frequent meetings and communication with the FDA and “Eligibility for Accelerated Approval and Priority Review, if relevant criteria are met.”

“Vaccine development is a complex multidisciplinary activity, combining understanding of host-pathogen interactions at the molecular level, with clinical science, population-level epidemiology and the biomechanical requirements of production.”

Anthony L. Cunningham, et al on Vaccine development: From concept to early clinical testing

Testing doesn’t stop once a vaccine is approved by the FDA and is added to the immunization schedule either. We often continue to see testing for vaccine safety and efficacy using phase 4 trials and with our post-licensure vaccine safety system, including VAERS and the Vaccine Safety Datalink.

And of course testing continues long after we begin using vaccines to see how long their protection will last. For example, because of continued testing, we now know that Gardasil and Cervarix are providing protection that lasts at least 8 and 9 years.

What To Know About Vaccine Testing and Development

From pre-clinical studies and years of phase 1, 2, and 3 trials to continued monitoring after a vaccine is approved and added to the immunization schedule, the vaccine testing and development process helps make sure that vaccines are safe and that they work.

More About Vaccine Testing and Development

Are Vaccines Tested Together?

If you are on the Fence about vaccines, one issue that might have you scared is that the idea that vaccines aren’t tested together.

So maybe they tested the Prevnar vaccine, but did they test it with the Hib vaccine?

And did they test the Prevnar and Hib vaccine with the Pediarix vaccine?

After all, kids get all of those vaccines at their two, four, and six month well child checkups.

Vaccines Are Tested Together

It is not hard to find evidence that most combinations of vaccines are in fact tested together.

For example (and this is not a complete list):

  • Rotarix was tested with Pediarix (DTaP-HepB-IPV), Prevnar, and Hib
  • Prevnar 13 was tested with DTaP, IPV, hepatitis B and Hib
  • Prevnar 13 was tested with MMR, Varicella, and hepatitis A
  • MenC with DTaP-IPV-HepB-Hib
  • MenC with MMR
  • MMR and Varicella with Hib, Hepatitis B, and DTaP
  • hepatitis A and hepatitis B with either MMR or DTaP-IPV-Hib
  • HPV vaccine for babies
  • Flumist with MMR and Varicella
  • Kinrix (DTaP-IPV) with MMR and Varicella
  • HPV9 with Tdap and Meningococcal vaccines
  • Tdap with influenza vaccine
  • Meningococcal vaccine with influenza vaccine

And even after a vaccine is added to the immunization schedule and it is given together with other vaccines, our post-licensure vaccine safety monitoring systems, from VAERS to the Vaccine Safety Datalink, kick in to make sure that they are indeed safe and effective.

The Myth That Vaccines Aren’t Tested Together

If it is clear that vaccines are in fact tested together, then why do some folks still believe that they aren’t?

Bob Sears appeared on Fox & Friends in 2010 for the segment
Bob Sears appeared on Fox & Friends in 2010 for the segment Vaccines: A Bad Combination?

Hopefully everyone sees the irony in Dr. Bob saying something about vaccines being untested, as he is infamous for pushing his own made up and completely untested alternative vaccine schedule.

“Babies get as many as 6 or 7 vaccines altogether…and the CDC is admitting that they don’t always research them that way.”

Dr. Bob Sears on Fox & Friends Vaccines: A Bad Combination?

When did they admit that???

“We’ve researched the flu vaccine in great detail and it seems safe when it’s given alone, but the CDC has never researched the flu vaccine when you give it in conjunction with all the other infant shots…and that’s what we’re worried about. ”

Dr. Bob Sears on Fox & Friends Vaccines: A Bad Combination?

So, what about the flu vaccine?

A 2013 report from the Institute of Medicine found that there was no evidence that vaccines caused ADHD.
A 2013 report from the Institute of Medicine stated that “Each new vaccine considered for inclusion in the immunization schedule is tested within the context of the existing schedule and reviewed by clinical researchers, who analyze the balance of demonstrated benefits and risks.”

While most kids get their flu vaccine by itself, just before the beginning of flu season, some might get it when they see their pediatrician for a regular checkup, at the same time they are due for other vaccines.

Not surprisingly, Dr. Bob was wrong, and several studies have shown that the flu vaccine can be safely given with other vaccines.

And don’t forget, any problems with co-administration of vaccines would show up in post-licensure vaccine safety testing.

That’s how a very small increased risk of febrile seizures was found during the 2010-11 flu season in toddlers who received either DTaP or Prevnar and a flu shot at the same time.

The very small extra risk doesn’t mean that you still can’t get the vaccines at the same time if your child needs them all though. Remember that febrile seizures “are temporary and do not cause any lasting damage.”

It will be even more reassuring to some parents that another study “examined risk of febrile seizures (FS) after trivalent inactivated influenza vaccine (TIV) and 13-valent pneumococcal conjugate vaccine (PCV13) during the 2010-2011 influenza season, adjusted for concomitant diphtheria tetanus acellular pertussis-containing vaccines (DTaP)” and found no extra risk for febrile seizures.

“Vaccines can generally be co-administered (i.e. more than one vaccine given at different sites during the same visit). Recommendations that explicitly endorse co-administration are indicated in the table, however, lack of an explicit co-administration recommendation does not imply that the vaccine cannot be co-administered; further, there are no recommendations against co-administration.”

Summary of WHO Position Papers – Recommendations for Routine Immunization

Also remember that “there are no recommendations against co-administration of vaccines,” unless of course, you are getting your advice from Bob Sears…

 

What To Know About Vaccines Being Tested Together

Vaccines are thoroughly tested for both safety and efficacy and they are also tested in many of the different combinations on the routine childhood immunization schedule.

More On Vaccines Being Tested Together

Are You on the Fence About Vaccines?

If you have doubts about vaccinating your kids, but you are still doing research, then you are probably what people like to call a fence sitter.

On the Fence About Vaccines

Folks who are on the fence haven’t made a decision yet and are torn between what they see as two difficult options.

In this case, the two options we are talking about are:

  1. vaccinate your kids
  2. don’t vaccinate your kids

What makes those options difficult?

If you spend a little time on the Internet, those two options get complicated quickly and can turn into:

  1. vaccinate your kids – exposing them to toxins and all kinds of vaccine-induced diseases, from autism to SIDS
  2. don’t vaccinate your kids – risking a deadly disease because they are unvaccinated or the possibility that someone will come and force you to get them vaccinated

How do you figure out the truth to help you make the right decision for your family?

The Truth Behind Your Vaccine Decision

Most parents vaccinate their kids on time and on schedule.

These books about vaccines can help with your research about vaccinating and protecting your family.
These vaccine books can help you make the right decision if you are on the fence about vaccines.

Do they all have a hard time making their decision?

Most don’t.

They understand the risks their children face if they aren’t vaccinated.

“When a well-meaning parent like Jenny McCarthy blames vaccines for her child’s autism, placing the fear of God into every parent who has a baby, it’s not only irresponsible – it’s dangerous. Why? It’s simple math: vaccines are less effective when large numbers of parents opt out. And the more who opt out, the less protected ALL our children are.

Celebrity books come and go . . . but the anxiety they create lives on in pediatricians’ offices across the country. A small, but growing number of parents are even lying about their religious beliefs to avoid having their children vaccinated, thanks in part to the media hysteria created by this book.”

Ari Brown, MD responding to Jenny McCarthy appearing on Oprah

That’s not to say that they don’t think about their decision to vaccinate their kids. Or even think twice about it.

But in the end, they know that:

  • vaccines work – even if they aren’t perfect and waning immunity is an issue with a few vaccines
  • vaccines are safe – even if they do have some side effects, which can rarely be severe
  • vaccines are necessary – without them, we would end up in like it was in the pre-vaccine era, even with modern health care, nutrition, and sanitation, etc.

And they know that their decision might affect others around them.

If your research about vaccines has pushed you off the wrong side of the fence and into your pediatrician’s office with a copy of Dr. Bob’s vaccine book demanding an alternative immunization schedule, then you might want to do a little more research.

Misinformed Consent

Most importantly, parents who choose to vaccinate their kids don’t believe the myths and conspiracy theories that might lead them to skip or delay any recommended vaccines.

“If you see a turtle sitting on top of a fence post, it didn’t get there by accident.”

President Bill Clinton

Ironically, the anti-vaccine “experts” and websites that scare some parents often talk about choice and informed consent.

Understand though, that by exaggerating the risks of vaccines and vaccine injury (no, vaccines are not full of toxins), playing down the risks of vaccine-preventable diseases (no, they are not mild diseases that should be thought of as a rite of passage), and ignoring the benefits of vaccines (yes, vaccines do work), they are violating the basic tenets of informed consent themselves.

And that limits your ability to make the right choice for your family.

Making the Right Decision About Vaccines

There is nothing wrong with asking questions and being skeptical about the answers you get.

No one wants to return to the days when reports of measles epidemics made the front page of the New York Times.
No one wants to return to the days when reports of measles epidemics made the front page of the New York Times.

With all of the things you see and hear about vaccines, there is nothing wrong with being a little scared and wanting to do more research, instead of blindly following the advice of your pediatrician.

But remember that if you are going to be skeptical and are not going to blindly follow the advice of someone you know and maybe trust, then don’t blindly believe everything you read on the Internet that says vaccines are bad.

“My husband and I agreed we would just not have our new baby vaccinated until she was at least 1 year old, which seemed like enough time to continue looking for information. Also, we were not concerned that she was at risk of contracting any serious childhood illnesses.

We were wrong.

A week before our baby girl’s first birthday, she was feverish and listless. When she refused to nurse for 24 hours, I took her to see our pediatrician. She was hurriedly admitted to intensive care with the diagnosis of spinal meningitis caused by Haemophilus influenzae, type B, which is a vaccine-preventable disease.”

Suzanne Walther on A Parent’s Decision on Immunization: Making the Right Choice

Suzanne Walther discovered that “it is easy for parents to be misinformed. It is a real challenge to be well informed.”

What questions did she want answers to?

  • Are vaccines really effective at preventing diseases? – Yes, although they aren’t 100% effective, vaccines do work well at preventing and controlling 16 different vaccine-preventable diseases on our childhood immunization schedule. And yes, vaccines did help eliminate smallpox and herd immunity is real.
  • How are vaccines made? – Vaccines are made in a multi-step process that begins with generating the antigens that will go in the vaccine and then moves to releasing and isolating the antigen from the growth medium, purifying the antigen, strengthening and stabilizing the vaccine, and then combining it all into the final vaccine. Unlike videos you may have seen on the Internet, there is nothing scary about this very scientific process.
  • Are they tested for safety? – Vaccines are extensively tested in Phase I, II, and III trials before they are approved and added to the immunization schedule. This entire vaccine development process may take as long as 10 to 15 years.
  • Are there ongoing clinical trials to rule out the possibility that vaccines cause diseases later in life? – Yes, after vaccines are approved and are added to the immunization schedule, ongoing Phase IV studies continue to monitor their safety and efficacy. In addition, Vaccine Adverse Event Reporting System (VAERS), the Clinical Immunization Safety Assessment (CISA) Project, and the Vaccine Safety Datalink (VSD) help make sure vaccines are safe after they are approved.
  • Have allegations of adverse reactions been studied and confirmed or refuted? – Yes. In addition to several Institute of Medicine Vaccine reports, study after study have shown that vaccines don’t cause autism, SIDS, ASIA, or any of the other vaccine induced diseases “they” come up with.
  • And, last but not least, where can I get truthful, clear answers to my questions? – In addition to your pediatrician, there are plenty of vaccine books, sites, and groups that can help you get educated about vaccines.

Today, she might also have had questions about package inserts, aluminum, MTHFR mutations, shedding, vaccine mandates, the CDC Whistleblower, and the HPV vaccine. These and a hundred more have been answered over and over again.

Suzanne Walther learned about vaccines the hard way – after her infant contracted Hib meningitis, a vaccine-preventable disease. She also discovered that you can sometimes delay or wait too long to vaccinate your child.

What will you do to be well informed and to make sure you are making the right choice?

What to Know If You Are on the Fence About Vaccines

It is easy to be misinformed about vaccines, especially if you are on the fence and aren’t sure what to do. Get educated and and be sure you are making the right decision for your family.

More About One the Fence About Vaccines

National Immunization Awareness Month

This year, we celebrate the 17th annual National Immunization Awareness Month.

History of National Immunization Awareness Month

The National Partnership for Immunization first designated August as National Immunization Awareness Month in 2001.

“NIAM was officially announced to the media and the immunization community with a kickoff event at the National Press Club on August 1, 2001. Key stakeholders, including maternal and child health professionals, immunization advocates and policymakers participated in a press conference and reception in Washington, D.C. to celebrate the initiation of this yearly event.”

Are you up-to-date? Vaccinate! An early theme of National Immunization Awareness Month.
Are you up-to-date? Vaccinate! An early theme of National Immunization Awareness Month.

In addition to giving awards to a few members of Congress, the TV show ER got a media award at the first National Immunization Awareness Month because the show “portrayed the importance of vaccinations using the story of an unvaccinated child who was sent to the emergency room and subsequently died from measles. The episode effectively relayed the important messages that measles still occurs in this country, that the disease can be deadly and that it can be prevented by immunization.”

In 2006, the CDC “took over” National Immunization Awareness Month, continuing NPI’s campaign focused around the theme, “Are You Up to Date? Vaccinate!”

Unfortunately, the CDC didn’t really sponsor the month. They just recognized that it was happening on their website…

“While CDC does not sponsor this month, CDC does support and encourage the efforts of state and local health departments and other immunization partners to celebrate NIAM and use this month to promote back to school immunizations, remind college students to catch up immunizations before they move into dormitories, and remind everyone that the influenza season is only a few months away. It’s a great reminder to our nation that people of all ages require timely immunization to protect their health.”

It wasn’t until 2013 that National Immunization Awareness Month really came back.

That’s when the National Public Health Information Coalition started coordinating NIAM activities, including key messages, sample media materials, social media content, and event ideas to:

  • Encourage parents of young children to get recommended immunizations by age two
  • Help parents make sure older children, preteens, and teens have received all recommended vaccines by the time they go back to school
  • Remind college students to catch up on immunizations before they move into dormitories
  • Educate adults, including healthcare workers, about vaccines and boosters they may need
  • Educate pregnant women about getting vaccinated to protect newborns from diseases like whooping cough (pertussis)
  • Remind everyone that the next flu season is only a few months away

In 2014, NIAM began to also focus on a different stage of the lifespan each week, from infants, children and teens to pregnant women and adults.

National Immunization Awareness Month 2017

What’s going on in #NIAM17?

In addition to adding a ‘Back to School’ category for school age children that lasts throughout the month to make sure kids are ready for school, NAIM17 continues with different themes each week:

  • Vaccines are safe. Vaccines are necessary. Vaccines work. These are good messages to learn in NIAM17.
    Vaccines are safe. Vaccines are necessary. Vaccines work. These are good messages to learn in NIAM17.

    Babies and Young Children: A healthy start begins with on-time vaccinations. (July 31-August 6)

  • Pregnant Women: Protect yourself and pass protection on to your baby. (August 7-13)
  • Adults: Vaccines are not just for kids. (August 14-20)
  • Preteens/Teens: Ensure a healthy future with vaccines. (August 21-27)

Are your kids up-to-date?

National Immunization Awareness Month is a great time to get educated about vaccines and learn that:

  • Vaccines protect against serious diseases.
  • These diseases still exist and outbreaks do occur.
  • Vaccines are recommended throughout our lives.
  • Vaccines are very safe.

It’s also a good time to learn how to avoid getting scared by anti-vaccine talking points and the misinformation pushed by the anti-vaccine movement.

What To Know About National Immunization Awareness Month

National Immunization Awareness Month is a great time to learn why vaccinating and protecting your family is an important and safe decision.

More About National Immunization Awareness Month

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Best Books to Help You Research Vaccines

There are many books to help you get educated about vaccines and avoid getting influenced by vaccine scare stories and anti-vaccine talking points.

Some can even help you understand why you are afraid of vaccines.

Unfortunately, if you simply search Amazon for books about vaccines, you are going to be hit with a list of anti-vaccine books. These are books that push their own made-up, so-called alternative immunization schedules and misinformation about vaccines to scare you away from vaccinating and protecting your kids.

Best Vaccine Books

Which books about vaccines have you read?

Did you even realize you had so many choices?

These books about vaccines can help with your research about vaccinating and protecting your family.
These books about vaccines and vaccine-preventable diseases can help with your research about vaccinating and protecting your family.

Some of my favorite vaccine books that can help you with your research on vaccination and making the right decision for your child include:

  • Autism’s False Prophets. Bad Science, Risky Medicine, and the Search for a Cure
  • Bad Faith: When Religious Belief Undermines Modern Medicine
  • Bad Science: Quacks, Hacks, and Big Pharma Flacks
  • Calling the Shots: Why Parents Reject Vaccines
  • The Cutter Incident: How America’s First Polio Vaccine Led to the Growing Vaccine Crisis
  • Dangerous Pregnancies: Mothers, Disabilities, and Abortion in Modern America
  • Deadly Choices. How the Anti-Vaccine Movement Threatens Us All
  • Do Vaccines Cause That?!
  • Do You Believe in Magic? The Sense and Nonsense of Alternative Medicine
  • Immunity by William E. Paul, MD
  • On Immunity: An Inoculation
  • NeuroTribes: The Legacy of Autism and the Future of Neurodiversity
  • The Panic Virus: A True Story of Medicine, Science, and Fear
  • Panicology: Two Statisticians Explain What’s Worth Worrying About (and What’s Not)
  • Polio. An American Story
  • Polio Wars: Sister Kenny and the Golden Age of American Medicine
  • Pox. An American History
  • Smallpox and the Literary Imagination, 1660-1820
  • Tabloid Medicine: How the Internet is Being Used to Hijack Medical Science for Fear and Profit
  • Twin Voices: A Memoir of Polio, the Forgotten Killer
  • Vaccinated. One Man’s Quest to Defeat the World’s Deadliest Diseases
  • Vaccination: A History from Lady Montagu to Genetic Engineering
  • Vaccine. The Controversial Story of Medicine’s Greatest Lifesaver
  • The Vaccine Race: Science, Politics, and the Human Costs of Defeating Disease
  • Vaccines and Your Child. Separating Fact from Fiction
  • Your Baby’s Best Shot. Why Vaccines Are Safe and Save Lives

How many of these books about vaccines have you read?

What To Know About Vaccine Books

If you were scared away from vaccinating your kids because of a book you read or something you saw on the Internet, consider reading a few of these vaccine books that are based on evidence, not fear.

More Information on Vaccine Books:

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Where are the Double Blind Placebo Controlled Randomized Trials about Vaccines

Have you ever heard that there are no double-blind, placebo-controlled randomized clinical trials for vaccines?

It isn’t true.

There are many double-blind, placebo-controlled randomized clinical trials that involved:

  • flu shots
  • pneumonia shots
  • HPV vaccines
  • potential HIV vaccines
  • malaria vaccines
  • rotavirus vaccines
  • Dengue vaccine
  • Staphylococcus aureus vaccine

That’s good, because double-blind, placebo-controlled randomized clinical trials are considered the “gold standard” when you do medical research.

“Placebo Control – A comparator in a vaccine trial that does not include the antigen under study. In studies of monovalent vaccines this may be an inert placebo (e.g. saline solution or the vehicle of the vaccine), or an antigenically different vaccine. In combined vaccines, this may be a control arm in which the component of the vaccine being studied is lacking.”

WHO on the Guidelines on clinical evaluation of vaccines: regulatory expectations

Tragically, many more folks got pneumonia and died if they got the saline placebo instead of the vaccine in this study.
Tragically, many more folks got pneumonia and died if they got the saline placebo instead of the vaccine in this study.

But do they all use a saline placebo?

No, not always, which typically leads anti-vaccine types to dismiss them outright and push anti-vaccine misinformation, including that they are never done.

It seems that they aren’t worried so much about the antigens in vaccines anymore (the Too Many, Too Soon argument), but are now more concerned about other vaccine ingredients. They will only be satisfied with a saline placebo, but they must miss the part about wanting the trial to be double-blinded, which gets harder to do if the placebo doesn’t look and “feel” like the vaccine.

And they miss the part that “not always” doesn’t mean never.

Gardasil is a good, recent example of a vaccine that had a double-blind, placebo-controlled (using a saline solution without an adjuvant) trial for safety.

Others vaccine trials use a saline control too, including efficacy and safety trials for a new recombinant, live, attenuated, tetravalent dengue vaccine (it worked and had a good safety profile), a malaria vaccine (a phase I dose escalation study), a universal flu vaccine, a Staphylococcus aureus vaccine, etc.

The Ethics of Placebo Use in Vaccine Trials

So why haven’t placebo control studies been done even more routinely then?

Why isn’t every vaccine on the immunization schedule or every combination of vaccines tested using a double-blind, placebo controlled study?

“Placebo use in vaccine trials is clearly acceptable when (a) no efficacious and safe vaccine exists and (b) the vaccine under consideration is intended to benefit the population in which the vaccine is to be tested.”

Placebo use in vaccine trials: Recommendations of a WHO expert panel

Of course, the answer is that in order to do this type of study, you would have to have a very good justification for leaving many of the kids unprotected and at risk for a vaccine-preventable disease.

Instead, as is discussed in the article “Current topics in research ethics in vaccine studies,” if a vaccine is “already in use in some other country or community which is more or less comparable to site where the trial is planned, that vaccine should be used as the comparator.”

So instead of a placebo, it is more common “to give another vaccine that provides comparable benefit against another disease, or more willingly, against similar disease caused by different agents.”

When can you use a placebo control?

The article states that “placebo controls are ethically acceptable when there is no proven vaccine for the indication for which the candidate vaccine is to be tested.”

But get educated and don’t be fooled, many double-blind, placebo-controlled randomized clinical trials have been done with vaccines.

What to Know About Placebo Use in Vaccine Trials

When it is ethical to do so, placebos have been used in vaccine trials, even saline placebos.

More on Placebo Use in Vaccine Trials