Tag: vaccine strains

Should I Blame the Vaccine If I’m Sick and I Just Got Vaccinated?

We all know the saying, correlation equals causation, right?

So if you get an MMR vaccine and get the measles a week later, it has to be the vaccine, right?

Should I Blame the Vaccine If I’m Sick and I Just Got Vaccinated?

Actually, no.

“Correlation does not imply causation.”

Although it would be very easy to blame the vaccine, if you keep in mind that the saying is actually “correlation does not imply causation,” maybe you will do a little investigating and see if something else is to blame.

Some things to consider and ask yourself:

  1. Do I really have measles? Remember that it is not uncommon to develop a fever and a rash about 7 to 12 days after getting an MMR vaccine. This is a very common, mild vaccine reaction. It doesn’t mean that you have measles or even a mild case of the measles.
  2. Was I recently exposed to someone with measles? If you were vaccinated because you were exposed to measles during an outbreak, then there is a good chance that the vaccine hasn’t had a chance to work yet and you actually developed measles from being exposed to the wild virus.
  3. Do I have the wild type or a vaccine strain of measles? Testing can be done to tell which strain of measles you have and to see if it is a wild type or vaccine strain.

Are there any examples of folks having wild type disease if they get sick shortly after being vaccinated?

Not surprisingly, there are a lot of these types of examples.

“Vaccine strains are poorly or not transmissible and prompt differentiation between wild-type and vaccine strains allows for optimal management and public health action.”

Pabbaraju et al on Simultaneous Detection and Differentiation between Wild-Type and Vaccine Measles Viruses by a Multiplex Real-Time Reverse Transcription-PCR Assay

What about examples of folks getting sick with vaccine strain measles and other diseases? Not so many.

The clinical diagnosis could just as easily have been wild type measles and not a vaccine strain, as there was a lot of measles in the the UK in 1988.
The clinical diagnosis could just as easily have been wild type measles, as there was a lot of measles in the the UK in 1988.

Most of the published examples are case reports without evidence of a vaccine strain.

What about the kid in Canada that got measles after her MMR vaccine?

“We describe a case of vaccine-associated measles in a two-year-old patient from British Columbia, Canada, in October 2013, who received her first dose of measles-containing vaccine 37 days prior to onset of prodromal symptoms.”

Murti et al on Case of vaccine-associated measles five weeks post-immunisation, British Columbia, Canada, October 2013.

She had symptoms of measles and a vaccine strain and was reported as “the first case of MMR vaccine-associated measles.” Well, at least the first case that occurred so long after getting vaccinated. Still, they note that “clinically significant vaccine-associated illness is rare.”

What about all of the people in California and Michigan who supposedly had vaccine-strain measles?

This is not vaccine strain measles! It is people with a rash or fever after being vaccinated. They don't have measles though.
This is not vaccine strain measles! It is people with a rash or fever after being vaccinated. They don’t have measles though.

Anti-vaccine folks made that up!

When It’s a Wild-Type Virus

What’s the most obvious evidence against the idea that vaccines and shedding are responsible for causing outbreaks?

For one thing, despite the recent uptick, cases of vaccine-preventable diseases are way down from the pre-vaccine era. That’s not what you would expect if vaccine-induced disease was common or if contacts of those who were recently vaccinated could easily get sick from shedding.

And we have evidence against vaccine induced disease.

When kids get chicken pox shortly after being vaccinated, they often have a wild strain. They don’t have breakthrough chicken pox.

“All of 57 vaccinees with breakthrough varicella, clinically diagnosed on the basis of a generalized maculopapular or vesicular rash, in which there was amplifiable DNA [corrected], had wild-type VZV infection based on analysis of viral DNA. “

LaRussa on Viral strain identification in varicella vaccinees with disseminated rashes.

Same thing with measles.

Want to avoid these situations in which you could get a wild strain of a vaccine-preventable disease?

Don’t skip or delay your child’s vaccines!

More On Wild-Type and Vaccine Measles Viruses

Are Mutant Strains of Polio Vaccine Now Causing More Paralysis Than Wild Polio?

Believe it or not, it’s true.

Mutant strains of polio vaccine have been causing more paralysis than wild polio.

Are Mutant Strains of Polio Vaccine Now Causing More Paralysis Than Wild Polio?

Although anti-vaccine folks seem to be having a field day over the news, it doesn’t really mean what they think it means.

It isn’t even true anymore…

Not getting polio is a good thing. A pediatrician, especially one who wrote a vaccine book should understand the benefits of the polio vaccine.

The article Bob Sears shared isn’t even current…

“So far in 2017, there have been only six cases of “wild” polio reported anywhere in the world. By “wild,” public health officials mean the disease caused by polio virus found naturally in the environment.

By contrast, there have been 21 cases of vaccine-derived polio this year.”

Mutant Strains Of Polio Vaccine Now Cause More Paralysis Than Wild Polio

It was from two years ago.

There were only 22 cases of wild polio in the world in 2017. We are on track for many more cases this year.
There were only 22 cases of wild polio in the world in 2017. We are on track for many more cases this year.

He doesn’t even mention the main reason that mutant strains of polio vaccine are now causing more paralysis than wild polio.

“Global efforts to immunise children with the oral polio vaccine (OPV) have reduced wild poliovirus cases by 99.9% since 1988.”

Fact Sheet: Vaccine-Derived Poliovirus

And that is simply because most people are vaccinated and protected and we are very close to eradicating polio!

“As recently as 30 years ago, wild poliovirus paralysed more than 350,000 children in more than 125 countries every year. In 2018 there were fewer than 30 reported cases in just two countries – Afghanistan and Pakistan.”

“Zero polio transmission and health for all”, WHO Director-General gives new year’s wish to the people of Afghanistan and Pakistan

Nor does he mention that vaccine derived polio virus strains mutate when too many people are unvaccinated.

What else does Bob Sears leave out of his post?

Polio this week as of 24 July 2019, with more paralysis from wild polio viruses than mutant strains of the polio vaccine.
Polio this week as of 24 July 2019, with more paralysis from wild polio viruses than mutant strains of the polio vaccine.

So far, this year, we are tragically seeing more paralysis from wild polio than mutant strains of the polio vaccine!

What’s the last thing Bob Sears left out of his post?

Most of the “mutant strains” of polio vaccine are from the type 2 vaccine virus, which isn’t being used anymore. In 2016, all countries switched to bivalent OPV, which doesn’t include the type 2 polio virus strain.

And since most cases of wild polio are in just a few countries, namely Pakistan and Afghanistan, we will hopefully get back on track to eradication and also see a drop in paralysis from the mutant vaccine strains. That’s when we can stop using the oral polio vaccine all together.

At least we will if folks stop listening to anti-vaccine misinformation and propaganda that scares them away from vaccinating and protecting their kids.

More On Paralysis from Mutant Strains of Polio Vaccine Vs Wild Polio

Was the Measles Outbreak in Michigan Caused by Vaccine-Strain Measles?

Anti-vaccine folks are pushing some new misinformation about measles outbreaks.

Was the Measles Outbreak in Michigan Caused by Vaccine-Strain Measles?

What is it this time?

The Michigan measles outbreak was not caused by a vaccine strain of measles.
The Michigan measles outbreak was not caused by a vaccine strain of measles.

Vaccine-strain measles?

Causing an outbreak?!?

Since a vaccine-strain has never triggered an outbreak before, you would think these folks would be a little more skeptical about this “news.”

So what’s the real story?

“The Michigan Department of Health and Human Services (MDHHS) is reducing the statewide count of measles for 2019 to 39 following further testing of two of the cases.”

State measles cases reduced to 39 following additional testing

So there is a hint of truth to their new rumor…

“One child in Washtenaw County had been potentially exposed to measles and that child, along with an Oakland County child, had both been recently vaccinated. Their symptoms and initial test results classified them as measles cases. Per the Centers for Disease Control and Prevention (CDC) protocol, additional genotype testing was conducted and determined they were not measles cases. “

State measles cases reduced to 39 following additional testing

On further testing though, they didn’t have wild strain measles. They had a vaccine strain – because they had recently been vaccinated.

These two kids likely had a fever and rash and because they had recently been exposed to measles, it was initially assumed that they had measles. That was likely a safe bet in the middle of a large measles outbreak.

But as often seems to happen, anti-vaccine folks get confused by vaccine reactions and vaccine associated measles.

So they didn’t have measles induced by the vaccine. They had a simple vaccine reaction, with a fever and rash.

What’s the difference? All of the other symptoms of measles!

The Southeast Michigan outbreak, which included 44 cases, began in mid-March.
The Southeast Michigan outbreak, which included 44 cases, began in mid-March.

As ridiculous as it is to have to say this, the Michigan measles outbreak was not canceled. And like other outbreaks, the Michigan measles outbreak was not caused by a vaccine or shedding.

More on the Michigan Measles Outbreak

Vaccine Schedules from the 1940s to 2019

To scare parents away from vaccinating and protecting their kids, anti-vaccine folks continue to push the idea the kids get too many vaccines at too early an age.

They don’t.

When did we have a vaccine schedule when we gave just two vaccines?
When did we have a vaccine schedule when we gave just two vaccines?

They try to reinforce the idea by comparing things to the “good ol’ days,” when they think kids only got one dose of one or two vaccines.

Did they?

Vaccine Schedules from the 1940s to 2019

Let’s take a look at how the vaccine schedule has evolved over time to see how many vaccines kids used to get. Looking at the old vaccine schedules can also help you understand how we got to our current schedule.

Although not a formal schedule, the first vaccine recommendations were published in the AAP’s Special Committee on Prophylactic Procedures Against Communicable Diseases 1938 pamphlet, Routine measures for the prophylaxis of communicable diseases.

It included vaccines against diphtheria, pertussis, rabies, tetanus, tuberculosis, typhoid fever, and smallpox.

A schedule of immunizations from a 1948 AAP Round Table Discussion on the Practical and Immunological Aspects of Pediatric Immunizations
A schedule of immunizations from a 1948 AAP Round Table Discussion on the Practical and Immunological Aspects of Pediatric Immunizations

That’s the schedule from 1948!

Surprised?

Many of you were led to believe that kids only got 2 vaccines back in the day. Instead, they got more vaccines and multiple doses of those vaccines.

Multiple doses with formaldehyde inactivated vaccines which contained aluminum. And thimerosal. And far more antigens than kids are exposed to today, even though they now get many more vaccines.

My uncle got polio around the time this vaccine schedule was released in 1951, but before the first polio vaccines were being routinely used.
My uncle got polio around the time this vaccine schedule was released in 1951, but before the first polio vaccines were being routinely used.

By the early 1950s, the DPT vaccine became routine. Other vaccines were also available for special situations, including rabies, typhoid, parathyphoid, and the BCG vaccine.

And of course, we got the polio shot in 1955!

Kids got multiple doses of DPT, DT, polio, and smallpox vaccines in 1960.
Kids got multiple doses of DPT, DT, polio, and smallpox vaccines in 1960.

Although few people remember, the original polio vaccines were monovalent and only included one polio strain in each shot. So you had to get multiple shots to get protected from all three strains!

The polio shot, was used until 1962, when we switched to the oral polio vaccine. Trivalent OPV wasn’t licensed until 1963 though. Before that, kids got multiple doses of monovalent OPV, types 1, 2, and 3.

The ACIP committee came up with four different dosage schedules for measles vaccines in 1964.
The ACIP committee came up with four different dosage schedules for measles vaccines in 1964.

And for a few years, we had both inactivated and live measles vaccines…

The recommended immunization schedule by the AAP in the 1966 Red Book. The first measles vaccine was approved in 1963.

Next came the individual mumps (1967) and rubella (1969) vaccines and the combination MMR vaccine (1971).

And the end of routine vaccination with the smallpox vaccine (1972).

Eleven doses of four vaccines protected kids against seven vaccine-preventable diseases in 1983.
Eleven doses of four vaccines protected kids against seven vaccine-preventable diseases in 1983.

The Hib vaccine was added in 1985.

Twelve doses of five vaccines protected kids against eight vaccine-preventable diseases in 1989.
Twelve doses of five vaccines protected kids against eight vaccine-preventable diseases in 1989.

Next came the hepatitis B vaccine and expanded age ranges for the Hib vaccine.

Seventeen doses of five vaccines protected kids against eight vaccine-preventable diseases in 1989 (plus the later Td booster).
Nineteen doses of six vaccines protected kids against nine vaccine-preventable diseases in 1995.

What’s still missing?

Vaccines and protection against rotavirus, hepatitis A, chicken pox, flu, pneumococcal bacteria, meningococcal bacteria, and HPV. And no, they weren’t all added right after the National Childhood Vaccine Injury Act of 1986, another anti-vaccine myth!

Those vaccines were added to the schedule much later:

  • Varivax – a chickenpox vaccine (1995)
  • the polio shot – we began to switch back in 1996
  • VAQTA – the first hepatitis A vaccine was approved for high risk kids in 1996, but wasn’t actually added to the routine vaccine schedule until 2006
This is the immunization we used when I finished residency...
This is the immunization we used when I finished residency…

RotaShield, the first rotavirus vaccine was approved in 1998 but was quickly withdrawn in 1999 because of an increased risk of intussusception

What’s next?

  • Prevnar, with protection against pneumococcal bacteria (2000)
  • FluMist – the nasal spray flu vaccine (2004)
  • new flu shots recommendations for all healthy infants (2004)

Is the vaccine schedule starting to look familiar?

RotaTeq and Gardasil were added to the vaccine schedule the next year, in 2007.
RotaTeq and Gardasil were added to the vaccine schedule the next year, in 2007.

Since then, Prevnar was updated to include protection against 13 strains of pneumococcal bacteria. And we got a new vaccine that covers the B strain of meningococcal disease, but otherwise there haven’t been any major changes to the vaccine schedule in a while.

The 2019 vaccine schedule.
The 2019 vaccine schedule.

Do you see 72 vaccines on the schedule?

Kids today routinely get 13 vaccines that protect them 16 vaccine-preventable diseases.

Do you see 72 doses of vaccines on the schedule?

Guess what? These folks are deliberately misleading you.
Guess what? These folks are deliberately misleading you.

Kids don’t get 72 doses of vaccines today.

That’s an inflated number that’s used to scare parents. That it is a propaganda technique should be obvious, as the folks who use it don’t use the same anti-vaccine math to inflate the number of doses from the historical schedules.

More on Vaccine Schedules from the 1940s to 2019