Titers for Vaccine vs Natural Immunity

It probably seems like a silly question, but can titers help you tell the difference between vaccine induced vs natural immunity?

After all, you should know if you had the disease naturally or if you had a vaccine, right?

Titers for Vaccine vs Natural Immunity

Still, there might be situations in which you need to know if someone has immunity and you want to know if it was vaccine induced or if they earned their immunity naturally.

Unfortunately, you typically can’t, especially as most vaccines mimic having a natural infection.

In a few situations, if a vaccine targets a very specific part of a virus or bacteria, it may be able possible to tell the difference between vaccine-induced and natural immunity though.

anti-HBs is positive with natural infections and vaccination, but only anti-HBc is positive after a natural infection.

The hepatitis B vaccine, for example, is derived from HBsAg particles, so won’t induce antibodies against hepatitis B core antigen or other hepatitis B proteins.

Most other vaccines, like MMR and Varicella, aren’t so specific. Titers might just show that you are immune, although titer tests aren’t always sensitive enough to pick up vaccine-induced immunity. That’s why, expect for a few high risk situations, titer testing isn’t usually recommended.

More on Titers for Vaccine vs Natural Immunity

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