Tag: variolation

Did Edward Jenner’s Son Die from a Vaccine Reaction?

Maybe people know that Edward Jenner first gave his new smallpox vaccine to James Phipps, the 8-year-old son of Jenner’s gardener.

What they might now know is that two years later, in 1798, he also vaccinated his own son Robert F. Jenner, when he was eleven months old.

Did Edward Jenner’s Son Die from a Vaccine Reaction?

Did he die after getting vaccinated?

Did he suffer brain damage?

Of course not!

Edward Jenner vaccinated his youngest son, Robert.
Edward Jenner vaccinated his youngest son, Robert.

He didn’t even have a reaction and was later inoculated after being exposed to smallpox.

“My two eldest children were inoculated for the smallpox before I began to inoculate for the cow-pox. My youngest child was born about the time my experiments commenced, and was among the earliest I ever vaccinated. By referring to the first work I published on the subject in the spring of the year 1798, page 40, you will find his name, Robert F. Jenner, and you will observe it noticed that on his arm the vaccine lymph did not prove infectious. It advanced two or three days, and then died away.”

Edward Jenner on the Life of Dr. Jenner

He died 56 years later.

Edward Jenner’s other children didn’t receive his smallpox vaccine. As they were all born before his experiments with cowpox, they had already received traditional smallpox inoculations.

“Edward is growing tall, and has long looked over my head. Catherine, now eleven years old, is a promising girl; and Robert, eight years old, is just a chip of the old block.”

Edward Jenner on the Life of Dr. Jenner

Edward Robert Jenner did die young, but it certainly wasn’t an effect of his father’s smallpox vaccine. He died of tuberculosis, which was a common killer at the time. He was 21 and had always had health problems, but again, he never received his father’s new vaccine, so how could he be the “first child to suffer vaccine damage???”

This myth is easy to debunk. Jenner's son that died young was never vaccinated!
This myth is easy to debunk. Jenner’s son, Edward, that died young was never vaccinated!

What about the ethical implications of giving an experimental vaccine to your own child? A vaccine made with cow pus?

Remember, Jenner’s smallpox vaccine was made with cowpox virus. It was replacing variolation, a procedure in which people were actually inoculated with smallpox virus. While much better than getting smallpox, variolation was still dangerous and some people died from the procedure.

His smallpox vaccine was a much safer option.

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Vaccines and Mother’s Day

Last year, we found several connections between Father’s Day and vaccines, especially that Maurice Hilleman has often been called the father of modern vaccines.

Is there a mother of modern vaccines?

Vaccines and Mother’s Day

Does it have to be modern vaccines?

Of course, the first person that comes to mind is Lady Mary Wortley Montagu, who learned about smallpox inoculation in Turkey and used it to protect her own children, also advocating for more general use in England.

But that involved variolation, not vaccination.

So who could be the mother of vaccines?

How about the person who “has done more for immunizations that any one person in this whole country?”

Betty Bumpers was a champion in our efforts to reduce the burden of vaccine-preventable diseases among children in the United States.  She played a major leadership role as 1st Lady of Arkansas in improving immunization in that state and was inspirational in launching the first major Presidential Initiative on Immunization during the late 1970s.  She continued to be a major immunization advocate through much of her life launching “Every Child By Two (ECBT)” which she chaired along with Mrs. Rosalyn Carter, now “Vaccinate Your Family”.

Walter Orenstein

And to honor her, let’s continue her work

Before vaccines, this mother and all of her kids got polio...
Before vaccines, this mother and all of her kids got polio…

For as Betty Bumpers said, “only when every child has completed his or her series of immunizations will our job be completed.”

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What Did Benjamin Franklin Say About Vaccines?

Wait, we had vaccines when Ben Franklin was around?

You can learn what Benjamin Franklin thought about vaccines from his autobiography.
You can learn what Benjamin Franklin thought about vaccines from his autobiography.

That was a long time ago.

What Did Benjamin Franklin Say About Vaccines?

Well, we had variolation

“Those who would give up essential Liberty, to purchase a little temporary Safety, deserve neither Liberty nor Safety.”

Benjamin Franklin

The Benjamin Franklin quote many anti-vaccine folks are using these days (do anti-vaccine folks get daily talking points to use?) doesn’t really have anything to do with vaccines though, at least not in the way that they think it does.

“The Franklin quote he nodded to on Tuesday, ironically, means the opposite of what Paul was arguing. When Franklin said, “Those who would give up essential Liberty, to purchase a little temporary Safety, deserve neither Liberty nor Safety,” he was opposing the Penn family’s attempt to carve out an exception for themselves from the Pennsylvania General Assembly’s attempt to tax their lands for the collective good of frontier defense. The liberty Franklin was defending was the liberty the rest of us deserve now, too — liberty to choose to protect ourselves.”

Saad B Omer on Rand Paul is wrong: Vaccines are no threat to liberty

It should be clear that Ben Franklin’s quote shouldn’t be used to attack vaccine mandates. If anything, it can be used to attack free-riders and those who skip or delay vaccines and try to hide in the herd!

“It is a quotation that defends the authority of a legislature to govern in the interests of collective security. It means, in context, not quite the opposite of what it’s almost always quoted as saying but much closer to the opposite than to the thing that people think it means.”

Benjamin Wittes onBen Franklin’s Famous ‘Liberty, Safety’ Quote Lost Its Context In 21st Century

Interestingly, Benjamin Franklin did famously talk about vaccines, or at least smallpox variolation.

“In 1736 I lost one of my sons, a fine boy of four years old, by the small-pox, taken in the common way. I long regretted bitterly, and still regret that I had not given it to him by inoculation. This I mention for the sake of parents who omit that operation, on the supposition that they should never forgive themselves if a child died under it; my example showing that the regret may be the same either way, and that, therefore, the safer should be chosen.”

Benjamin Franklin

He got a little temporary safety, avoiding the side effects of variolation, but what were the consequences? What did he lose?

What do you lose when you make decisions about vaccines based on vaccine misinformation?

What do folks like Rand Paul have to gain by speaking out against vaccines?

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What Is a Vaccine?

You know what a vaccine is, right?

The word vaccine comes from the vaccinia virus that was in the original smallpox vaccine.
The word vaccine comes from the vaccinia virus that was in the original smallpox vaccine.

The flu shot you get each year is a vaccine.

Vaccine: A product that stimulates a person’s immune system to produce immunity to a specific disease, protecting the person from that disease. Vaccines are usually administered through needle injections, but can also be administered by mouth or sprayed into the nose.

Immunization: The Basics

The smallpox shot that Edward Jenner developed was a vaccine.

Vaccine Definitions

While that is an easy enough definition to understand, that there are many different types of vaccines does make it a little more complicated.

There are:

  • Live-attenuated vaccines – made from a weakened or attenuated form of a virus or bacteria
  • Inactivated vaccines – made from a killed form of virus or bacteria
  • Subunit, recombinant, polysaccharide, and conjugate vaccines – made from only specific pieces of a virus or bacteria
  • Toxoid vaccines – made to target a toxin that a bacteria makes and not the bacteria itself

And of course all of these types of vaccines work to produce immunity to specific diseases – vaccination.

Immunization: A process by which a person becomes protected against a disease through vaccination. This term is often used interchangeably with vaccination or inoculation.

Immunization: The Basics

What other definitions are important to know when you talk about vaccines?

  • active immunity – immunity that you get from having a disease (natural immunity) or getting a vaccine and making antibodies
  • adjuvant – a substance that helps boost your body’s immune response to a vaccine so that you can use a minimum amount of antigen, reducing side effects
  • antibodies – protective proteins that you make against antigens
  • antigens – specific substances (can be part of a virus or bacteria) that trigger an immune response
  • attenuation – a virus or bacteria that is made less potent, so that it can produce an immune response without causing disease
  • elimination – getting rid of a disease in a specific area
  • endemic – the baseline level of disease in an area
  • eradication – getting rid of a disease everywhere (smallpox)
  • epidemic – an increase in the number of cases of a disease over a large geographic area
  • herd immunity – when enough people in a community are protected and have immunity, so that disease is unlikely to spread
  • immunity – protection against a disease
  • incubation period – how long it takes to develop symptoms after you are exposed to a disease
  • outbreak – an increase in the number of cases of a disease over a small geographic area
  • pandemic – an increase in the number of cases of a disease over several countries or continents
  • passive immunity – temporary immunity that you get after being given antibodies, either via a shot of immunoglobulin or a mother’s antibodies are transferred to her baby through her placenta
  • placebo – classically defined as “a comparator in a vaccine trial that does not include the antigen under study”
  • quarantine – isolating someone so that they don’t get others sick
  • titer – an antibody count that can often be used to predict immunity

Got all of that?

So what about variolation, the process that was used before Jenner developed his smallpox vaccine? Was that also a vaccine?

It did produce immunity to smallpox, which is the basic definition of a vaccine, but still, variolation is typically concerned an immunization technique and not a vaccine.

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