Tag: genotype

Are Deadly New Rogue Strains of Mutating Measles Spreading Like Wildfire?

Why do some folks think that deadly new rogue strains of measles are spreading like wildfire?

Mutating strains of measles are not spreading like wildfire.

The usual suspects, and this, a letter sent by Bobby Kennedy to the Prime Minister of Samoa during their deadly measles epidemic

Are Deadly New Rogue Strains of Mutating Measles Spreading Like Wildfire?

So is it true?

“Further analysis of the MeV-N gene sequences of these 2 groups confirmed that they represent clearly definable, sequence-divergent D4 subgenotypes, which we named subgenotypes D4.1 and D4.2. The subgenotype D4.1 MeVs were isolated predominantly in Kenya and Ethiopia, whereas the MAb-resistant subgenotype D4.2 MeVs were isolated predominantly in France and Great Britain, countries with higher vaccine coverage rates. Interestingly, D4.2 subgenotype viruses showed a trend toward diminished susceptibility to neutralization by human sera pooled from approximately 60 to 80 North American donors.”

Munoz-Alla et al on Antigenic Drift Defines a New D4 Subgenotype of Measles Virus.

Well, researchers have found these strains of measles virus.

But the thing is, it doesn’t mean that our current measles containing vaccines don’t protect against them. That becomes evident when you remember that most cases of measles are in people who aren’t vaccinated.

Anyway, far from Kennedy‘s claim that these strains are spreading like wildfire, D4 strains of measles make up a very small and decreasing percentage of global outbreaks!

Mutating strains of measles are not spreading like wildfire.

In fact, 95% of cases are now caused by B3 and D8 strains, not Kennedy‘s new rogue mutated strain.

“…it is critical that the Samoan Health Ministry determine, scientifically, if the outbreak was caused by inadequate vaccine coverage or alternately, by a defective vaccine.”

Bobby Kennedy

Like the rest of the world, we know why there is a rise of measles in Samoa.

It is because not enough people are vaccinated and protected.

It is not because measles vaccines failed to produce antibodies in vaccinated mothers.

It is not because of mutated measles.

And it is not because of vaccine strain measles.

“There is also the possibility that children who received the live measles virus during Samoa’s recent vaccination drive may have shed the virus and inadvertently infected vulnerable children. It is a regrettable possibility that these children are causalities of Merck’s vaccine. Alarmed CDC officials documented this emerging phenomenon during the measles outbreak in California in 2015. Federal epidemiological investigations found that at least 1/3 of Californian cases were vaccine strain. In fact, CDC identified 73 of the 194 measles virus sequences obtained across the entire United States in 2015 as vaccine strain A sequences. This means that those children contracted measles from vaccination or from someone who received the vaccine.”

Bobby Kennedy

There were no vaccine strain measles cases in California or anywhere else recently.

“I was dismayed—but not surprised—to see media reports that linked the current measles outbreak to the so-called ‘anti-vaccine’ movement.”

Bobby Kennedy

Are you surprised that Kennedy and others would exploit the tragedy in Samoa to scare parents away from vaccinating and protecting their kids and push their anti-vaccine agenda?

You shouldn’t be.

This is the modern anti-vaccine movement.

More on Mutating Strains of Measles

Jim Meehan Supporting a Farmer Helps Explain the Deaths in Samoa

In case you need to be caught up, there is a measles epidemic in Samoa and over 50 kids have already died.

While that easily dwarfs the number of deaths in many other countries, where there have been thousands of deaths, Samoa has been getting some extra attention because some of the blame rests with anti-vax influence on the island nation.

Taylor Winterstein compared the plan to vaccinate everyone against measles to stop the outbreak to Nazi Germany!

Samoa even got a visit from Bobby Kennedy last June!

Jim Meehan Supporting a Farmer Helps Explain the Deaths in Samoa

It is even more amazing that many of these folks have been doubling down on their anti-vax activism even as measles deaths have continued to climb.

Edwin Tamasese is an holistic healer in Samoa.
I wonder what Jim Meehan thinks caused those birth defects in Brazil…

It seems that Edwin Tamasese, a farmer in Samoa who is also described as a holistic healer, is being advised on how to treat kids with measles by James Meehan, an ophthalmologist in Oklahoma who now practices integrative and functional medicine.

How do either have the training or background to help sick kids in a measles epidemic?

That they don’t is easy to see from Meehan’s letter of support…

The last thing folks in Samoa need is advice from Jim Meehan!
The last thing folks in Samoa need is advice from Jim Meehan!

Wait, why would anyone vaccinate a child who was already infected with measles?

Probably because it is a part of routine measles postexposure prophylaxis guidelines. In fact, giving a dose of MMR within a few days of exposure to someone with measles can reduce their risk of getting sick with measles or of developing complications of measles.

Of course, you wouldn’t actually give the MMR vaccine to someone who was already sick with measles though. Instead of simply being infected with measles, that would be someone with measles disease.

Big difference!

Antibiotics don't treat viral infections, but they do treat secondary bacterial diseases and superinfections that often complicate measles infections.

There are no indications for antibiotics to treat uncomplicated viral diseases, unfortunately, secondary bacterial diseases can occur and do need to be treated.

“These results document that MV infection can suppress both innate and adaptive immune responses and lead to increased susceptibility to bacterial infection.”

Slifka et al on Measles virus infection results in suppression of both innate and adaptive immune responses to secondary bacterial infection

In fact, it is these secondary bacterial super-infections, including pneumonia and mastoiditis, that can make measles so deadly.

“Mortality from measles is predominantly caused by complicating bacterial infections.”

Factsheet about measles

It is a big reason that kids with measles, a viral infection, likely need to be treated with antibiotics.

It is typically only recommended that parents treat fever if their child is very uncomfortable.
It is typically only recommended that parents treat fever if their child is very uncomfortable.

Kids with measles typically have a high fever and are very irritable.

While we have been moving towards an approach of letting fevers run their course these days, in case fever does have some beneficial effects, there are also studies that have shown that in critically ill patients, fever is associated with increased mortality.

Measles is not mutating.
Mutating measles? Where have we heard that before?

Why do we genotype measles strains?

So that we know where outbreaks originated from.

Unlike some other infections, the genotype doesn’t help you figure out whether or not the vaccine will work against it. Measles is a monotypic virus. The MMR vaccine protects against all measles strains.

“The outbreaks in Samoa and Tonga are caused by the D8 strain (genotype) of measles virus.”

Measles Outbreak in the Pacific – Situation Report No 2, 26 November 2019

An no, for the millionth time, 38% of the measles cases in the Disneyland outbreak were not caused by the vaccine strain!

Those folks with the vaccine strain were the ones who were recently vaccinated and had a “febrile rash illness,” a common side effect of the vaccine.

They did not have measles!

While vaccinating someone who is truly immunosuppressed with a live vaccine is contraindicated, it seems like Meehan thinks that most of the folks on Samoa are immunosuppressed and shouldn’t be vaccinated!

The kids are dying because they aren't vaccinated and protected!
Not the measles virus??? The kids are dying because they aren’t vaccinated and protected!

There is a state of emergency in Samoa that has closed schools, banned public gatherings, and mandated vaccines, as they attempt to get their measles epidemic under control. They are also getting help from UNICEF, the New Zealand Red Cross, UK’s Emergency Medical Team (UK EMT), the Australian Medical Assistance Team (AUSMAT), and the New Zealand Medical Assistance Team (NZMAT).

More help is coming from the CDC and the EUCPM.

How much vitamin C are the kids on Tamasese's protocol getting?
How much vitamin C are these kids getting? 3000mg? 5000mg? Since too much vitamin C causes diarrhea and nausea, how much will they take “until stomach runs?” Diarrhea and dehydration are already complications of measles…

They do not need folks like Tamasese and Meehan interfering with these efforts because they think they can do it better, even as they scare parents away from vaccinating and protecting their kids – the one thing that will end the epidemic.

It should be noted that as much as anti-vax folks are crowing about Tamasese and Meehan’s efforts to get kids vitamin A, their protocol severely under doses kids!

The WHO has a protocol for giving kids high doses of vitamin A when they have measles.
The WHO has a protocol for giving kids high doses of vitamin A when they have measles.

Anyway, mega doses of vitamin A are most helpful in reducing mortality in hospitalized kids with measles. It is also important to keep in mind that vitamin A only reduces mortality – it doesn’t eliminate it. Vitamin A is not a cure for measles.

And the mega doses of vitamin C they are giving aren’t going to help prevent complications. They are just giving the kids diarrhea, which is not a good thing if they might already be malnourished!

What’s the biggest takeaway from the Samoa epidemic?

As we see more measles, we will see more people die with measles.

Measles is deadly.

This type of anti-vax propaganda is the reason that parents might think that vaccines are toxic...
This type of anti-vax propaganda is the reason that parents might think that vaccines are toxic…

Get vaccinated and protected with two doses of MMR and prevent these outbreaks.

More on Jim Meehan and Samoa

Are the Measles Outbreaks in New York a Hoax?

Wait, why do some folks think that the measles outbreaks in New York are a hoax?

There were no confirmed cases in the measles outbreaks in New York, except the 654 measles cases that were confirmed… Some hoax!
There were no confirmed cases in the measles outbreaks in New York, except the 654 measles cases that were confirmed… Some hoax!

Oh, the usual suspects

Are the Measles Outbreaks in New York a Hoax?

Brooklyn, New York had 654 measles cases in the largest measles outbreak in 27 years.

There have been 312 confirmed cases in the measles outbreaks in Rockland, County, New York.

There have been an additional 312 confirmed, reported cases in Rockland County, New York, the longest measles outbreak since the endemic spread of measles was declared eliminated in 2000.

Were they a hoax?

“A total of 654 cases were confirmed, with rash onsets between September 30, 2018 and July 15, 2019. Serious complications included hospitalization (52), intensive unit care (19) and pneumonia (34). Multiple international importations of measles introduced into a community with prevalent delays in vaccination among young children propagated this outbreak.”

2019 Health Alert #26: Update on Measles Outbreak in New York City

Of course not!

The New York State Department of Health advises that on all suspected measles cases, “Viral specimens (nasopharyngeal swaband urine) and serology (IgM and IgG) should be obtained for diagnostic testing and confirmation.”

Were these cases all caused by vaccine strain measles, as Larry Palevesky suggests?

Of course not!

A vaccine strain has never before caused a measles outbreak. And NYC Health Commissioner Dr. Oxiris Barbot, in a press conference, stated that “Yeah, it’s, you can’t get the measles from the vaccine.”

Although anti-vax folks often focus on the measles strain when there is an outbreak, all it really helps you do is figure out where the imported cases came from.

Even though health officials didn’t tell us the specific strains involved in the outbreaks, guess what, they did tell us the sources of the outbreak, so it is basically the same thing.

The cases were imported from Israel, UK, and Ukraine.

And the CDC has told us that “All measles cases this year have been caused by measles wild-type D8 or B3.”

“We have to stop blaming, accusing, targeting, ostracizing, condemning unvaccinated children as a health risk, which would then make this subject completely moot.”

Larry Palevsky

What else do we know about the measles outbreak in Brooklyn?

  • it began in October 2018 “with an unvaccinated child from Brooklyn who acquired measles in Israel”
  • it included 15 neighborhoods in Brooklyn, with most concentrated in Williamsburg, Borough Park, and Sunset Park
  • the majority of cases were in children, including at least 91 cases in infants less than 12 months old
  • the great majority of cases were unvaccinated, with only 27 cases fully vaccinated with two doses of MMR
  • there were 52 hospitalizations, including 16 ICU admissions

And the outbreak cost over $6 million to control!

The Rockland County measles outbreak ended in late September and is also said to have cost over $6 million to control.

At a gathering for the New York Alliance for Vaccine Rights and First Freedoms Community, these folks, including Larry Palevsky (left) are discussing the "alleged" measles outbreaks that New York spent $6 million and 500 staff to contain.
At a gathering for the New York Alliance for Vaccine Rights and First Freedoms Community, these folks, including Larry Palevsky (left) are discussing the “alleged” measles outbreaks that New York spent $6 million and 500 staff to contain.

So why do they think they are a hoax?

“There were over 800 kids who the New York State and New York City Department of Health have said were confirmed cases of measles. The real question is, were these really confirmed as per the CDC recommendations. We do not have that data. In fact, anecdotally, New York State told the physicians not to do the tests.”

Larry Palevsky

Is this about the strains again? Is this about the fact that once you know you are in the middle of a huge measles outbreak, you might be able to start diagnosing kids clinically?

“New York State lied when they said that there were confirmed cases. We don’t know what kind of illnesses the kids had. And there’s a set of papers in the literature that specifically state that if the children are found by analysis to have a measles virus infection that is consistent with a side effect of the vaccine, it is important for the Department of Health to alert the public that it was a vaccine strain that caused the outbreak, because a vaccine strain illness should not be equated with a public health emergency. [Applause]”

Larry Palevsky

Yes, it is about the strains…

“So the reality is that when there is a vaccine strain measles outbreak, meaning that the vaccine itself was not properly attenuated, meaning it was more active and virulent than just simply giving an antibody response in the body, when that occurs an outbreak is almost always very very close to the vest, meaning that would explain why it was only seen in two communities out of 62. And if New York state had done the proper testing of the vaccine to see if it was too virulent and of the children who had the measles infection to see what type of measles virus they had, then in all likelihood this was a vaccine strain measles infection which is known to be a side effect of the vaccine and not a public health emergency.”

Larry Palevsky

Is any of that true?

Since we have never had an outbreak of measles from an MMR vaccine that wasn’t properly attenuated, I’m guessing no, it isn’t. Also remember that to control the outbreak, they gave lots and lots of MMR vaccine to unvaccinated folks in those communities…

What about his explanation for why we only saw outbreaks in Brooklyn and Rockland Counties? Well, for one thing, we didn’t. Other areas of New York and of course, around the country have seen a rise in measles. And the outbreaks in Brooklyn and Rockland Counties were caused when unvaccinated folks traveled to Israel, UK, and Ukraine and returned to an area with low immunization rates. They weren’t caused by a bad batch or mutant strains of measles in the MMR vaccine.

“So the New York State Department of Health failed to do their job and instead they lied and said the cases were confirmed and they didn’t do their due diligence to actually evaluate all the possible reasons that an outbreak could have occurred. It’s very strange that two communities where there are lots of people moving through those communities that are non-Jewish, that are outside of the state that are coming through and why just those communities got the illness. That should have raised the red flag that something else was going on and your state failed us.”

Is it possible that those other people moving in and out of those communities in Brooklyn and Rockland County were vaccinated and protected against measles?!?

One thing should be very clear.

Brooklyn may have stopped their measles outbreak, but New York still has a public health emergency on their hands.

Well, not just New York. We need to stop this kind of propaganda if we want to keep parents from being scared to immunize and protect their kids.

More on Measles in NY

Should I Blame the Vaccine If I’m Sick and I Just Got Vaccinated?

We all know the saying, correlation equals causation, right?

So if you get an MMR vaccine and get the measles a week later, it has to be the vaccine, right?

Should I Blame the Vaccine If I’m Sick and I Just Got Vaccinated?

Actually, no.

“Correlation does not imply causation.”

Although it would be very easy to blame the vaccine, if you keep in mind that the saying is actually “correlation does not imply causation,” maybe you will do a little investigating and see if something else is to blame.

Some things to consider and ask yourself:

  1. Do I really have measles? Remember that it is not uncommon to develop a fever and a rash about 7 to 12 days after getting an MMR vaccine. This is a very common, mild vaccine reaction. It doesn’t mean that you have measles or even a mild case of the measles.
  2. Was I recently exposed to someone with measles? If you were vaccinated because you were exposed to measles during an outbreak, then there is a good chance that the vaccine hasn’t had a chance to work yet and you actually developed measles from being exposed to the wild virus.
  3. Do I have the wild type or a vaccine strain of measles? Testing can be done to tell which strain of measles you have and to see if it is a wild type or vaccine strain.

Are there any examples of folks having wild type disease if they get sick shortly after being vaccinated?

Not surprisingly, there are a lot of these types of examples.

“Vaccine strains are poorly or not transmissible and prompt differentiation between wild-type and vaccine strains allows for optimal management and public health action.”

Pabbaraju et al on Simultaneous Detection and Differentiation between Wild-Type and Vaccine Measles Viruses by a Multiplex Real-Time Reverse Transcription-PCR Assay

What about examples of folks getting sick with vaccine strain measles and other diseases? Not so many.

The clinical diagnosis could just as easily have been wild type measles and not a vaccine strain, as there was a lot of measles in the the UK in 1988.
The clinical diagnosis could just as easily have been wild type measles, as there was a lot of measles in the the UK in 1988.

Most of the published examples are case reports without evidence of a vaccine strain.

What about the kid in Canada that got measles after her MMR vaccine?

“We describe a case of vaccine-associated measles in a two-year-old patient from British Columbia, Canada, in October 2013, who received her first dose of measles-containing vaccine 37 days prior to onset of prodromal symptoms.”

Murti et al on Case of vaccine-associated measles five weeks post-immunisation, British Columbia, Canada, October 2013.

She had symptoms of measles and a vaccine strain and was reported as “the first case of MMR vaccine-associated measles.” Well, at least the first case that occurred so long after getting vaccinated. Still, they note that “clinically significant vaccine-associated illness is rare.”

What about all of the people in California and Michigan who supposedly had vaccine-strain measles?

This is not vaccine strain measles! It is people with a rash or fever after being vaccinated. They don't have measles though.
This is not vaccine strain measles! It is people with a rash or fever after being vaccinated. They don’t have measles though.

Anti-vaccine folks made that up!

When It’s a Wild-Type Virus

What’s the most obvious evidence against the idea that vaccines and shedding are responsible for causing outbreaks?

For one thing, despite the recent uptick, cases of vaccine-preventable diseases are way down from the pre-vaccine era. That’s not what you would expect if vaccine-induced disease was common or if contacts of those who were recently vaccinated could easily get sick from shedding.

And we have evidence against vaccine induced disease.

When kids get chicken pox shortly after being vaccinated, they often have a wild strain. They don’t have breakthrough chicken pox.

“All of 57 vaccinees with breakthrough varicella, clinically diagnosed on the basis of a generalized maculopapular or vesicular rash, in which there was amplifiable DNA [corrected], had wild-type VZV infection based on analysis of viral DNA. “

LaRussa on Viral strain identification in varicella vaccinees with disseminated rashes.

Same thing with measles.

Want to avoid these situations in which you could get a wild strain of a vaccine-preventable disease?

Don’t skip or delay your child’s vaccines!

More On Wild-Type and Vaccine Measles Viruses