Tag: mutations

Who Is Larry Palevsky?

Think you know all of the anti-vaccine pediatricians?

“The pediatrician who spoke on Monday night, Dr. Lawrence Palevsky, is regularly cited in pamphlets circulated in New York City that urge women not to get their children vaccinated. His views have no basis in science, experts said.”

Despite Measles Warnings, Anti-Vaccine Rally Draws Hundreds of Ultra-Orthodox Jews

Sadly, there is more than one pediatrician pandering to parent’s fears about vaccines these days.

Who Is Larry Palevsky?

Although not as well known as Sears or Thomas, who were thrown into the spotlight because they wrote anti-vaccine books and were associated with measles outbreaks in their areas, it would be hard to say what makes Palevsky different from any other anti-vaccine expert.

A holistic pediatrician, he was an “expert” for the anti-vaccination movie The Greater Good. Palevsky also often links to and quotes other notorious anti-vax “experts.”

He even appeared on the Gary Null Show – in addition to being anti-vax, Gary Null is among the alternative medicine folks who actually denies that HIV causes AIDS.

So no one should be surprised that Palevsky spoke at an anti-vaccine rally during the longest measles outbreak we have had in the United States in over 25 years. An ongoing measles outbreak that health officials are still struggling to contain.

At the rally, he talked at length about mutating viruses and falsely claimed that failed vaccines were producing a new strain of measles. Women scribbled into notepads as he spoke. Others filmed his comments, sending them to their contacts on WhatsApp. Essentially, he said, there were no studies available to show how the vaccine affects the human body.

“Is it possible that the measles-mumps-rubella vaccine that is somehow being given in this lot to communities in Williamsburg and Lakewood and Monsey, maybe in Borough Park, is it possible that these lots are bad?” he asked, referring to areas in New York and New Jersey with large ultra-Orthodox Jewish communities.

“It’s fascinating because we’re told how contagious the disease is, but somehow it’s centered in the Jewish community.”

Despite Measles Warnings, Anti-Vaccine Rally Draws Hundreds of Ultra-Orthodox Jews

It’s fascinating that a pediatrician would actually think that any of this is possible

Bad lots of vaccines?

Does Palevsky, who runs a Wellness Center, realize that only about 3-4% of the people who have gotten measles in Brooklyn and Rockland County have been fully vaccinated. Most are unvaccinated.

How does that fit into Palevsky’s theories about bad lots, mutating measles viruses, and failed vaccines?

Since Palevsky doesn’t seem to believe in the germ theory of disease, that viruses and bacteria can actually cause us to get sick, it isn’t hard to figure out. For him, of course, it would be easier to blame vaccines instead of the measles virus, I guess even vaccines that these folks have never received.

Sure. It is anything and everything except the fact that parents are intentionally not vaccinating and protecting their kids…

What’s really fascinating is that people are still listening to this kind of misinformation when they can see the consequences of what happens when they leave their community unvaccinated and unprotected.

“I believe in what’s called a starvation diet for kids when they’re sick.”

Larry Palevsky

And that they are listening to it from folks like Palevsky!

“Most of the reason that kids get sick is to move or get rid of wastes anyway.”

Larry Palevsky

But just in case they don’t get better by just removing the wastes in their body or by using supplements, essential oils or herbs and reducing their stress levels, Palevsky is very happy to refer your child to one of the homeopaths, acupuncturists, chiropractors and/or other health professionals in his office.

Palevsky wants your child to “breathe more” when they get sick…

And that’s a clue to why we continue to see outbreaks of measles.

This industry of holistic and integrative “health professionals” goes out of their way to make sure parents are too scared to vaccinate their kids.

More on Larry Palevsky

Can You Prove That Jamie McGuire Books Don’t Make Teens Do Drugs?

Apparently, Jamie McGuire is a best-selling author.

According to Yahoo Lifestyle, she is the “author of 20 books in the New Adult genre (for ages 18-30), including Walking Disaster — which debuted at No. 1 on the New York Times, USA Today and Wall Street Journal bestseller lists — as well as the apocalyptic thriller Red Hill.”

And she wants everyone to know that she does not consent!

Can You Prove That Jamie McGuire Books Don’t Make Teens Do Drugs?

What does Jamie McGuire not consent to?

Since her whole post is about proving this and that about vaccines, which she seems to think are bad, I am guessing that she does not consent to getting vaccinated or to vaccinating her kids.

The thing is though, no one is trying to force her to vaccinate her kids.

You can just say that you don’t want to vaccinate your kids, coming out as another anti-vaccine pseudo-celebrity, without hijacking “I do not consent” messaging.

Anyway, her concerns about vaccines have been addressed. Indeed, they have been talked about a million times. If she were truly aware, she would stop being misled by anti-vaccine arguments that scare parents away from thinking that vaccines are safe, with few risks, and necessary.

Do we have proof? We have evidence!

And as the title says, can you prove that her books don’t make teens do drugs?

More on Jame McGuire and Consent

Do Vaccines Cause Mastocytosis?

Children with mastocytosis have extra mast cells, a normal type of cell that we all have that release histamine and other chemicals when activated.

As you can imagine, having too many mast cells, which release too much histamine, isn’t a good thing.

What Causes Mastocytosis?

Mastocytosis, some forms of which have been known since 1869, is caused by spontaneous mutations that aren’t passed on to future generations (somatic mutations).

“Most forms of mastocytosis are caused by a mutation of the KIT gene on the 4q12 chromosome – a mutation that increases cellular reproduction. The c-KIT gene mutation creates an overgrowth of one cell line of mast cells.”

What is mastocytosis?

And the symptoms you have with mastocytosis depends on the type you have, which can include localized (solitary, maculopapular cutaneous, diffuse cutaneous) vs systemic mastocytosis.

“The severity of the symptoms associated with mastocytosis may vary from mild to life-threatening. In general, symptoms occurring in mastocytosis are mainly due to the release of chemicals from the mast cells and thus produce symptoms associated with an allergic reaction.”

Mastocytosis – Rare Disease Database

Localized mastocytosis is usually present at birth or early infancy.

Do Vaccines Cause Mastocytosis?

Since it is caused by spontaneous mutations and is often present at birth or early infancy, there is no reason to think that vaccines could cause mastocytosis.

Vaccines and Mastocytosis

That’s not to say that you shouldn’t think about vaccines if your child has mastocytosis.

Although almost anything can be a trigger for kids with mastocytosis, from insect stings, skin rubbing, antibiotics, aspirin, cough medications, exposure to heat or cold, and stress, there have been a few reports of vaccines being a trigger.

“In childhood, the risk for anaphylactic episodes was limited to children with extensive skin disease, but nonexistent for children with mastocytoma or limited macular lesions. This is in good agreement with the literature, where children with anaphylaxis were described as having clinically severe skin involvement of mastocytosis, although the levels of skin involvement were not given and tryptase concentrations not determined. Children with fatal anaphylaxis, described in three case reports, all had suffered from extensive blistering skin disease…”

Brockow et al on Anaphylaxis in patients with mastocytosis: a study on history, clinical features and risk factors in 120 patients.

It is important to note that these are kids with severe disease though and not the more typical type of localized disease that the average child will have.

An infant with diffuse cutaneous mastocytosis. Lange et al. (CC BY-NC 3.0)
An infant with diffuse cutaneous mastocytosis. Lange et al. (CC BY-NC 3.0)

It should also be noted that viral and bacterial infections with fever, some of which are vaccine preventable, can also be a trigger.

Still, if your child has extensive skin disease, your specialist will likely talk about premedication before vaccines and watching your child closely afterward in case they have an anaphylactic reaction.

Should they get fewer vaccines at a time?

Surprisingly, it depends on who you ask, but it should be noted that all of the discussions about vaccines are for kids with diffuse cutaneous mastocytosis (DCM), a rare form of cutaneous mastocytosis.

“Although patients with mastocytosis can be vaccinated according to the standard schedule, precautions to prevent MC activation and degranulation have been formulated by experts, particularly in cases of diffuse skin manifestations”

And none say to skip vaccines, although some say to use an alternative immunization schedule, getting one vaccine at a time perhaps, especially for the initial doses.

It should be clear that kids with mastocytosis can and should be vaccinated though and vaccines do not actually cause mastocytosis.

More on Vaccines and Mastocytosis

Are You Ready for DNA Vaccines?

Believe it or not, vaccines aren’t a one-size-fits-all kind of a thing.

“There are several different types of vaccines. Each type is designed to teach your immune system how to fight off certain kinds of germs — and the serious diseases they cause.”

Vaccine Types

In addition to live vaccines, like MMR, there are inactivated vaccines, toxoid vaccines, and subunit, recombinant, polysaccharide, and conjugate vaccines.

Are You Ready for DNA Vaccines?

Vaccines made with current technology have helped save millions of lives.

It’s time for some new approaches though, especially as we are seeing the limitations of some of our current vaccines, especially the seasonal flu vaccine.

“DNA vaccines take immunization to a new technological level. These vaccines dispense with both the whole organism and its parts and get right down to the essentials: the microbe’s genetic material. In particular, DNA vaccines use the genes that code for those all-important antigens.”

NIH on Vaccine Types

While a DNA vaccine might sound like something out of the 23rd century, researchers have been studying them since the 1990s.

“Researchers have found that when the genes for a microbe’s antigens are introduced into the body, some cells will take up that DNA. The DNA then instructs those cells to make the antigen molecules. The cells secrete the antigens and display them on their surfaces. In other words, the body’s own cells become vaccine-making factories, creating the antigens necessary to stimulate the immune system.”

NIH on Vaccine Types

Does the idea of being injected with the genes for a microbe’s antigens scare you?

“The original concerns associated with the DNA platform were the potential for genomic integration and development of anti-DNA immune responses. Exhaustive research has found little evidence of integration, and the risk for integration appears to be significantly lower than that associated with naturally occurring mutations”

Ferraro et al on Clinical Applications of DNA Vaccines: Current Progress

What do you think happens when you get the flu?

The flu virus and it’s DNA is taken up by your cells, and those cells then start making more flu proteins.

“This approach offers a number of potential advantages over traditional approaches, including the stimulation of both B- and T-cell responses, improved vaccine stability, the absence of any infectious agent and the relative ease of large-scale manufacture.”

WHO on DNA Vaccines

So where are all of the DNA vaccines?

“However, the results of these early clinical trials were disappointing. The DNA vaccines were safe and well tolerated, but they proved to be poorly immunogenic. The induced antibody titers were very low or nonexistent, CD8+ T-cell responses were sporadic, and CD4+ T-cell responses were of low frequency. However, these studies provided proof of concept that DNA vaccines could safely induce immune responses (albeit low-level responses) in humans.”

Ferraro et al on Clinical Applications of DNA Vaccines: Current Progress

After getting disappointing results in the 1990s, researchers have since moved on to second-generation DNA vaccines, which are being tested for HIV treatment and prevention, Zika, Dengue fever, influenza (DNA vaccine prime), HPV, cancer treatment (metastatic breast, B cell lymphoma, melanoma, prostate, colorectal), chronic hepatitis B treatment, chronic hepatitis C treatment, herpes, and malaria.

There are many completed trials for DNA vaccines.
There are already many completed trials for DNA vaccines.

While many of these DNA vaccines are now in phase I and II trials, unfortunately, that means we are still a long time away from having a DNA vaccine on the immunization schedule.

More on DNA Vaccines